Journal
CELLS
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/cells11010061
Keywords
nuclear receptors; pregnane X receptor; liver disease; fibrosis; liver cancer; cholestasis; NAFLD; NASH
Categories
Ask authors/readers for more resources
PXR, a nuclear receptor involved in chronic liver diseases, plays a crucial role in liver damage progression, repair, and the neoplastic transition to hepatocellular carcinoma. By modulating the transcription of drug metabolizing enzymes and transporters, PXR is an important factor in chronic liver diseases. PXR and its modulation could be a promising pharmacological target for novel therapeutical approaches to these diseases.
Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different etiologies. Furthermore, PXR activity relates to that of other NRs, such as constitutive androstane receptor (CAR), through a crosstalk that in turn orchestrates a complex network of responses. Thus, besides regulating DMETs, PXR signaling is involved in both liver damage progression and repair and in the neoplastic transition to hepatocellular carcinoma. We here summarize the present knowledge about PXR expression and function in chronic liver diseases characterized by different etiologies and clinical outcome, focusing on the molecular pathways involved in PXR activity. Although many molecular details of these finely tuned networks still need to be fully understood, we conclude that PXR and its modulation could represent a promising pharmacological target for the identification of novel therapeutical approaches to chronic liver diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available