4.6 Review

Progression in Ph-Chromosome-Negative Myeloproliferative Neoplasms: An Overview on Pathologic Issues and Molecular Determinants

Related references

Note: Only part of the references are listed.
Article Oncology

Clinical Significance of Bone Marrow Blast Percentage in Patients With Myelofibrosis and the Effect of Ruxolitinib Therapy

Lucia Masarova et al.

Summary: The study analyzed the outcomes of 1412 patients with myelofibrosis based on bone marrow blasts and exposure to ruxolitinib (RUX). Patients with 5% to 9% blasts had adverse clinical course but benefited from RUX treatment.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2021)

Article Hematology

Combination of myeloproliferative neoplasm driver gene activation with mutations of splice factor or epigenetic modifier genes increases risk of rapid blastic progression

Stephan Bartels et al.

Summary: This study found that ARCH/CHIP-associated mutations (TET2, ASXL1, DNMT3A) are not significantly associated with blastic transformation in MPN. On the other hand, mutations in SRSF2, U2AF1, and IDH1/2 when detected at first presentation are independent risk factors for rapid blast transformation of MPN.

EUROPEAN JOURNAL OF HAEMATOLOGY (2021)

Article Medicine, General & Internal

Impact of Integrated Genetic Information on Diagnosis and Prognostication for Myeloproliferative Neoplasms in the Next-Generation Sequencing Era

Jong-Mi Lee et al.

Summary: This study analyzed the genomic landscapes of 200 patients with myeloproliferative neoplasms (MPNs) and found high mutation rates in JAK2, CALR, and MPL genes. Co-occurring genetic aberrations potentially associated with phenotype and/or disease progression were detected. Specific genetic aberrations such as TP53 and -7/del(7q) were associated with patient outcomes like a lower chance of survival and leukemic transformation. Additionally, mutation-enhanced prognostic scoring systems were found to better predict patient outcomes.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Hematology

Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study

Damien Luque Paz et al.

Summary: This study identified four genomic groups associated with the prognosis of myelofibrosis, with TP53 and high-risk groups showing significant associations with leukemic transformation and death from myelofibrosis. ASXL1 mutations alone were found to have no prognostic value but worsened the prognosis when associated with other high-risk mutations.

BLOOD ADVANCES (2021)

Review Hematology

Leukemia secondary to myeloproliferative neoplasms

Andrew J. Dunbar et al.

BLOOD (2020)

Review Oncology

Next-Generation Sequencing in Myeloproliferative Neoplasms: Is This Indicated in All Patients?

Alain Antoine Mina et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2019)

Review Oncology

Myelofibrosis in 2019: moving beyond JAK2 inhibition

Michael Schieber et al.

BLOOD CANCER JOURNAL (2019)

Article Medicine, Research & Experimental

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

Anna Sophia McKenney et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, General & Internal

Classification and Personalized Prognosis in Myeloproliferative Neoplasms

J. Grinfeld et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Hematology

Polycythemia vera and essential thrombocythemia: algorithmic approach

Alessandro M. Vannucchi et al.

CURRENT OPINION IN HEMATOLOGY (2018)

Article Hematology

Bone marrow findings in blast phase of polycythemia vera

Juliana E. Hidalgo Lopez et al.

ANNALS OF HEMATOLOGY (2018)

Letter Hematology

Monocytosis is a powerful and independent predictor of inferior survival in primary myelofibrosis

Ayalew Tefferi et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Review Hematology

Myeloproliferative neoplasms: from origins to outcomes

Jyoti Nangalia et al.

BLOOD (2017)

Article Hematology

Monocytosis in polycythemia vera: Clinical and molecular correlates

Daniela Barraco et al.

AMERICAN JOURNAL OF HEMATOLOGY (2017)

Article Hematology

Targeted deep sequencing in primary myelofibrosis

Ayalew Tefferi et al.

BLOOD ADVANCES (2016)

Review Pathology

Acute Myeloid Leukemia and Other Types of Disease Progression in Myeloproliferative Neoplasms

Magdalena Czader et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2015)

Article Multidisciplinary Sciences

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Raajit Rampal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Oncology

Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

Alfonso Quintas-Cardama et al.

CLINICAL CANCER RESEARCH (2013)

Letter Hematology

Two novel NPM1 mutations in an acute myeloid leukemia patient transformed from primary myelofibrosis

S. H. Park et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2013)

Article Oncology

Mutations and prognosis in primary myelofibrosis

A. M. Vannucchi et al.

LEUKEMIA (2013)

Article Medicine, General & Internal

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Thorsten Klampfl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Hematology

Prognostic factors for thrombosis, myelofibrosis, and leukemia in essential thrombocythemia: a study of 605 patients

Francesco Passamonti et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2008)

Article Hematology

Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation

Naseema Gangat et al.

BRITISH JOURNAL OF HAEMATOLOGY (2007)