4.6 Article

The Bilateral Interplay between Cancer Immunotherapies and Neutrophils' Phenotypes and Sub-Populations

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

Chang Cui et al.

Summary: Human neutrophils release ELANE, which can selectively kill a variety of cancer cells, potentially serving as a broad anti-cancer therapy. ELANE liberates the CD95 death domain through a specific mechanism to selectively eradicate cancer cells without significant toxicity to non-cancer cells.
Article Oncology

Tumor-Derived Factors Differentially Affect the Recruitment and Plasticity of Neutrophils

Ludovica Arpinati et al.

Summary: Neutrophils, an abundant type of circulating leukocytes, play crucial roles in cancer biology. This study reveals that tumor-associated neutrophils can originate from different subpopulations and exhibit plasticity under the influence of chemokines and tumor-derived factors, potentially transitioning through phenotypical changes.

CANCERS (2021)

Article Oncology

Tumor-Associated Neutrophils Drive B-cell Recruitment and Their Differentiation to Plasma Cells

Merav E. Shaul et al.

Summary: The study suggests that tumor-associated neutrophils play a crucial role in recruiting and modulating B cells into plasma cells in the tumor microenvironment, thereby opening new avenues in cancer immunotherapy targeting strategies.

CANCER IMMUNOLOGY RESEARCH (2021)

Review Pharmacology & Pharmacy

PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy

Jinhua Liu et al.

Summary: Programmed death protein 1 (PD1) is an important immune checkpoint on T cells that plays a crucial role in downregulating the immune system and promoting self-tolerance, while its ligand, programmed cell death ligand 1 (PDL1), is overexpressed in malignant tumor cells, contributing to immune evasion and treatment failure. Despite the clinical efficacy of PD1/PDL1 inhibitors in many tumors, some patients may develop drug resistance, highlighting the need for further research into improving targeted therapies and understanding the associated safety issues.

FRONTIERS IN PHARMACOLOGY (2021)

Article Cell Biology

The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity in Cancer

Olga Yajuk et al.

Summary: The PD-L1/PD-1 axis plays a crucial role in mediating immune tolerance and promoting tumor growth by inhibiting anti-tumor immunity. Blocking this axis has been shown to help maintain the anti-tumor functions of the adaptive immune system. Neutrophils consist of distinct subpopulations with either pro- or anti-tumor properties, and PD-L1 expression in neutrophils can either promote or inhibit tumor growth.

CELLS (2021)

Article Medicine, General & Internal

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC

Roy S. Herbst et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Oncology

Tumor-Associated Neutrophils in Cancer: Going Pro

Lingyun Wu et al.

CANCERS (2019)

Review Oncology

Tumour-associated neutrophils in patients with cancer

Merav E. Shaul et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Review Cell Biology

The neutrophil: one cell on many missions or many cells with different agendas?

Gustaf Christoffersson et al.

CELL AND TISSUE RESEARCH (2018)

Review Medicine, General & Internal

Neutrophil phenotypes in health and disease

Pien Hellebrekers et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

Neutrophil elastase in the tumor microenvironment

Irina Lerman et al.

STEROIDS (2018)

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1/PD-L1 Blockade

Michele Moschetta et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Oncology

Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer

Xiaoming Liu et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2017)

Article Oncology

Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

Lisa Andzinski et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Review Oncology

PD-1/PD-L1 blockade in cancer treatment: perspectives and issues

Junzo Hamanishi et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2016)

Review Nutrition & Dietetics

Neutrophil myeloperoxidase and its substrates: formation of specific markers and reactive compounds during inflammation

Yoji Kato

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2016)

Article Medicine, General & Internal

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Martin Reck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

Neutrophils in cancer: neutral no more

Seth B. Coffelt et al.

NATURE REVIEWS CANCER (2016)

Review Cell Biology

Distinct Functions of Neutrophil in Cancer and Its Regulation

Zvi Granot et al.

MEDIATORS OF INFLAMMATION (2015)

Article Biochemistry & Molecular Biology

The prognostic landscape of genes and infiltrating immune cells across human cancers

Andrew J. Gentles et al.

NATURE MEDICINE (2015)

Review Immunology

Neutrophils in Cancer: Two Sides of the Same Coin

Eileen Uribe-Querol et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

Article Oncology

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

Inbal Mishalian et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

Review Immunology

Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

NATURE REVIEWS IMMUNOLOGY (2013)