4.6 Article

Circulating miR-499a and miR-125b as Potential Predictors of Left Ventricular Ejection Fraction Improvement after Cardiac Resynchronization Therapy

Journal

CELLS
Volume 11, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/cells11020271

Keywords

heart failure; adverse remodelling; cardiac resynchronization therapy; microRNAs; cardiac biomarker; cardiac therapeutic target

Categories

Funding

  1. Spanish Society of Cardiology (PROYECTOS DE INVESTIGACION SEC-ROVI para la investigacion en insuficiencia cardiaca de la Seccion de Insuficiencia Cardiaca de la SEC)
  2. Xunta de Galicia: Programa de Consolidacion de Unidades de Investigacion Competitivas do SUG [GPC 2016/022, GRC 2019/02]
  3. European Union European Regional Development Fund (ERDF)
  4. Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares (CIBERCV)
  5. Centro Singular de Investigacion de Galicia acreditacion [ED431G 2019/02]

Ask authors/readers for more resources

The differences in circulating miRNA may contribute to prognostic stratification of patients undergoing cardiac resynchronization therapy, and the preimplant cardiac context and remodeling response are key factors for therapeutic success.
Cardiac resynchronization therapy represents a therapeutic option for heart failure drug-refractory patients. However, due to the lack of success in 30% of the cases, there is a demand for an in-depth analysis of individual heterogeneity. In this study, we aimed to evaluate the prognostic value of circulating miRNA differences. Responder patients were defined by a composite endpoint of the presence of left ventricular reverse remodelling (a reduction >= 15% in telesystolic volume and an increment >= 10% in left ventricular ejection fraction). Circulating miRNAs signature was analysed at the time of the procedure and at a 6-month follow-up. An expression analysis showed, both at baseline and at follow-up, differences between responders and non-responders. Responders presented lower baseline expressions of miR-499, and at follow-up, downregulation of miR-125b-5p, both associated with a significant improvement in left ventricular ejection fraction. The miRNA profile differences showed a marked sensitivity to distinguish between responders and non-responders. Our data suggest that miRNA differences might contribute to prognostic stratification of patients undergoing cardiac resynchronization therapy and suggest that preimplant cardiac context as well as remodelling response are key to therapeutic success.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available