Journal
CELLS
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/cells10123467
Keywords
mesenchyme; lung; development; COPD
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Mesenchymal cells play crucial roles in lung development, regeneration, and diseases, especially in chronic obstructive pulmonary disease.
Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.
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