The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance

Article Oncology

PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress

Marta Klopotowska et al.

Summary: Oxidative stress is a characteristic feature of cancer, and increased hydrogen peroxide concentrations affect immune cell functions. NK cells are more susceptible to hydrogen peroxide and lack peroxiredoxin-1.

CANCER IMMUNOLOGY RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer

Yan Deng et al.

Summary: High infiltration of M2-polarized macrophages in primary TNBC tumors is associated with poor prognosis. This study demonstrates that targeting SMS2 may be a novel therapeutic strategy for TNBC by inhibiting M2 macrophages polarization and tumor progression. Knockout of SMS2 or treatment with a specific SMS2 inhibitor resulted in reduced M2-type macrophages, tumor weight, and metastasis in a mouse model of TNBC, leading to an improved infiltration of antitumor immune cells.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Nutrition & Dietetics

Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial

Adeleh Khodabakhshi et al.

Summary: The study evaluated the effects of a ketogenic diet on breast cancer patients undergoing chemotherapy. Results showed a decrease in TNF-alpha and insulin, an increase in IL-10, and reductions in tumor size and staging in the ketogenic diet group.

CLINICAL NUTRITION (2021)

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Review Biotechnology & Applied Microbiology

Antibody-drug conjugates in metastatic triple negative breast cancer: a spotlight on sacituzumab govitecan, ladiratuzumab vedotin, and trastuzumab deruxtecan

Julia E. McGuinness et al.

Summary: SG, LV, and T-DXd have shown potential to significantly improve clinical outcomes in pretreated mTNBC patients, with notable response rates in phase I/II and phase III clinical trials. Investigation into their use in combination with other agents is ongoing, and their application in early-stage TNBCs is being explored. ADCs are anticipated to redefine treatment approaches in TNBC.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Article Biology

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Alyssa Vito et al.

Summary: The combination immunotherapy platform in triple negative breast cancer increases tumor-infiltrating lymphocytes and improves response to immune checkpoint blockade. B cells play a crucial role in antitumor immunity and modulate myeloid-derived suppressor cells.

COMMUNICATIONS BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice

Ruixin Sun et al.

Summary: This study demonstrates that the PARPi olaparib can significantly enhance the efficacy of CAR-T cells in breast cancer models by inhibiting MDSC migration, indicating a potential novel mechanism for combination therapy in breast cancer treatment.

MOLECULAR THERAPY (2021)

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Article Oncology

PPP2R2B downregulation is associated with immune evasion and predicts poor clinical outcomes in triple-negative breast cancer

Zheng Li et al.

Summary: The study identified PPP2R2B as a strong tumor suppressor in TNBC, with downregulated expression in TNBC tissues compared to normal breast tissues. Low PPP2R2B expression was associated with shorter survival time and could play a key role in breast cancer initiation and progression. PPP2R2B was also found to be related to specific immune cells and immune inhibitor genes.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors

Huanpeng Chen et al.

Summary: Chimeric antigen receptor (CAR) T cell therapy has been successful in treating lymphoma malignancies but less so in treating solid tumors. A study developed a CAR targeting Trop2 (T2-CAR) with different co-stimulatory intercellular domains and found that CD27-based T2-CAR T cells demonstrated higher antitumor activity in tumor-bearing mouse models. Additionally, CD27-based T2-CAR T cells were found to upregulate IL-7R alpha expression and downregulate PD-1 expression. These findings suggest that a CD27-based T2-CAR T cell approach may be suitable for clinical applications.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Oncology

Folate Receptor Beta Designates Immunosuppressive Tumor-Associated Myeloid Cells That Can Be Reprogrammed with Folate-Targeted Drugs

Gregory M. Cresswell et al.

Summary: The immunosuppressive environment within tumors limits the efficacy of immunotherapies, with MDSCs and TAMs playing a key role in hindering immune cell functions. Targeting the FRβ(+) subset of these cells with folate-linked drugs can reprogram them to enhance antitumorigenic responses, inhibit tumor growth, block metastasis, and improve overall survival without toxicity. This strategy has broad applications for the treatment of various tumors.

