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Comprehensive molecular characterization of human colon and rectal cancer
Donna M. Muzny et al.
NATURE (2012)
TGFβ signalling in context
Joan Massague
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Smad phosphoisoform signaling specificity: the right place at the right time
Koichi Matsuzaki
CARCINOGENESIS (2011)
CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial-Mesenchymal Transition in HCC Cells
Ai-Wu Ke et al.
GASTROENTEROLOGY (2011)
Autophagy-deficient mice develop multiple liver tumors
Akito Takamura et al.
GENES & DEVELOPMENT (2011)
Transforming Growth Factor-β Adaptor, β2-Spectrin, Modulates Cyclin Dependent Kinase 4 to Reduce Development of Hepatocellular Cancer
Hye Jung Baek et al.
HEPATOLOGY (2011)
The Transforming Growth Factor-Beta (TGF-β) Mediates Acquisition of a Mesenchymal Stem Cell-Like Phenotype in Human Liver Cells
Laia Caja et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Epithelial-mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death?
Massimo Pinzani
JOURNAL OF HEPATOLOGY (2011)
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Philip A. Gregory et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang et al.
NATURE (2011)
Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis
Kang-Jie Chen et al.
PLOS ONE (2011)
The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets
Ju Dong Yang et al.
SEMINARS IN CANCER BIOLOGY (2011)
Cross Talk among TGF-β Signaling Pathways, Integrins, and the Extracellular Matrix
John S. Munger et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Suppression of Glypican 3 Inhibits Growth of Hepatocellular Carcinoma Cells through Up-Regulation of TGF-β2
Chris K. Sun et al.
NEOPLASIA (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Regulation of autophagy by transforming growth factor-β (TGFβ) signaling
Hiroshi I. Suzuki et al.
AUTOPHAGY (2010)
Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
Agustin Chicas et al.
CANCER CELL (2010)
Hallmarks of cancer: Interactions with the tumor stroma
Kristian Pietras et al.
EXPERIMENTAL CELL RESEARCH (2010)
Epigenetic Regulation of Cancer Stem Cell Marker CD133 by Transforming Growth Factor-β
Hanning You et al.
HEPATOLOGY (2010)
Transforming Growth Factor-Beta Induces Senescence in Hepatocellular Carcinoma Cells and Inhibits Tumor Growth
Serif Senturk et al.
HEPATOLOGY (2010)
Epigenetic Silencing of β-Spectrin, a TGF-β Signaling/Scaffolding Protein in a Human Cancer Stem Cell Disorder BECKWITH-WIEDEMANN SYNDROME
Zhi-Xing Yao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Epithelial-mesenchymal transitions and hepatocarcinogenesis
Janice Jou et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Hepatocellular carcinoma: a global view
Ju Dong Yang et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)
TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
B. Wang et al.
ONCOGENE (2010)
TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Zhan Yao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Regulation of TGF-beta signaling by Smad7
Xiaohua Yan et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2009)
Complex and Context Dependent Regulation of Hematopoiesis by TGF-beta Superfamily Signaling
Sofie Singbrant Soderberg et al.
HEMATOPOIETIC STEM CELLS VII (2009)
Senescence and immortality in hepatocellular carcinoma
Mehmet Ozturk et al.
CANCER LETTERS (2009)
Autophagy Is Activated by TGF-β and Potentiates TGF-β-Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells
Kunihiko Kiyono et al.
CANCER RESEARCH (2009)
Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
Thomas Amann et al.
CANCER SCIENCE (2009)
Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
Claudio Alarcon et al.
CELL (2009)
Autophagy Suppresses Tumorigenesis through Elimination of p62
Robin Mathew et al.
CELL (2009)
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery et al.
CELL (2009)
Phospho-control of TGF-beta superfamily signaling
Katharine H. Wrighton et al.
CELL RESEARCH (2009)
Signaling cross-talk between TGF-beta/BMP and other pathways
Xing Guo et al.
CELL RESEARCH (2009)
Targeting Transforming Growth Factor (TGF)-βRI Inhibits Activation of β1 Integrin and Blocks Vascular Invasion in Hepatocellular Carcinoma
Emilia Fransvea et al.
