4.6 Review

The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma

Related references

Note: Only part of the references are listed.
Article Cell Biology

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

Sonia Brun et al.

Summary: The new autophagy inhibitor GNS561 shows high liver tropism and potent antitumor activity, particularly against hepatocellular carcinoma. Its mechanism of action involves lysosomal disruption and induction of cell death in tumor cells.

AUTOPHAGY (2022)

Review Oncology

The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma

Soudeh Ghafouri-Fard et al.

Summary: The dysregulation of long non-coding RNAs (lncRNAs) is associated with the pathogenesis of hepatocellular carcinoma (HCC), impacting the expression of tumor suppressor genes and oncogenes, altering cancer-related signaling pathways. The interaction between lncRNAs and miRNAs plays a crucial role in the development of HCC.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects

Xinrong Lin et al.

Summary: Long non-coding RNAs exhibit remarkable aberrant expression in hepatocellular carcinoma, influencing multiple biological processes in tumor cells, including proliferation, invasion, migration, metastasis, apoptosis, and therapy resistance. They have been recognized as crucial targets in clinical target therapy to halt the growth of liver cancer and extend the lifespan of patients with hepatocellular carcinoma.

FRONTIERS IN ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

Paulina Hennig et al.

Summary: P62 is a highly conserved adaptor protein involved in important cellular processes, regulating tissue homeostasis, inflammation, and diseases like cancer. Through interactions with multiple partners, P62 influences key pathways and acts as a central signaling hub for pro- and anti-inflammatory pathways. Its roles in autophagy, inflammation, and cancer highlight its potential as a target for therapeutic strategies in disease progression.

BIOMEDICINES (2021)

Review Gastroenterology & Hepatology

Recent advances in the surgical management of hepatocellular carcinoma

Georgios K. Glantzounis et al.

Summary: The incidence of hepatocellular carcinoma is on the rise due to metabolic syndrome and nonalcoholic fatty liver disease. Liver resection and transplantation are main treatment options, offering long-term survival and potential cure. Individualized treatment plans are recommended, with cases discussed in multidisciplinary tumor boards for maximum benefit.

ANNALS OF GASTROENTEROLOGY (2021)

Article Food Science & Technology

Role of autophagy in alcohol and drug-induced liver injury

Jessica A. Williams et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Gastroenterology & Hepatology

Autophagy and liver cancer

Xiaojuan Chao et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2020)

Review Biology

The physiological roles of autophagy in the mammalian life cycle

Liang Wang et al.

BIOLOGICAL REVIEWS (2019)

Review Gastroenterology & Hepatology

Autophagy in liver diseases: Time for translation?

Manon Allaire et al.

JOURNAL OF HEPATOLOGY (2019)

Review Endocrinology & Metabolism

Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

Ivan E. Alfaro et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Pharmacology & Pharmacy

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

Helmut Denk et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Philipp Kirchner et al.

PLOS BIOLOGY (2019)

Review Cell Biology

The Lysosome Signaling Platform: Adapting With the Times

Subothan Inpanathan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Cell Biology

Chaperone-Mediated Autophagy in the Liver: Good or Bad?

Srikanta Dash et al.

CELLS (2019)

Article Gastroenterology & Hepatology

AASLD guidelines for the treatment of hepatocellular carcinoma

Julie K. Heimbach et al.

HEPATOLOGY (2018)

Review Biochemistry & Molecular Biology

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

Kumsal Tekirdag et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Cell Biology

Mechanisms and context underlying the role of autophagy in cancer metastasis

Christopher M. Dower et al.

AUTOPHAGY (2018)

Review Cell Biology

The coming of age of chaperone-mediated autophagy

Susmita Kaushik et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Cell Biology

Mechanism and medical implications of mammalian autophagy

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Pharmacology & Pharmacy

Long noncoding RNAs act as regulators of autophagy in cancer

Ting Sun

PHARMACOLOGICAL RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Role of Beclin 1 expression in patients with hepatocellular carcinoma: a meta-analysis

Chaojie Liang et al.

ONCOTARGETS AND THERAPY (2018)

Review Gastroenterology & Hepatology

Homeostatic Role of Autophagy in Hepatocytes

Bilon Khambu et al.

SEMINARS IN LIVER DISEASE (2018)

Review Gastroenterology & Hepatology

Autophagy and liver cancer

Yunus Akkoc et al.

TURKISH JOURNAL OF GASTROENTEROLOGY (2018)

Review Immunology

NF-κB, inflammation, immunity and cancer: coming of age

Koji Taniguchi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Molecular definitions of autophagy and related processes

Lorenzo Galluzzi et al.

EMBO JOURNAL (2017)

Review Oncology

Hepatocellular carcinoma (HCC): beyond sorafenib-chemotherapy

Dae Won Kim et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2017)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Oncology

Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma

Zhen-Bin Ding et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

Article Pharmacology & Pharmacy

A cell-based quantitative high-throughput image screening identified novel autophagy modulators

Yuan Li et al.

