4.6 Article

Crimean-Congo Hemorrhagic Fever Virus Past Infections Are Associated with Two Innate Immune Response Candidate Genes in Dromedaries

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

MERS-CoV in sheep, goats, and cattle, United Arab Emirates, 2019: Virological and serological investigations reveal an accidental spillover from dromedaries

Pia Weidinger et al.

Summary: The recent COVID-19 pandemic highlights the global threat of emerging zoonotic coronaviruses. MERS-CoV, believed to originate from bats and transmitted through dromedary camels, has been found in multiple countries with a high fatality rate. A study showed that noncamelid livestock like sheep, goats, and cattle do not significantly contribute to the spread of MERS-CoV, with only occasional viral spillover events.

TRANSBOUNDARY AND EMERGING DISEASES (2022)

Article Infectious Diseases

Epidemiological investigation of Crimean-Congo haemorrhagic fever virus infection among the one-humped camels (Camelus dromedarius) in southern Tunisia

Faten Bouaicha et al.

Summary: The survey revealed a high exposure rate of Crimean-Congo haemorrhagic fever virus in one-humped camels from southern Tunisia, primarily transmitted through ticks, although no viral RNA was detected in camel sera.

TICKS AND TICK-BORNE DISEASES (2021)

Article Biotechnology & Applied Microbiology

Identification of a novel lineage of Crimean-Congo haemorrhagic fever virus in dromedary camels, United Arab Emirates

Abdelmalik Khalafalla et al.

Summary: Crimean-Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus that causes a deadly disease known as Crimean-Congo haemorrhagic fever (CCHF) with a high fatality rate. Evidence of CCHFV has been found in dromedary camels in the UAE, with a novel lineage identified in camels and potential reassortment of the genome's M segment.

JOURNAL OF GENERAL VIROLOGY (2021)

Article Multidisciplinary Sciences

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Paul-Albert Koenig et al.

Summary: In this study, new neutralizing nanobodies targeting the SARS-CoV-2 spike protein were developed, showing enhanced neutralizing activity through engineering technology and successfully suppressing the emergence of escape mutants. The findings suggest that nanobodies can neutralize through receptor binding competition and also render virions noninfectious.

SCIENCE (2021)

Review Immunology

Recent Advances in Camel Immunology

Jamal Hussen et al.

Summary: Camels are highly adapted to extreme desert ecosystems and have a strong resistance to pathogens, leading to increased interest in camel immunology. Research focuses on the phenotype and functionality of camel leukocyte subpopulations under different physiological and pathological conditions. Despite progress, gaps remain in understanding camel immune system components such as innate recognition mechanisms and characterization of specific immune cells.

FRONTIERS IN IMMUNOLOGY (2021)

Article Infectious Diseases

Crimean-Congo hemorrhagic fever virus antibody prevalence in Mauritanian livestock (cattle, goats, sheep and camels) is stratified by the animal's age

Ansgar Schulz et al.

Summary: The study investigated CCHFV seroprevalence in different species in Mauritania and found that cattle and camels had higher infection rates compared to goats and sheep, with infection rates increasing with age.

PLOS NEGLECTED TROPICAL DISEASES (2021)

Article Cell Biology

Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries

Sara Lado et al.

Summary: Testing immune-response genes in dromedaries from the UAE identified candidate genes associated with MERS-CoV infection that play important roles in adaptive and innate immune responses, as well as ciliary movement in the respiratory tract. These results suggest similar host genetic pathways associated with betacoronaviruses, but further research is needed to understand MERS-CoV dynamics in dromedaries and humans.

CELLS (2021)

Review Microbiology

Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe

Nariman Shahhosseini et al.

Summary: The global spread of ticks and various tick-borne viruses (TBVs) indicates the emergence of potential new tick-borne diseases. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging tick-borne virus in the Nairoviridae family that can cause severe and fatal diseases in humans.

MICROORGANISMS (2021)

Article Immunology

Association of Dromedary Camels and Camel Ticks with Reassortant Crimean-Congo Hemorrhagic Fever Virus, United Arab Emirates

Jeremy Camp et al.

Summary: A potentially novel reassortant of Crimean-Congo hemorrhagic fever virus was detected in camels at the largest livestock market in the United Arab Emirates, with zoonotic transmission associated with dromedaries and camel ticks. Seroprevalence in cattle, sheep, and goats is minimal.

EMERGING INFECTIOUS DISEASES (2021)

Review Oncology

The Therapeutic Potential of Nanobodies

Ivana Jovcevska et al.

BIODRUGS (2020)

Article Multidisciplinary Sciences

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Leo Hanke et al.

NATURE COMMUNICATIONS (2020)

Review Infectious Diseases

Towards a Sustainable One Health Approach to Crimean-Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge

Teresa E. Sorvillo et al.

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2020)

Letter Immunology

Crimean-Congo Hemorrhagic Fever Virus Endemicity in United Arab Emirates, 2019

Jeremy V. Camp et al.

EMERGING INFECTIOUS DISEASES (2020)

Review Biodiversity Conservation

A Review of Zoonotic Pathogens of Dromedary Camels

Sophie Zhu et al.

ECOHEALTH (2019)

Article Biochemistry & Molecular Biology

Improving Illumina assemblies with Hi-C and long reads: An example with the North African dromedary

Jean P. Elbers et al.

MOLECULAR ECOLOGY RESOURCES (2019)

Review Genetics & Heredity

The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics

Salvatrice Ciccarese et al.

FRONTIERS IN GENETICS (2019)

Review Immunology

Stories From the Dendritic Cell Guardhouse

J. Kenneth Hoober et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

C-type lectins in immunity and homeostasis

Gordon D. Brown et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Public, Environmental & Occupational Health

Human-Dromedary Camel Interactions and the Risk of Acquiring Zoonotic Middle East Respiratory Syndrome Coronavirus Infection

C. Gossner et al.

ZOONOSES AND PUBLIC HEALTH (2016)

Review Immunology

Pathogen-host-environment interplay and disease emergence

Anneke Engering et al.

EMERGING MICROBES & INFECTIONS (2013)

Article Agriculture, Dairy & Animal Science

Epidemic characterization and modeling within herd transmission dynamics of an emerging trans-boundary camel disease epidemic in Ethiopia

Bekele Megersa et al.

TROPICAL ANIMAL HEALTH AND PRODUCTION (2012)

Article Virology

Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries

Onder Ergonul

CURRENT OPINION IN VIROLOGY (2012)

Article Biotechnology & Applied Microbiology

ggbio: an R package for extending the grammar of graphics for genomic data

Tengfei Yin et al.

GENOME BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Major Histocompatibility Complex (MHC) Markers in Conservation Biology

Beata Ujvari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Genetics & Heredity

PLINK: A tool set for whole-genome association and population-based linkage analyses

Shaun Purcell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Article Biodiversity Conservation

Beyond Bonferroni: Less conservative analyses for conservation genetics

Shawn R. Narum

CONSERVATION GENETICS (2006)

Article Virology

Crimean-Congo hemorrhagic fever virus genomics and global diversity

Varough M. Deyde et al.

JOURNAL OF VIROLOGY (2006)

Article Biology

Major histocompatibility complex diversity influences parasite resistance and innate immunity in sticklebacks

J Kurtz et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2004)

Review Pharmacology & Pharmacy

Crimean-Congo hemorrhagic fever

CA Whitehouse

ANTIVIRAL RESEARCH (2004)