Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
Volume 27, Issue 1, Pages 52-67Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09603123.2016.1268677
Keywords
Prenatal exposure; maternal smoking; mitochondrial DNA content; MT-CO1; MT-CO2; molecular biomarkers in cord serum; gestational age
Funding
- National Cancer Institute [NCI 5U01CA13, NCI K01CA164092]
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We investigated if prenatal exposures to tobacco smoke lead to changes in mitochondrial DNA content (mtDNA) in cord serum and adversely affect newborns' health. Umbilical cord serum cotinine levels were used to determine in utero exposure to smoking. Cord serum mtDNA was measured by quantitative polymerase chain reaction analysis of the genes coding for cytochrome c oxidase1 (MT-CO1) and cytochrome c oxidase2 (MT-CO2). Log transformed levels of mtDNA coding for MT-CO1 and MT-CO2 were significantly higher among infants of active smokers with higher serum level of cotinine (p<0.05) and inversely associated with gestational age (p=0.08; p=0.02). Structural equation modeling results confirmed a positive association between cotinine and MT-CO1 and2 (p<0.01) and inverse associations with gestational age (p=0.02) and IGF-1 (p<0.01). We identified a dose-dependent increase in the level of MT-CO1 and MT-CO2 associated to increased cord serum cotinine and decreased gestational age.
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