4.6 Review

Deubiquitinases in Neurodegeneration

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

Mila Basic et al.

Summary: The study demonstrates that the deubiquitinase USP11 plays a crucial negative regulatory role in the autophagy pathway, with its absence leading to increased autophagic flux and protection against paralysis induced by amyloid-beta peptide β42 in animals. USP11 impacts the autophagy pathway at multiple sites and inhibiting USP11 can alleviate proteotoxicity symptoms.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25

Qiuyang Zheng et al.

Summary: The study demonstrates a link between Down syndrome and early-onset Alzheimer's disease, with the triplication of chromosome 21 genes exacerbating neuroinflammation. Overexpression of the deubiquitinating enzyme USP25 leads to microglial activation, synaptic deficits, and cognitive impairments, while genetic ablation of Usp25 reduces neuroinflammation and restores synaptic and cognitive function.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

Ai Kaiho-Soma et al.

Summary: The study reveals that the ubiquitin ligase TRIP12 and K29/K48-branched ubiquitin chains play crucial roles in targeted protein degradation, accelerating the degradation process induced by PROTACs. This cooperative mechanism is unique and enhances the efficiency of degrading neo-substrates.

MOLECULAR CELL (2021)

Article Cell Biology

Drosophila USP22/nonstop polarizes the actin cytoskeleton during collective border cell migration

Hammed Badmos et al.

Summary: In Drosophila, the deubiquitinating enzyme nonstop/USP22 plays a crucial role in controlling actin polarization and cell polarity determinant during collective cell migration. This study reveals a novel function of SAGA-independent nonstop/USP22 in cell migration, providing insights for further research in systems where USP22 is required for cell motility and invasion.

JOURNAL OF CELL BIOLOGY (2021)

Article Immunology

USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination

Yana Zhang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration

Amit Sharma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets

Chenming Zeng et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway

Tao Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Cell Biology

Breaking the chains: deubiquitylating enzyme specificity begets function

Michael J. Clague et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells

Svetlana Piatnitskaia et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo

Sandhya Manohar et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Bacterial DUBs: deubiquitination beyond the seven classes

Thomas Hermanns et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Endocrinology & Metabolism

USP8 Deubiquitinates the Leptin Receptor and Is Necessary for Leptin-Mediated Synapse Formation

Tyler Bland et al.

ENDOCRINOLOGY (2019)

Review Biochemistry & Molecular Biology

Ubiquitin signaling and autophagy

Paolo Grumati et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability

Peter Haahr et al.

MOLECULAR CELL (2018)

Article Neurosciences

YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity

Kunikazu Tanji et al.

NEUROBIOLOGY OF DISEASE (2018)

Review Biochemistry & Molecular Biology

Meddling with Fate: The Proteasomal Deubiquitinating Enzymes

Stefanie A. H. de Poot et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Review Neurosciences

Polyglutamine spinocerebellar ataxias - from genes to potential treatments

Henry L. Paulson et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Review Cell Biology

Substrate specificity of the ubiquitin and Ubl proteases

Judith A. Ronau et al.

CELL RESEARCH (2016)

Article Biochemistry & Molecular Biology

The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation

Eniola Funmilayo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

Syed Arif Abdul Rehman et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

Fumiaki Ohtake et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

Omid Tavana et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Frederick C. Nucifora et al.

NATURE COMMUNICATIONS (2016)

Review Oncology

Ubiquitin-specific peptidase 22 functions and its involvement in disease

Johanna Melo-Cardenas et al.

ONCOTARGET (2016)

Article Cell Biology

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

Yuqing Wang et al.

AUTOPHAGY (2015)

Editorial Material Biochemistry & Molecular Biology

Poised for action: USP18 restrains microglial activation in the white matter

Kazuyuki Takata et al.

EMBO JOURNAL (2015)

Article Biochemistry & Molecular Biology

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

Jin-Rui Liang et al.

EMBO REPORTS (2015)

Article Biochemistry & Molecular Biology

The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking

Yuda Huo et al.

JOURNAL OF NEUROCHEMISTRY (2015)

Article Cell Biology

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

Christian N. Cunningham et al.