CANCER RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Margetuximab for the treatment of HER2-positive metastatic breast cancer

Paolo Tarantino et al.

Summary: The novel anti-HER2 agent margetuximab has demonstrated a slight improvement in progression-free survival compared to trastuzumab when combined with chemotherapy for pretreated HER2-positive advanced breast cancer. Its clinical role in the rapidly evolving landscape of HER2-positive breast cancer treatment should be considered in view of other emerging anti-HER2 agents. The development of margetuximab has significantly improved our biological understanding of HER2-positive breast cancer, emphasizing the importance of patient genotype and antibody-dependent cellular cytotoxicity in HER2-blockade context.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Review Biochemistry & Molecular Biology

A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses

Lea Clusan et al.

Summary: Breast cancer is the most common cancer among women worldwide. While most ER-positive breast cancer cases initially respond to antiestrogen therapies, a high percentage develop resistance over time. Research on mutated forms of ER alpha has led to potential developments in new antiestrogen treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation

Yuanzhang Fang et al.

Summary: Immune evasion is a critical event in tumor progression, and downregulation of antigen presentation by tumor cells is a primary mechanism of immune escape. The identification of MAL2 as a key player in enhancing antigen presentation on tumor cells and increasing cytotoxicity of immune cells suggests its potential as a therapeutic target for breast cancer immunotherapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

STING agonist promotes CAR T cell trafficking and in breast cancer

Nuo Xu et al.

Summary: The study demonstrates that enhancing CAR T cell therapy targeting solid tumors with STING agonists, specifically DMXAA, can greatly improve tumor control by promoting CAR T cell trafficking and persistence in the tumor microenvironment. The single-cell RNA sequencing results show that DMXAA generates a chemokine milieu that facilitates CART cell recruitment and modulates the immunosuppressive TME.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Oncology

A Phase II Clinical Trial of Pembrolizumab and Enobosarm in Patients with Androgen Receptor-Positive Metastatic Triple-Negative Breast Cancer

Yuan Yuan et al.

Summary: The study investigated the safety and efficacy of the combination of enobosarm and pembrolizumab in patients with AR+ metastatic TNBC. Despite showing a modest clinical benefit rate, the trial was stopped early due to the withdrawal of drug supply.

ONCOLOGIST (2021)

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Article Oncology

Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

Jiri Eitler et al.

Summary: NK cells mediate cytotoxicity by directing granule polarization and exocytosis towards the immunological synapse when encountering susceptible targets. Retargeting NK cells with CAR or FcR/mAb enhances granule polarization and overcomes tumor cell resistance through activation of the necessary signaling pathways such as PLC gamma and MEK/ERK.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

Pengxiang Yang et al.

Summary: Exosomes derived from CAR-T cells targeting MSLN showed potential in inhibiting the growth of MSLN-positive triple-negative breast cancer cells, with characteristics similar to parental T cells. The expression of effector molecules may contribute to tumor killing, and in vivo studies demonstrated a highly effective tumor inhibition rate with no obvious side effects. The use of CAR-T cell exosomes has promising therapeutic potential against MSLN-expressing TNBC.

CELLULAR IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Alba Rodriguez-Garcia et al.

Summary: The study demonstrates that targeting FR beta-expressing TAMs with CAR-T cells can enhance antitumor immune responses and improve the efficacy of adoptive T-cell therapy in pre-clinical models.

NATURE COMMUNICATIONS (2021)

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Article Immunology

IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

Siqi Guo et al.

Summary: The study demonstrates that IL-15/IL-15R alpha complex enhances CD8 T cell expansion and has potential efficacy in inhibiting breast cancer growth and improving cytotoxicity. Further research is needed to optimize the effectiveness of IL-15cx as an immunotherapy for breast cancer.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Karthik Dhatchinamoorthy et al.

Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy

Vincenzo Salemme et al.

