Journal
CELLS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cells10112887
Keywords
osteoarthritis; extracellular vesicles; mesenchymal stem cells; chondrocytes; inflammation; bone homeostasis
Categories
Ask authors/readers for more resources
Osteoarthritis is a common degenerative disease that can lead to persistent pain and motion restriction, and stem cells, particularly mesenchymal stem cells, have been explored as a potential alternative therapy. Extracellular vesicles containing trophic factors are crucial in MSC-based treatment, and can target various biological processes associated with cartilage degradation. However, outcomes of EV treatment for OA can vary depending on the EV cargo, cell source, and pathological condition.
Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has been shown that trophic factors enveloped in extracellular vesicles (EVs), including exosomes, are a crucial aspect of MSC-based treatment for OA. Evidently, EVs derived from different MSC sources might rescue the OA phenotype by targeting many biological processes associated with cartilage extracellular matrix (ECM) degradation and exerting protective effects on different joint cell types. Despite this advancement, different studies employing EV treatment for OA have revealed reverse outcomes depending on the EV cargo, cell source, and pathological condition. Hence, in this review, we aim to summarize and discuss the possible effects of MSC-derived EVs based on recent findings at different stages of OA development, including effects on cartilage ECM, chondrocyte biology, osteocytes and bone homeostasis, inflammation, and pain management. Additionally, we discuss further strategies and technical advances for manipulating EVs to specifically target OA to bring the therapy closer to clinical use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available