Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF (vol 10, 38, 2021)

Summary: The study revealed that NPTX2 cerebrospinal fluid levels were reduced in patients with Dementia with Lewy bodies (DLB) and were closely correlated with decreased VGF and alpha-synuclein cerebrospinal fluid levels. The combination of these protein markers had high differentiating power between DLB and cognitively healthy subjects, while NPTX2 levels were related to decreased functioning in the visual spatial domain.