Summary: The progression of breast cancer is influenced by genetic and epigenetic factors that involve interactions between tumor cells and the tumor microenvironment, particularly immune cells. Immune cells in the tumor microenvironment can have dual roles in cancer onset and progression, affecting both tumor suppression and promotion. Understanding the complex interplay between cancer and immune cells, as well as therapeutic strategies targeting this interaction, is crucial for developing effective combination treatments to overcome tumor immune evasion mechanisms and maximize the clinical benefits of current immunotherapies.

FRONTIERS IN ONCOLOGY (2021)

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Article

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses

Diana P. Saraiva et al.

Oncotarget (2021)

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Article Oncology

Impact of Anti-HER2 Treatments Combined With Atezolizumab on the Tumor Immune Microenvironment in Early or Metastatic Breast Cancer: Results From a Phase Ib Study

Erika P. Hamilton et al.

Summary: The combination of atezolizumab with targeted therapies may enhance antitumor activity in early-stage and metastatic HER2+ breast cancer, with manageable safety profiles. T-cell signatures and biomarkers of antitumor immunity differ between early-stage and metastatic tumors.

CLINICAL BREAST CANCER (2021)

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Article Oncology

A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3-Specific CAR T Cells in Solid Tumors

Xinyuan Lei et al.

Summary: The study demonstrated that the combination of SAHA and B7-H3.CAR T cells enhances the therapeutic efficacy against solid cancers, especially those with increased B7-H3 expression at the transcriptional level.

CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells

Nehal Gupta et al.

Summary: Atovaquone reduces the growth of triple-negative breast tumors by decreasing immunosuppressive cells, cytokines, and regulatory T cells in the tumor microenvironment, showing potential as an anticancer therapeutic strategy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Energy status dictates PD-L1 protein abundance and anti-tumor to enable blockade

Xiaoming Dai et al.

Summary: The ketogenic diet-induced changes in energy status were found to enhance the efficacy of anti-CTLA-4 immunotherapy through various mechanisms, such as decreasing PD-L1 protein levels and increasing expression of IFNs and antigen presentation genes. AMPK activation plays a crucial role in these mechanisms, highlighting its importance in regulating the immune response to immune checkpoint blockade.

MOLECULAR CELL (2021)

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Article Medicine, General & Internal

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

A. Bardia et al.

Summary: Patients with metastatic triple-negative breast cancer treated with Sacituzumab govitecan had significantly longer progression-free and overall survival compared to standard chemotherapy, but experienced more frequent myelosuppression and diarrhea as adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Oncology

Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition

Lin Xia et al.

Summary: The study revealed that immunosuppressive genes induced by EGFR CAR T cells were sensitive to a CDK7 inhibitor THZ1, which can overcome resistance in TNBC tumors. Combination therapy with THZ1 and EGFR CAR T cells suppressed immune resistance, tumor growth, and metastasis in TNBC tumor models. This suggests that transcriptional modulation using epigenetic inhibitors could offer a potential avenue for treating TNBC in the clinic.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Immunology

IFNγ Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation

Gabriel Goncalves et al.

Summary: Peptide vaccination is a promising strategy to induce T-cell mediated tumor killing. In this study, the effect of IFN gamma on TNBC cells was analyzed, revealing a significant remodeling of the immunopeptidome with increased diversity and abundance of peptides. The results suggest that cytokine stimulation can unveil a wider range of potential HLA-I and HLA-II vaccine targets, which has important implications for personalized cancer vaccination strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Microwave ablation induces Th1-type immune response with activation of ICOS pathway in early-stage breast cancer

Wenbin Zhou et al.

Summary: Microwave ablation (MWA) has shown a high complete ablation rate for early-stage breast cancer and induced a shift in the Th1/Th2 balance towards Th1, along with stimulating antitumor immune response. This suggests that MWA may not only be a promising local therapy for breast cancer but also trigger antitumor immunity, offering new avenues for treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

The Role of Macrophages in Cancer Development and Therapy

Ewa Cendrowicz et al.

Summary: Tumor-Associated Macrophages (TAMs) play a crucial role in tumor development and are potential targets for cancer therapy due to their influence on immunity and tumor microenvironment.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth

Maliha Tabassum Munir et al.