PHARMACOLOGICAL RESEARCH (2016)

Review Biochemistry & Molecular Biology

The Dual Roles of NRF2 in Cancer

Silvia Menegon et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Article Pharmacology & Pharmacy

Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease

Rebecca A. Barnard et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

Review Biochemistry & Molecular Biology

The receptor proteins: pivotal roles in selective autophagy

Zhijie Xu et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)

Article Biochemistry & Molecular Biology

p62 links autophagy and Nrf2 signaling

Tao Jiang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Review Immunology

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

Eric I. Elliott et al.

IMMUNOLOGICAL REVIEWS (2015)

Review Biochemistry & Molecular Biology

The Role of Autophagy in Hepatocellular Carcinoma

Yoo Jin Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Biochemistry & Molecular Biology

An Overview of Autophagy: Morphology, Mechanism, and Regulation

Katherine R. Parzych et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Biochemistry & Molecular Biology

Regulation Where Autophagy Intersects the Inflammasome

Mary A. Rodgers et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Editorial Material Cell Biology

When cytoprotective autophagy isn't. and even when it is

David A. Gewirtz

AUTOPHAGY (2014)

Review Cell Biology

Chaperone-mediated autophagy: roles in disease and aging

Ana Maria Cuervo et al.

CELL RESEARCH (2014)

Article Pathology

Impaired autophagy response in human hepatocellular carcinoma

Lili Bao et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2014)

Review Gastroenterology & Hepatology

Liver autophagy: much more than just taking out the trash

Jaime L. Schneider et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

Review Oncology

Mechanisms of disseminated cancer cell dormancy: an awakening field

Maria Soledad Sosa et al.

NATURE REVIEWS CANCER (2014)

Article Multidisciplinary Sciences

Promoting Colonization in Metastatic HCC Cells by Modulation of Autophagy

Yuan-Fei Peng et al.

PLOS ONE (2013)

Review Biochemistry & Molecular Biology

The Intriguing Life of Autophagosomes

Dalibor Mijaljica et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Review Biochemistry & Molecular Biology

Biogenesis and Cargo Selectivity of Autophagosomes

Hilla Weidberg et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)

Editorial Material Biology

Following autophagy step by step

Tom Egil Hansen et al.

BMC BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

Review Cell Biology

Autophagy in the Cellular Energetic Balance

Rajat Singh et al.

CELL METABOLISM (2011)

Article Pharmacology & Pharmacy

The dual role of autophagy in cancer

Eeva-Liisa Eskelinen

CURRENT OPINION IN PHARMACOLOGY (2011)

Review Veterinary Sciences

Pathophysiological Role of Autophagy: Lesson from Autophagy-Deficient Mouse Models

Yoshinobu Ichimura et al.

EXPERIMENTAL ANIMALS (2011)

Article Cell Biology

Autophagy-deficient mice develop multiple liver tumors

Akito Takamura et al.

GENES & DEVELOPMENT (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Article Pathology

Mutational and expressional analyses of ATG5, an autophagy-related gene, in gastrointestinal cancers

Chang Hyeok An et al.

PATHOLOGY RESEARCH AND PRACTICE (2011)

Review Multidisciplinary Sciences

A Perspective on Cancer Cell Metastasis

Christine L. Chaffer et al.

SCIENCE (2011)

Article Cell Biology

Chaperone-Mediated Autophagy Is Required for Tumor Growth

Maria Kon et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Review Biochemistry & Molecular Biology

Autophagy is a therapeutic target in anticancer drug resistance

Suning Chen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)

Article Cell Biology

Autophagy and metastasis: another double-edged sword

Candia M. Kenific et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Cell Biology

Role of autophagy in suppression of inflammation and cancer

Eileen White et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Autophagy and tumorigenesis

Nan Chen et al.

FEBS LETTERS (2010)

Review Gastroenterology & Hepatology

Autophagy in liver diseases

Pierre-Emmanuel Rautou et al.

JOURNAL OF HEPATOLOGY (2010)

Review Oncology

Autophagy: cellular and molecular mechanisms

Danielle Glick et al.

JOURNAL OF PATHOLOGY (2010)

Article Biochemistry & Molecular Biology

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

Jiayi Wang et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemistry & Molecular Biology

ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ian G. Ganley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Gregory Bellot et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

J-P Pursiheimo et al.

ONCOGENE (2009)

Article Cell Biology

Beclin 1 bridges autophagy, apoptosis and differentiation

Jianrong Wang

AUTOPHAGY (2008)

Review Gastroenterology & Hepatology

Cellular and molecular mechanisms of liver injury

Harmeet Malhi et al.

GASTROENTEROLOGY (2008)

Article Medicine, Research & Experimental

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

Zhen Lu et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Cell Biology

Induction of autophagy during extracellular matrix detachment promotes cell survival

Christopher Fung et al.

MOLECULAR BIOLOGY OF THE CELL (2008)

Article Biochemistry & Molecular Biology

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Serhiy Pankiv et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Autophagy: molecular machinery for self-eating

T Yorimitsu et al.

CELL DEATH AND DIFFERENTIATION (2005)

Article Cell Biology

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

M Komatsu et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

JJ Lum et al.

Review Biochemistry & Molecular Biology

Pathophysiology of chaperone-mediated autophagy

A Massey et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

ZY Yue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)