Journal
CELLS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cells11040741
Keywords
hepatitis B virus; HBx protein; hepatocellular carcinoma; cancer hallmarks; therapeutics
Categories
Ask authors/readers for more resources
This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC, and emphasizes the potential of targeting HBx for novel combinatorial therapies against liver cancer.
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