Summary: Breast cancer is the most common cancer in women in Western countries, with TAMs playing a key role in the breast cancer microenvironment and high TAM density being associated with poor prognosis. Altering TAM function may be a potential therapeutic target for treating breast cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels

Marie-Anne Goyette et al.

Summary: Inhibition of Axl leads to reduction of hypoxia-induced EMT, invasion, and cytokine production, creating a favorable environment for immunotherapy and reducing metastatic burden in HER2(+) breast cancer.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Immunology

Landscape of Immune Microenvironment Under Immune Cell Infiltration Pattern in Breast Cancer

Qianhui Xu et al.

Summary: This study comprehensively investigated the role of immune cell infiltration patterns in tumor progression and clinical outcomes in breast cancer. Different immune infiltration patterns were identified, with high ICI scores suggesting immune-exhausted phenotype and low ICI scores corresponding to immune-activated phenotype with potential immunotherapeutic advantage. The findings contribute to a better understanding of the complexity of the tumor immune microenvironment and could potentially optimize precision immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

Archana Thakur et al.

Summary: In this study, metabolically enhanced headless CAR T cells were generated by transducing specific signaling domains and arming with bispecific antibodies, which showed significant cytotoxicity and prolonged killing effect on solid tumor targets, while also maintaining efficacy under in vitro hypoxic conditions.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Evaluation of tumor immune contexture among intrinsic molecular subtypes helps to predict outcome in early breast cancer

Quentin Klopfenstein et al.

Summary: The prognosis of early breast cancer is associated with the clinic-pathological stage and the molecular characteristics of tumor cells. In some patients, the presence of tumor-infiltrating immune cells can impact long term outcome. A new gene expression deconvolution algorithm was developed to estimate immune cell populations in tumors and found that myeloid cells were associated with poor outcomes, while lymphoid cells were linked to favorable prognosis. This information, when combined with clinical stage and PAM50, can improve the prediction of relapse or death in early breast cancer patients.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer

Chongru Zhao et al.

Summary: Obesity is closely linked to breast cancer and can significantly impact the development and treatment of breast cancer.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities

Li Du et al.

Summary: The addition of IL-21 in CAR-T cell preparation was found to improve T cell transfection efficiency, enhance the enrichment and expansion of less differentiated CAR-T cells, and improve CAR-T cell cytotoxicity by promoting the secretion of effector cytokines.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Multidisciplinary Sciences

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

Ana L. Portillo et al.

Summary: The study shows that HER2 CAR-NK cells enhance anti-tumor functions against HER2-expressing cancer cells without affecting non-malignant cells, suggesting a promising and safe immunotherapy option for solid tumors.

ISCIENCE (2021)

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Review Biochemistry & Molecular Biology

Targeting macrophages in cancer immunotherapy

Zhaojun Duan et al.

Summary: Immunotherapy is considered the most promising treatment for cancers, with various strategies such as adoptive cellular immunotherapy, tumor vaccines, antibodies, immune checkpoint inhibitors, and small-molecule inhibitors showing success. The review highlights the role of macrophages in current immunotherapies and the potential benefits of targeting them, suggesting that therapeutic strategies involving macrophages have the potential to enhance the efficacy of cancer treatments.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, Research & Experimental

IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer

Wenjuan Gao et al.

Summary: IL20RA signaling pathway promotes stemness features of breast cancer cells, chemoresistance, tumor initiation, and metastasis, while altering the immune microenvironment by upregulating PD-L1 and reducing anti-cancer lymphocyte recruitment. Targeting IL20RA-hi population with STAT3 inhibition and anti-PD-L1 therapy enhances chemotherapeutic efficacy for breast cancer treatment.

THERANOSTICS (2021)

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Article Oncology

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer

Prahlad V. Raninga et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Oncology

A phase 2 clinical trialassessing theefficacy and safety of pembrolizumab and radiotherapy in patients with metastatic triple-negative breast cancer

Alice Y. Ho et al.

CANCER (2020)

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Article Oncology

GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells

Christian M. Seitz et al.