HEPATOLOGY (2009)
Hepatitis B Virus X Protein Shifts Human Hepatic Transforming Growth Factor (TGF)-β Signaling from Tumor Suppression to Oncogenesis in Early Chronic Hepatitis B
Miki Murata et al.
HEPATOLOGY (2009)
Inhibition of c-Jun NH2-Terminal Kinase Switches Smad3 Signaling from Oncogenesis to Tumor-Suppression in Rat Hepatocellular Carcinoma
Hiromitsu Nagata et al.
HEPATOLOGY (2009)
Transforming Growth Factor-Beta 1 (TGF-β1) Induces Angiogenesis Through Vascular Endothelial Growth Factor (VEGF)-Mediated Apoptosis
Giovanni Ferrari et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-beta 1
Hequan Li et al.
JOURNAL OF IMMUNOLOGY (2009)
Transforming growth factor β as a therapeutic target in systemic sclerosis
John Varga et al.
NATURE REVIEWS RHEUMATOLOGY (2009)
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
Wei-Lei Yang et al.
SCIENCE (2009)
Dysregulation of apoptosis in hepatocellular carcinoma cells
Isabel Fabregat
WORLD JOURNAL OF GASTROENTEROLOGY (2009)
NF-κB as a Critical Link Between Inflammation and Cancer
Michael Karin
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
TGFβ-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2
Sneha Ramesh et al.
EMBO REPORTS (2008)
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
Jae-Sung Kim et al.
HEPATOLOGY (2008)
Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
Cedric Coulouarn et al.
HEPATOLOGY (2008)
Upregulation of miR-23a∼27a∼24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells
Shenglin Huang et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Expression and clinical significance of the stem cell marker CD133 in hepatocellular carcinoma
W. Song et al.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2008)
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity
Irene Carmona-Cuenca et al.
JOURNAL OF HEPATOLOGY (2008)
Transforming growth factor-β-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between smad proteins and activator protein-1
Kerstin Herzer et al.
MOLECULAR CANCER RESEARCH (2008)
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
Davide Melisi et al.
MOLECULAR CANCER THERAPEUTICS (2008)
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β
Motozo Yamashita et al.
MOLECULAR CELL (2008)
The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Philip A. Gregory et al.
NATURE CELL BIOLOGY (2008)
The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
Alessandro Sorrentino et al.
NATURE CELL BIOLOGY (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Sorafenib in advanced hepatocellular carcinoma
Josep M. Llovet et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species
Dalliah Black et al.
BIOCHIMIE (2007)
Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation
K. Kitisin et al.
ONCOGENE (2007)
Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor β signaling, promoting cirrhosis and hepatocellular carcinoma
Koichi Matsuzaki et al.
HEPATOLOGY (2007)
PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression
A. N. M. Fischer et al.
ONCOGENE (2007)
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
Suntaek Hong et al.
NATURE IMMUNOLOGY (2007)
IL-2 is essential for TGF-β to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
Song Guo Zheng et al.
JOURNAL OF IMMUNOLOGY (2007)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis
A. R. Ramjaun et al.
ONCOGENE (2007)
SRF is a nuclear repressor of Smad3-mediated TGF-beta signaling
H-J Lee et al.
ONCOGENE (2007)
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
Suping Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer
Katenna Pardali et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2007)
Survival and apoptosis: a dysregulated balance in liver cancer
Isabel Fabregat et al.
LIVER INTERNATIONAL (2007)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Caspase function in programmed cell death
S. Kumar
CELL DEATH AND DIFFERENTIATION (2007)
Involvement of programmed cell death 4 in transforming growth factor-β1-induced apoptosis in human hepatocellular carcinoma
H. Zhang et al.
ONCOGENE (2006)
Transforming growth factor β suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene
He Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A FoxO-Smad synexpression group in human keratinocytes
Roger R. Gomis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Kurt Degenhardt et al.
CANCER CELL (2006)
Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
Yu-An Yang et al.