NATURE CELL BIOLOGY (2015)

Review Neurosciences

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Frances K. Wiseman et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Editorial Material Biochemistry & Molecular Biology

A timer to coordinate substrate processing by the 26S proteasome

Tingting Yao

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Review Pharmacology & Pharmacy

Deubiquitinase inhibition as a cancer therapeutic strategy

Padraig D'Arcy et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Multidisciplinary Sciences

The Parkinson's-associated protein DJ-1 regulates the 20S proteasome

Oren Moscovitz et al.

NATURE COMMUNICATIONS (2015)

Editorial Material Biochemistry & Molecular Biology

A timer to coordinate substrate processing by the 26S proteasome

Tingting Yao

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Cell Biology

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

Marco Gatti et al.

CELL REPORTS (2015)

Article Multidisciplinary Sciences

Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family

Marcell Louis et al.

PLOS ONE (2015)

Review Biochemistry & Molecular Biology

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

Aaron Ciechanover et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2015)

Article Biochemistry & Molecular Biology

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

Matthew Locke et al.

BIOCHEMICAL JOURNAL (2014)

Article Cell Biology

The expanding role for chromatin and transcription in polyglutamine disease

Ryan D. Mohan et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)

Article Multidisciplinary Sciences

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

Baris Bingol et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

Ubiquitination in disease pathogenesis and treatment

Doris Popovic et al.

NATURE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

Evan J. Worden et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Review Cell Biology

Perilous journey: a tour of the ubiquitin-proteasome system

Gary Kleiger et al.

TRENDS IN CELL BIOLOGY (2014)

Review Immunology

Regulation of NF-κB by ubiquitination

Jueqi Chen et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Article Cell Biology

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates

Kaleena M. Bernardi et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Review Neurosciences

AMPARs and Synaptic Plasticity: The Last 25 Years

Richard L. Huganir et al.

NEURON (2013)

Review Physiology

DEUBIQUITYLASES FROM GENES TO ORGANISM

Michael J. Clague et al.

PHYSIOLOGICAL REVIEWS (2013)

Review Oncology

MDM2, MDMX and p53 in oncogenesis and cancer therapy

Mark Wade et al.

NATURE REVIEWS CANCER (2013)

Review Biochemistry & Molecular Biology

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

Koraljka Husnjak et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Review Biochemistry & Molecular Biology

The Ubiquitin Code

David Komander et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Review Biochemistry & Molecular Biology

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

Peter Bai et al.

FEBS LETTERS (2012)

Review Cell Biology

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

Yogesh Kulathu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Ubiquitin-Specific Protease 25 Functions in Endoplasmic Reticulum-Associated Degradation

Jessica R. Blount et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes

Wei-Ling Tsou et al.

PLOS ONE (2012)

Editorial Material Multidisciplinary Sciences

A Unifying Role for Prions in Neurodegenerative Diseases

Stanley B. Prusiner

SCIENCE (2012)

Article Genetics & Heredity

A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling

Junzheng Zhang et al.

G3-GENES GENOMES GENETICS (2012)

Article Biochemistry & Molecular Biology

Roles of HAUSP-mediated p53 regulation in central nervous system development

N. Kon et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Genetics & Heredity

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

S. L. Musone et al.

GENES AND IMMUNITY (2011)

Article Biochemistry & Molecular Biology

Structural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different Stability

Christopher W. Davies et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Review Biochemical Research Methods

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

Min Jae Lee et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Article Biochemistry & Molecular Biology

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

Woong Kim et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes

Kenneth K. Lee et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

Review Neurosciences

Balancing act: deubiquitinating enzymes in the nervous system

Sokol V. Todi et al.

TRENDS IN NEUROSCIENCES (2011)

Article Biochemistry & Molecular Biology

The therapeutic potential of deubiquitinating enzyme inhibitors

Frederic Colland

BIOCHEMICAL SOCIETY TRANSACTIONS (2010)

Review Clinical Neurology

Synapse Pathology in Psychiatric and Neurologic Disease

Myrrhe van Spronsen et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2010)

Article Multidisciplinary Sciences

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

Byung-Hoon Lee et al.

