Journal
CANCERS
Volume 13, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/cancers13194866
Keywords
Expanded Prostate Cancer Index Composite (EPIC); image-guided radiation therapy; magnetic resonance-guided radiotherapy (MRgRT); patient-reported outcome measures (PROMs); prostate cancer; questionnaire; stereotactic body radiotherapy (SBRT); toxicity
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Funding
- Chau Hoi Shuen Foundation
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The study found that 1.5T MRgSBRT treatment for localized PC had low toxicity, supporting its clinical use.
Background: Magnetic resonance-guided stereotactic body radiotherapy (MRgSBRT) offers the potential for achieving better prostate cancer (PC) treatment outcomes. This study reports the preliminary clinical results of 1.5T MRgSBRT in localized PC, based on both clinician-reported outcome measurement (CROM) and patient-reported outcome measurement (PROM). Methods: Fifty-one consecutive localized PC patients were prospectively enrolled with a median follow-up of 199 days. MRgSBRT was delivered in five fractions of 7.25-8 Gy with daily online adaptation. Clinician-reported gastrointestinal (GI) and genitourinary (GU) adverse events based on the Common Terminology Criteria for Adverse Events (CTCAE) Scale v. 5.0 were assessed. The Expanded Prostate Cancer Index Composite Questionnaire was collected at baseline, 1 month, and every 3 months thereafter. Serial prostate-specific antigen measurements were longitudinally recorded. Results: The maximum cumulative clinician-reported grade & GE; 2 acute GU and GI toxicities were 11.8% (6/51) and 2.0% (1/51), respectively, while grade & GE; 2 subacute GU and GI toxicities were 2.3% (1/43) each. Patient-reported urinary, bowel, and hormonal domain summary scores were reduced at 1 month, then gradually returned to baseline levels, with the exception of the sexual domain. Domain-specific subscale scores showed similar longitudinal changes. All patients had early post-MRgSBRT biochemical responses. Conclusions: The finding of low toxicity supports the accumulation of clinical evidence for 1.5T MRgSBRT in localized PC.
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