ONCOIMMUNOLOGY (2020)

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Article Oncology

Pembrolizumab plus chemotherapy as neoadjuvant treatment of high-risk, early-stage triple-negative breast cancer: results from the phase 1b open-label, multicohort KEYNOTE-173 study

P. Schmid et al.

ANNALS OF ONCOLOGY (2020)

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Article Engineering, Biomedical

Co-localized delivery of nanomedicine and nanovaccine augments the postoperative cancer immunotherapy by amplifying T-cell responses

Xiang Liu et al.

BIOMATERIALS (2020)

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Article Hematology

Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Huang Zhu et al.

BLOOD (2020)

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Article Oncology

Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells

Sanjay Varikuti et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

miRNA-5119 regulates immune checkpoints in dendritic cells to enhance breast cancer immunotherapy

Meng Zhang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Review Oncology

Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy

Malgorzata Firczuk et al.

CANCER LETTERS (2020)

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Article Cell Biology

Oncolytic adenovirus targeting TGF-β enhances anti-tumor responses of mesothelin-targeted chimeric antigen receptor T cell therapy against breast cancer

Yuxiang Li et al.

CELLULAR IMMUNOLOGY (2020)

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Article Oncology

A Phase II Study of Pembrolizumab in Combination With Palliative Radiotherapy for Hormone Receptor-positive Metastatic Breast Cancer

Romualdo Barroso-Sousa et al.

CLINICAL BREAST CANCER (2020)

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Article Immunology

CXCR2-modified CAR-T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

Guangna Liu et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Pembrolizumab for Early Triple-Negative Breast Cancer

Peter Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

R. K. Murthy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer

Shanu Modi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cell Biology

High-dose vitamin C enhances cancer immunotherapy

Alessandro Magri et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Recent Advances in Allogeneic CAR-T Cells

Dong Wook Kim et al.

BIOMOLECULES (2020)

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Article Multidisciplinary Sciences

Tissue factor as a new target for CAR-NK cell immunotherapy of triple-negative breast cancer

Zhiwei Hu

SCIENTIFIC REPORTS (2020)

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Article Biotechnology & Applied Microbiology

Engineered IL-7 Receptor Enhances the Therapeutic Effect of AXL-CAR-T Cells on Triple-Negative Breast Cancer

Zhenhui Zhao et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Oncology

TROPiCS-02: A Phase III study investigating sacituzumab govitecan in the treatment of HR+/HER2-metastatic breast cancer

Hope S. Rugo et al.

FUTURE ONCOLOGY (2020)

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Article Oncology

Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis

Justin Zonneville et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Oncology

Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study

Sandra M. Swain et al.

LANCET ONCOLOGY (2020)

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Review Immunology

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Alireza Labani-Motlagh et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer

Fang Bai et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Oncology

Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer

Tanja Stuber et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Oncology

PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations

Kellsye P. Fabian et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Oncology

All-Trans Retinoic Acid Stimulates Viral Mimicry, Interferon Responses and Antigen Presentation in Breast-Cancer Cells

Marco Bolis et al.

CANCERS (2020)

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Article Biotechnology & Applied Microbiology

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

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Review Cell Biology

γδ T Cells: The Ideal Tool for Cancer Immunotherapy

Mahboubeh Yazdanifar et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells

Malgorzata Bajor et al.

ANTIOXIDANTS (2020)

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Article Oncology

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

Devikala Gurusamy et al.

CANCER CELL (2020)

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Article Oncology

Trastuzumab derived HER2-specific CARs for the treatment of trastuzumab-resistant breast cancer: CAR T cells penetrate and eradicate tumors that are not accessible to antibodies

Arpad Szoor et al.

CANCER LETTERS (2020)

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Article Cell Biology

Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor

Yan Liu et al.

CELL PROLIFERATION (2020)

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Article Biology

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

Yvette Robbins et al.

ELIFE (2020)

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Review Oncology

The Great War of Today: Modifications of CAR-T Cells to Effectively Combat Malignancies

Andriy Zhylko et al.

