4.6 Article

Neutrophil Extracellular Traps Contribute to COVID-19 Hyperinflammation and Humoral Autoimmunity

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

Yun Young Lee et al.

Summary: SARS-CoV-2 infection can lead to cytokine storm and multi-organ failure, but exogenously administered long-acting DNase-1 can effectively reduce cfDNA levels and neutrophil activities, potentially serving as a therapeutic intervention for life-threatening SARS-CoV-2-mediated illnesses.

BIOMATERIALS (2021)

Article Biochemistry & Molecular Biology

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei et al.

Summary: Identification of essential host genes for SARS-CoV-2 infection, including ACE2 and Cathepsin L, and the discovery of pro-viral genes and pathways specific to SARS lineage and pan-coronavirus provide potential therapeutic targets and insights into pathogenesis of COVID-19. Small-molecule antagonists of these gene products inhibited SARS-CoV-2 infection across species, highlighting their conserved role in susceptibility to highly pathogenic CoVs.
Article Medicine, Research & Experimental

COVID-19 and Immunological Dysregulation: Can Autoantibodies be Useful?

Simona Pascolini et al.

Summary: Auto-antibodies are frequently detected in patients with COVID-19, potentially indicating a role in immune dysregulation and a link to poor prognosis.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

Review Rheumatology

COVID-19 and Autoimmune Diseases: A Systematic Review of Reported Cases

Mariam Ahmed Saad et al.

Summary: A review of COVID-19 cases with associated autoimmune manifestations found 33 cases out of 20 studies, ranging from a 6-month-old infant to an 89-year-old female. The time between viral illness symptoms and onset of autoimmune symptoms ranged from 2 to 33 days, with a variety of autoimmune diseases reported, including Guillain-Barre syndrome, autoimmune hemolytic anemia, and others. This highlights a potential association between COVID-19 and the development of autoimmune diseases.

CURRENT RHEUMATOLOGY REVIEWS (2021)

Review Medicine, General & Internal

Postinfectious Epigenetic Immune Modifications - A Double-Edged Sword

Andrew R. DiNardo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Immunology

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

Fanny Onodi et al.

Summary: Studies have shown that human pDCs can be efficiently activated by SARS-CoV-2 particles and may contribute to type I IFN-dependent immunity against SARS-CoV-2 infection.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Immunology

Proinflammatory IgG Fc structures in patients with severe COVID-19

Saborni Chakraborty et al.

Summary: COVID-19 is often characterized by a hyperinflammatory syndrome, and disease severity is associated with specific antibody structures that enhance inflammatory responses.

NATURE IMMUNOLOGY (2021)

Article Endocrinology & Metabolism

Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes

Emmanouil Korakas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Article Medicine, Research & Experimental

Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19

Yaqing Zhou et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

Ulf Andersson et al.

MOLECULAR MEDICINE (2020)

Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

Letter Rheumatology

Autoantibodies related to systemic autoimmune rheumatic diseases in severely ill patients with COVID-19

Panayiotis G. Vlachoyiannopoulos et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

Article Immunology

Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse

Luiz G. Gardinassi et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Immune Response, Inflammation, and the Clinical Spectrum of COVID-19

Luis F. Garcia

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, General & Internal

Vascular occlusion by neutrophil extracellular traps in COVID-19

Moritz Leppkes et al.

EBIOMEDICINE (2020)

Article Immunology

Autoinflammatory and autoimmune conditions at the crossroad of COVID-19

Yhojan Rodriguez et al.

JOURNAL OF AUTOIMMUNITY (2020)

Article Medicine, Research & Experimental

Neutrophil extracelluar traps in COVID-19

Yu Zuo et al.

JCI INSIGHT (2020)

Article Multidisciplinary Sciences

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Julien Carvelli et al.

NATURE (2020)

Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Immunology

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Flavio Protasio Veras et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Immunology

A Granulocytic Signature Identifies COVID-19 and Its Severity

Joana Vitte et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Editorial Material Medicine, General & Internal

Trained Innate Immunity, Epigenetics, and Covid-19

Alberto Mantovani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

Article Immunology

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Elizabeth R. Mann et al.

SCIENCE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis

Liam J. O'Neil et al.

SCIENCE ADVANCES (2020)

Article Infectious Diseases

Preliminary report of in vitro and in vivo effectiveness of dornase alfa on SARS-CoV-2 infection

H. K. Okur et al.

NEW MICROBES AND NEW INFECTIONS (2020)

Review Urology & Nephrology

Extracellular DNA traps in inflammation, injury and healing

Christoph Daniel et al.

NATURE REVIEWS NEPHROLOGY (2019)

Article Multidisciplinary Sciences

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

Pragnesh Mistry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Microbiology

ISG15 in antiviral immunity and beyond

Yi-Chieh Perng et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

Review Immunology

Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE

Aparna Mahajan et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

Silke M. Currie et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death

Christian Beyer et al.

INNATE IMMUNITY (2012)

Review Immunology

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

Mariana J. Kaplan et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

Yvonne Lai et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

Abdul Hakkim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)