Transformed Lymphoma Is Associated with a Favorable Response to CAR-T-Cell Treatment in DLBCL Patients

Letter Medicine, General & Internal

Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy

Elise A. Chong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Oncology

Adoptive Immunotherapy beyond CAR T-Cells

Aleksei Titov et al.

Summary: The aging global population is leading to an increase in cancer-related morbidity and mortality, with late-stage tumor treatment becoming a significant burden on healthcare systems. Adoptive cell immunotherapy, particularly CAR T-cell technology, shows promise in curing previously incurable patients with B-cell malignancies, although challenges remain in treating solid tumors. Advanced cell therapies are being developed to address these challenges and improve the efficacy of cancer treatment.

CANCERS (2021)

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Article Oncology

Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study

Stephen J. Schuster et al.

Summary: The JULIET trial evaluated the long-term treatment outcomes and safety of tisagenlecleucel in adult patients, showing durable activity and manageable safety profiles in patients with relapsed or refractory aggressive B-cell lymphomas. Tisagenlecleucel compared favorably with conventional therapeutic approaches for patients with large B-cell lymphomas that are refractory to chemoimmunotherapy or relapsing after second-line therapies.

LANCET ONCOLOGY (2021)

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Article Hematology

CRP and ferritin in addition to the EASIX score predict CAR-T-related toxicity

Uri Greenbaum et al.

Summary: The EASIX score and other laboratory parameters collected before lymphodepletion can predict CAR-T cell therapy-related toxicities, aiding in clinical decisions such as preemptive toxicity management, hospitalization length, and appropriate setting for CAR-T administration.

BLOOD ADVANCES (2021)

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Review Oncology