CANCERS (2020)

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Review Oncology

Recent advances in CAR-T cell engineering

Ruihao Huang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Meeting Abstract Oncology

Tumour infiltrating lymphocytes (TILs), PD-L1 expression and their dynamics in the NeoTRIPaPDL1 trial

G. Bianchini et al.

ANNALS OF ONCOLOGY (2020)

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Article Oncology

Sacituzumab govitecan in previously treated hormone receptor-positive/HER2-negative metastatic breast cancer: fi nal results from a phase I/II, single-arm, basket trial

K. Kalinsky et al.

ANNALS OF ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Natural killer cells in cancer biology and therapy

Song-Yang Wu et al.

MOLECULAR CANCER (2020)

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Article Oncology

ARX788, a Site-specific Anti-HER2 Antibody-Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1-resistant Breast and Gastric Cancers

Lillian Skidmore et al.

MOLECULAR CANCER THERAPEUTICS (2020)

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Review Oncology

Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire

Sebastian P. Haen et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

Zhi-Ling Li et al.

NATURE COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8(+) T cell expansion

Catherine Olesch et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Oncology

The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors

Ravindra Pramod Deshpande et al.

CANCERS (2020)

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Article Oncology

Breast Cancer Cell-Neutrophil Interactions Enhance Neutrophil Survival and Pro-Tumorigenic Activities

Lingyun Wu et al.

CANCERS (2020)

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Article Oncology

The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer

Xiaochen Hu et al.

NEOPLASIA (2020)

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Efficacy and predictive factors of immune checkpoint inhibitors in metastatic breast cancer: a systematic review and meta-analysis

Yutian Zou et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

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Novel antibody-drug conjugates for triple negative breast cancer

Aiko Nagayama et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Tina Gruosso et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Alteration of specific cytokine expression patterns in patients with breast cancer

Kosuke Kawaguchi et al.

SCIENTIFIC REPORTS (2019)

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A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study

S. Loibl et al.

ANNALS OF ONCOLOGY (2019)

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Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo

Yu Cao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

Leonie Voorwerk et al.

NATURE MEDICINE (2019)

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Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

Yushu Joy Xie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Target selection for CAR-T therapy

Jianshu Wei et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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PD-1/PD-L1 Targeting in Breast Cancer: The First Clinical Evidences are Emerging-A Literature Review

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CANCERS (2019)

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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients

Nadia Viborg et al.

ONCOIMMUNOLOGY (2019)

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Selenium nanoparticles as new strategy to potentiate γδ T cell anti-tumor cytotoxicity through upregulation of tubulin-α acetylation

Yi Hu et al.

BIOMATERIALS (2019)

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Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors

Rachel Grosser et al.

CANCER CELL (2019)

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An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

Yin Wu et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer

Katsiaryna Marhelava et al.

CANCERS (2019)

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Immune Tumor Microenvironment in Breast Cancer and the Participation of Estrogens and Its Receptors Into Cancer Physiopathology

Mariana Segovia-Mendoza et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Tumor-associated macrophages: an accomplice in solid tumor progression

Yibing Chen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

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CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment

Marina Martinez et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Tumor-infiltrating B cells signal functional humoral immune responses in breast cancer

Soizic Garaud et al.

JCI INSIGHT (2019)

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Mechanisms of immune evasion in breast cancer

Joshua P. Bates et al.

BMC CANCER (2018)

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Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for non-small cell lung cancer patients

Ronny Ben-Avi et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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Tumour growth and immune evasion as targets for a new strategy in advanced cancer

Andrea Nicolini et al.

ENDOCRINE-RELATED CANCER (2018)

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The breast tumor microenvironment: role in cancer development, progression and response to therapy

Suruchi Mittal et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

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Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer

Antonino Bruno et al.

FASEB JOURNAL (2018)

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Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T

Dok Hyun Yoon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Chimeric Antigen Receptor Therapy

Carl H. June et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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CAR T cell immunotherapy for human cancer

Carl H. June et al.

SCIENCE (2018)

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CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Pradip Bajgain et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

Malgorzata Bajor et al.

BRITISH JOURNAL OF CANCER (2018)

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ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer

Sushil Kumar et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

P. Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

Kim Ohl et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Inflammatory breast cancer biology: the tumour microenvironment is key

Bora Lim et al.

