4.6 Article

Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4+ and CD8+ T Cells

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Well-Defined Mannosylated Polymer for Peptide Vaccine Delivery with Enhanced Antitumor Immunity

Shixian Lv et al.

Summary: The development of a mannosylated polymer for anticancer peptide antigen delivery through self-assembly into micelles has improved the stability and cellular uptake of peptide antigens, resulting in enhanced immune responses against cancer.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Engineering, Biomedical

Drug-eluting immune checkpoint blockade antibody-nanoparticle conjugate enhances locoregional and systemic combination cancer immunotherapy through T lymphocyte targeting

David M. Francis et al.

Summary: The development of an antibody-nanoparticle conjugate platform has shown promising results in enhancing the delivery of small molecule therapeutics to T lymphocytes, improving both local and systemic anti-tumor effects in cancer immunotherapy.

BIOMATERIALS (2021)

Article Immunology

Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance

Chitavi D. Maulloo et al.

Summary: Inverse vaccines that target antigens to antigen-presenting cells have the potential to induce immune tolerance and prevent immune responses to allergens and autoimmunity. This study shows that synthetic glycosylation can effectively target antigens to hepatic and lymph node antigen-presenting cells, leading to local and systemic tolerogenic responses. Additionally, presentation of antigen released from the glycoconjugate is mainly mediated by lymph node-resident dendritic cells, highlighting the importance of targeting antigen to specific cellular components for inducing tolerance.

FRONTIERS IN IMMUNOLOGY (2021)

Article Gastroenterology & Hepatology

TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study

Ciaran P. Kelly et al.

Summary: TAK-101, a gluten protein encapsulated in nanoparticles, demonstrated promising results in reducing gluten-induced immune activation in patients with CeD, suggesting a novel approach for other immune-mediated diseases.

GASTROENTEROLOGY (2021)

Review Endocrinology & Metabolism

Novel delivery mechanisms for antigen-specific immunotherapy

Tobias Neef et al.

Summary: Novel ways of delivering antigens, including particle and nonparticle approaches, have been explored for antigen-specific immunotherapy (ASI). One main focus has been on targeting antigen-presenting cells in a tolerogenic context, which has shown potential in inducing regulatory T cells effective against complex immune responses. While the use of novel delivery approaches for ASI in general clinical settings for autoimmune diseases is still uncertain, promising results have been seen in preclinical studies and early clinical trials.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2021)

Review Immunology

Regulatory T Cells and Human Disease

Shimon Sakaguchi et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Article Gastroenterology & Hepatology

Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease

Tobias L. Freitag et al.

GASTROENTEROLOGY (2020)

Article Medicine, General & Internal

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

Kevan C. Herold et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biotechnology & Applied Microbiology

Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates

Ryan M. Pearson et al.

MOLECULAR THERAPY (2017)

Article Nanoscience & Nanotechnology

An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy

Derrick P. McCarthy et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Review Endocrinology & Metabolism

Tolerogenic Nanoparticles to Treat Islet Autoimmunity

Tobias Neef et al.

CURRENT DIABETES REPORTS (2017)

Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot et al.

JOURNAL OF IMMUNOLOGY (2017)

Article Engineering, Biomedical

Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation

Kelan A. Hlavaty et al.

BIOMATERIALS (2016)

Article Multidisciplinary Sciences

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization

Charles B. Smarr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

CD8+CD122+ T-cells: a newly emerging regulator with central memory cell phenotypes

Junfeng Liu et al.

FRONTIERS IN IMMUNOLOGY (2015)

Article Cell Biology

CD8+ CD122+ PD-1- effector cells promote the development of diabetes in NOD mice

Boerge Arndt et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2015)

Article Multidisciplinary Sciences

CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

Hye-Jung Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Immunology

Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF

Vitaly Ablamunits et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

Article Allergy

Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease

AJ Morgan et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2005)

Article Immunology

Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis

M Rifa'i et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2003)

Article Multidisciplinary Sciences

Control of regulatory T cell development by the transcription factor Foxp3

S Hori et al.

SCIENCE (2003)