NATURE (2010)

Review Neurosciences

Autophagy gone awry in neurodegenerative diseases

Esther Wong et al.

NATURE NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

Fujun Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

Francisca E. Reyes-Turcu et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Review Biochemistry & Molecular Biology

The emerging complexity of protein ubiquitination

David Komander

BIOCHEMICAL SOCIETY TRANSACTIONS (2009)

Article Biochemistry & Molecular Biology

Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

Saurabh Dayal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Neurosciences

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

Anna E. Cartier et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Clinical Neurology

PROSPECTIVE STUDY OF PERIPHERAL NEUROPATHY IN MACHADO-JOSEPH DISEASE

Marcondes C. Franca et al.

MUSCLE & NERVE (2009)

Article Neurosciences

Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada et al.

NATURE NEUROSCIENCE (2009)

Review Cell Biology

Ubiquitin-binding domains - from structures to functions

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Review Cell Biology

Breaking the chains: structure and function of the deubiquitinases

David Komander et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Medicine, General & Internal

Movement Disorders

Meghan K. Harris et al.

MEDICAL CLINICS OF NORTH AMERICA (2009)

Article Multidisciplinary Sciences

Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

Zhihua Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Genetics & Heredity

The Ataxia (axJ) Mutation Causes Abnormal GABAA Receptor Turnover in Mice

Corinna Lappe-Siefke et al.

PLOS GENETICS (2009)

Article Clinical Neurology

Genomic investigation of α-synuclein multiplication and parkinsonism

Owen A. Ross et al.

ANNALS OF NEUROLOGY (2008)

Article Medicine, General & Internal

A review of Parkinson's disease

C. A. Davie

BRITISH MEDICAL BULLETIN (2008)

Article Cell Biology

Reverse the curse-the role of deubiquitination in cell cycle control

Ling Song et al.

CURRENT OPINION IN CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains

Brett J. Winborn et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

Patricia Chastagner et al.

PLOS ONE (2008)

Article Biochemistry & Molecular Biology

NEDD8:: A new ataxin-3 interactor

Anabela Ferro et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination

Ina Schmitt et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity

Sokol V. Todi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

A ubiquitin ligase complex assembles linear polyubiquitin chains

Takayoshi Kirisako et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation

John Hanna et al.

Article Biochemistry & Molecular Biology

Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor

Jakob Ploug Jorgensen et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Cell Biology

Regulation of monoubiquitinated PCNA by DUB autocleavage

TT Huang et al.

NATURE CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Molecular recognition of p53 and MDM2 by USP7/HAUSP

Y Sheng et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Review Biochemistry & Molecular Biology

A genomic and functional inventory of deubiquitinating enzymes

SMB Nijman et al.

Review Biochemistry & Molecular Biology

Ubiquitylation and cell signaling

K Haglund et al.

EMBO JOURNAL (2005)

Review Endocrinology & Metabolism

Linking the ubiquitin-proteasome pathway to chromatin remodeling/modification by nuclear receptors

HK Kinyamu et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2005)

Article Biochemistry & Molecular Biology

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes

NR Jana et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

A dynamic role of HAUSP in the p53-Mdm2 pathway

MY Li et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

Molecular clearance of ataxin-3 is regulated by a mammalian E4

M Matsumoto et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

Mass spectrometric and mutational analyses reveal lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

H Nishikawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

MKM Chow et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Cell Biology

AMSH is an endosome-associated ubiquitin isopeptidase

J McCullough et al.

JOURNAL OF CELL BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Mechanism and function of deubiquitinating enzymes

AY Amerik et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)

Article Biochemistry & Molecular Biology

The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6

L Martinu et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics

H Scheel et al.

HUMAN MOLECULAR GENETICS (2003)

Review Cell Biology

Deubiquitinating enzymes: Their roles in development, differentiation, and disease

JA Fischer

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 229 (2003)

Article Cell Biology

Spinocerebellar ataxia 7 (SCA7)

AS Lebre et al.

CYTOGENETIC AND GENOME RESEARCH (2003)

Article Neurosciences

USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product

S Hong et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2002)