NATURE REVIEWS CANCER (2018)

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Dendritic Cell Vaccination Enhances Immune Responses and Induces Regression of HER2pos DCIS Independent of Route: Results of Randomized Selection Design Trial

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CLINICAL CANCER RESEARCH (2017)

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Immune infiltrates in the breast cancer microenvironment: detection, characterization and clinical implication

Samantha Burugu et al.

BREAST CANCER (2017)

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Neutrophils as active regulators of the immune system in the tumor microenvironment

Merav E. Shaul et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

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Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective

Isabelle Riviere et al.

MOLECULAR THERAPY (2017)

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Engineering Natural Killer Cells for Cancer Immunotherapy

Katayoun Rezvani et al.

MOLECULAR THERAPY (2017)

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Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

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Tumour-infiltrating lymphocytes and the emerging role of immunotherapy in breast cancer

Stephen J. Luen et al.

PATHOLOGY (2017)

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Mechanism of immune evasion in breast cancer

Mozhi Wang et al.

ONCOTARGETS AND THERAPY (2017)

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HLA-mediated tumor escape mechanisms that may impair immunotherapy clinical outcomes via T-cell activation

Josefa A. Rodriguez

ONCOLOGY LETTERS (2017)

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Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer

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ONCOTARGET (2017)

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Prognostic value of tumor-infiltrating Foxp3+regulatory T cells in patients with breast cancer: a meta-analysis

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JOURNAL OF CANCER (2017)

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Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

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CANCER IMMUNOLOGY RESEARCH (2017)

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Cancer-promoting mechanisms of tumor-associated neutrophils

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AMERICAN JOURNAL OF SURGERY (2017)

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Clinicopathological and prognostic significance of programmed death ligand-1 expression in breast cancer: a meta-analysis

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BMC CANCER (2017)

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Markers and Function of Human NK Cells in Normal and Pathological Conditions

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CYTOMETRY PART B-CLINICAL CYTOMETRY (2017)

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Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis

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BREAST CANCER RESEARCH (2017)

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CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity

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Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression

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ONCOTARGET (2016)

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Th1 Immune Response Induction by Biogenic Selenium Nanoparticles in Mice with Breast Cancer: Preliminary Vaccine Model

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Iranian Journal of Biotechnology (2016)

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PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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BREAST CARE (2016)

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Deubiquitination and Stabilization of PD-L1 by CSN5

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CANCER CELL (2016)

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Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer

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CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

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Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models

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CANCER RESEARCH (2016)

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Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: A systematic review and meta-analysis

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CANCER TREATMENT REVIEWS (2016)

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DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

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CLINICAL CANCER RESEARCH (2016)

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Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

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CANCER DISCOVERY (2016)

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Clinical significance of tumor-infiltrating lymphocytes in breast cancer

Sasha E. Stanton et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)

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Targeting HER2 for the Treatment of Breast Cancer

Mothaffar F. Rimawi et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

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Utility of pre-treatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in breast cancer

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BRITISH JOURNAL OF CANCER (2015)

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Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis

Haiming Yu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

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Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer

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EUROPEAN JOURNAL OF CLINICAL NUTRITION (2015)

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Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus-Targeted Tumor-Infiltrating T Cells

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JOURNAL OF CLINICAL ONCOLOGY (2015)

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Role of the Tumor Microenvironment in Breast Cancer

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PATHOBIOLOGY (2015)

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Characterization of tumor infiltrating Natural Killer cell subset

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ONCOTARGET (2015)

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Characterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer

Maija Hollmen et al.