CANCER CELL (2006)
Autophagic programmed cell death by selective catalase degradation
L Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
TGF-β requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+ CD25+ regulatory cells
Song Guo Zheng et al.
JOURNAL OF IMMUNOLOGY (2006)
Laminin-5 (laminin-332): Unique biological activity and role in tumor growth and invasion
K Miyazaki
CANCER SCIENCE (2006)
Hepatocellular carcinoma pathogenesis: from genes to environment
Paraskevi A. Farazi et al.
NATURE REVIEWS CANCER (2006)
X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor β1 (TGF-β1) through ubiquitin-mediated proteosomal degradation of the TGF-β1-activated kinase 1 (TAK1)
S Kaur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
G Giannelli et al.
GASTROENTEROLOGY (2005)
Autophagy and signaling: their role in cell survival and cell death
P Codogno et al.
CELL DEATH AND DIFFERENTIATION (2005)
The G protein-coupled receptor kinase-2 is a TGFβ-inducible antagonist of TGFβ signal transduction
J Ho et al.
EMBO JOURNAL (2005)
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes
MM Murillo et al.
ONCOGENE (2005)
Inactivation of TGF-β signaling in hepatocytes results in an increased proliferative response after partial hepatectomy
J Romero-Gallo et al.
ONCOGENE (2005)
Targeting TGFβ signaling for cancer therapy
S Iyer et al.
CANCER BIOLOGY & THERAPY (2005)
Integration of Smad and Forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
J Seoane et al.
CELL (2004)
p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-β-mediated G1 arrest through modulation of IL-2 responsiveness
LA Wolfraim et al.
JOURNAL OF IMMUNOLOGY (2004)
Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes
B Herrera et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
New insights into TGF-β-Smad signalling
P ten Dijke et al.
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
WJ Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
ZY Yue et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Transforming growth factor-β-induced apoptosis is mediated by SMad-dependent expression of GADD45b through p38 activation
JY Yoo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Smad-dependent and Smad-independent pathways in TGF-β family signalling
R Derynck et al.
NATURE (2003)
Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
B Yang et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
The transforming activity of ski and SnoN is dependent on their ability to repress the activity of Smad proteins
J He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma
H Okano et al.
LABORATORY INVESTIGATION (2003)
Multiple tumor suppressor pathways negatively regulate telomerase
SY Lin et al.
CELL (2003)
ADAM12 in human liver cancers:: TGF-β-regulated expression in stellate cells is associated with matrix remodeling
H Le Pabic et al.
HEPATOLOGY (2003)
Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGFβ1
O Hashimoto et al.
MOLECULAR CARCINOGENESIS (2003)
Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice
Y Tang et al.
SCIENCE (2003)
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
H Valderrama-Carvajal et al.
NATURE CELL BIOLOGY (2002)
Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines:: association of transforming growth factor β1 (TGF-β1)-mediated p27Kip1 expression
G Yoon et al.
BIOCHEMICAL JOURNAL (2002)
Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
P Levéen et al.
BLOOD (2002)
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
SU Wiemann et al.
FASEB JOURNAL (2002)
TGF-β is required for programmed cell death in interdigital webs of the developing mouse limb
N Dünker et al.
MECHANISMS OF DEVELOPMENT (2002)
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase
CW Jang et al.
NATURE CELL BIOLOGY (2002)
Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells
BC Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor β in rat fetal hepatocytes
B Herrera et al.
HEPATOLOGY (2001)
TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
R Perlman et al.
NATURE CELL BIOLOGY (2001)
Cross-talk between IL-6 and TGF-β signaling in hepatoma cells
T Yamamoto et al.
FEBS LETTERS (2001)
Retention of mutant α1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response
JH Teckman et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
TGFβ signaling in growth control, cancer, and heritable disorders
J Massagué et al.
CELL (2000)
A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest
GF Claassen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Downregulation of proapoptotic proteins Bax and Bcl-Xs in p53 overexpressing hepatocellular carcinomas
W Beerheide et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Local control of the immune response in the liver
PA Knolle et al.
IMMUNOLOGICAL REVIEWS (2000)