Journal
CELLS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cells10112840
Keywords
biological memory; fibroblasts; wound healing; fibrosis; cancer; inflammation; metabolism; positional identity; epigenetic modification; mechanical stress; cell fate
Categories
Funding
- Barts Charity [MGU0573]
- Medical College of Saint Bartholomews Hospital Trust
- William Harvey Research Institute, Queen Mary University of London
- EMBO Advanced Fellowship [aALTF523-2017]
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Fibroblasts, as the major cell population in connective tissue of organs, play a key role in remodeling the extracellular matrix, but are also recognized as a highly diverse cell population that constantly responds and adapts to their environment.
Fibroblasts are the major cell population in the connective tissue of most organs, where they are essential for their structural integrity. They are best known for their role in remodelling the extracellular matrix, however more recently they have been recognised as a functionally highly diverse cell population that constantly responds and adapts to their environment. Biological memory is the process of a sustained altered cellular state and functions in response to a transient or persistent environmental stimulus. While it is well established that fibroblasts retain a memory of their anatomical location, how other environmental stimuli influence fibroblast behaviour and function is less clear. The ability of fibroblasts to respond and memorise different environmental stimuli is essential for tissue development and homeostasis and may become dysregulated in chronic disease conditions such as fibrosis and cancer. Here we summarise the four emerging key areas of fibroblast adaptation: positional, mechanical, inflammatory, and metabolic memory and highlight the underlying mechanisms and their implications in tissue homeostasis and disease.
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