SCIENTIFIC REPORTS (2015)

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Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor

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MOLECULAR THERAPY (2014)

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Association between CD8+T-cell infiltration and breast cancer survival in 12 439 patients

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ANNALS OF ONCOLOGY (2014)

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Trafficking of T Cells into Tumors

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CANCER RESEARCH (2014)

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Trastuzumab Emtansine: A Novel Antibody-Drug Conjugate for HER2-Positive Breast Cancer

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CLINICAL CANCER RESEARCH (2014)

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Overexpression of MAGE-A9 predicts unfavorable outcome in breast cancer

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EXPERIMENTAL AND MOLECULAR PATHOLOGY (2014)

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Noncanonical NF-κB Activation Mediates STAT3-Stimulated IDO Upregulation in Myeloid-Derived Suppressor Cells in Breast Cancer

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JOURNAL OF IMMUNOLOGY (2014)

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Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

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CANCER IMMUNOLOGY RESEARCH (2014)

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Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells

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BREAST CANCER RESEARCH AND TREATMENT (2013)

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Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer

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CLINICAL CANCER RESEARCH (2013)

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Sleeping Beauty System to Redirect T-cell Specificity for Human Applications

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JOURNAL OF IMMUNOTHERAPY (2013)

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Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor

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MOLECULAR THERAPY (2013)

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Hydrazinocurcumin Encapsuled Nanoparticles Re-Educate Tumor-Associated Macrophages and Exhibit Anti-Tumor Effects on Breast Cancer Following STAT3 Suppression (Publication with Expression of Concern. See vol. 14, 2019)

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PLOS ONE (2013)

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High-Infiltration of Tumor-Associated Macrophages Predicts Unfavorable Clinical Outcome for Node-Negative Breast Cancer

Yue Zhang et al.

PLOS ONE (2013)

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Tumor-Associated Antigens in Breast Cancer

Carmen Criscitiello

BREAST CARE (2012)

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Impaired IFN-α Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

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CANCER RESEARCH (2012)

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Systematic Review of Cancer Presentations with a Median Survival of Six Months or Less

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JOURNAL OF PALLIATIVE MEDICINE (2012)

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Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

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CANCER CELL (2011)

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Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

Purevdorj B. Olkhanud et al.

CANCER RESEARCH (2011)

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Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

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CLINICAL CANCER RESEARCH (2011)

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Article Cell & Tissue Engineering

A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer

Melissa A. Geller et al.

CYTOTHERAPY (2011)

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Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

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JOURNAL OF CLINICAL ONCOLOGY (2011)

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Stimulated γδ T Cells Increase the In Vivo Efficacy of Trastuzumab in HER-2+ Breast Cancer

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JOURNAL OF IMMUNOLOGY (2011)

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Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation

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JOURNAL OF LEUKOCYTE BIOLOGY (2011)

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Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial

Soyoung Baek et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

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HER2 and hormone receptor-positive breast cancer-blocking the right target

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NATURE REVIEWS CLINICAL ONCOLOGY (2011)

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Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer

Nathan R. West et al.

BREAST CANCER RESEARCH (2011)

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Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers

Max Yan et al.

BREAST CANCER RESEARCH (2011)

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Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells

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FASEB JOURNAL (2010)

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B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice

David J. DiLillo et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Biochemistry & Molecular Biology

Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth

A. McGarry Houghton et al.

NATURE MEDICINE (2010)

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Triple-Negative Breast Cancer

William D. Foulkes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Anti-tumour activity of bisphosphonates in preclinical models of breast cancer

Ingunn Holen et al.

BREAST CANCER RESEARCH (2010)

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T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

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BLOOD (2009)

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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

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CANCER CELL (2009)

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Possible involvement of regulatory T cells in tumor onset and progression in primary breast cancer

Masahiro Ohara et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2009)

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Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target

Sandra D. Bohling et al.

MODERN PATHOLOGY (2008)

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Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice

Clifford A. Hudis

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Article Biochemistry & Molecular Biology

Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity

Huang-Ge Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

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Article Biochemistry & Molecular Biology

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

TJ Curiel et al.

NATURE MEDICINE (2004)

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Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses

D Avigan et al.

CLINICAL CANCER RESEARCH (2004)

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SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

M Uhl et al.

CANCER RESEARCH (2004)

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Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma:: possible association with suppression of micrometastasis

T Chiba et al.

BRITISH JOURNAL OF CANCER (2004)

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Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes

EM Neidhardt-Berard et al.

BREAST CANCER RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Immunoproteasome assembly and antigen presentation in mice lacking both PA28α and PA28β

S Murata et al.

EMBO JOURNAL (2001)

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The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance

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