4.6 Review

A Brief Overview of Radiation-Induced Effects on Spermatogenesis and Oncofertility

Related references

Note: Only part of the references are listed.
Article Radiology, Nuclear Medicine & Medical Imaging

Radiobiology of the FLASH effect

Anna A. Friedl et al.

Summary: Studies have shown differential radiobiological responses to ultrahigh dose rate (UHDR) radiation exposures compared to conventional dose rates, leading to exploration of the therapeutic advantages of FLASH-RT. The underlying molecular and cellular mechanisms of the FLASH effect remain to be fully elucidated.

MEDICAL PHYSICS (2022)

Article Oncology

Higher reproductive concerns associated with fertility consultation: a cross-sectional study of young adult male cancer survivors

Julia H. Drizin et al.

Summary: The study found that young adult male cancer survivors who received fertility consultation had higher levels of reproductive concerns. They were particularly concerned about fertility potential, achieving pregnancy, their (potential) child's health, and disclosing infertility to a partner, while no associations were observed regarding personal health concerns and acceptance of infertility.

SUPPORTIVE CARE IN CANCER (2021)

Article Obstetrics & Gynecology

Fertility-a human right worthy of mandated insurance coverage: the evolution, limitations, and future of access to care

Jennifer F. Kawwass et al.

Summary: State infertility mandates in the United States have varying qualifications and requirements, leading to disparities in access to care for certain groups; despite the increasing number of states with mandates, significant gaps remain in implementation and access; advocacy by providers, patients, and legislators is needed to expand insurance coverage and maximize reproductive outcomes.

FERTILITY AND STERILITY (2021)

Article Biochemistry & Molecular Biology

Differential Effects of Low and High Radiation Dose Rates on Mouse Spermatogenesis

Min Ji Bae et al.

Summary: The study revealed that the radiation dose rate has different effects on the testes of mice. Low dose rate radiation caused more severe tissue toxicity and adverse effects on sperm production compared to high dose rate radiation. This suggests that the dose rate of radiation may have differential impacts on different organs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors

Laura Eling et al.

Summary: The innovative irradiation technique of Microbeam Radiation Therapy has shown promising results in treating brain cancer with minimal impact on normal tissues. By delivering high-radiation doses through multiple arrays of synchrotron X-ray microbeams, this method has demonstrated significant improvements in tumor control and survival rates in preclinical studies. The unique benefits of multiport MRT, such as minimal normal tissue damage and exceptional tumor control, highlight its potential for clinical translation in neuro-oncology patients.

CANCERS (2021)

Article Oncology

A Multi-Scale and Multi-Technique Approach for the Characterization of the Effects of Spatially Fractionated X-ray Radiation Therapies in a Preclinical Model

Mariele Romano et al.

Summary: This study used a multi-technique approach to analyze the effects of different radiotherapy techniques on healthy and GBM brain tissues, providing a first-time 3D visualization and morphological analysis, as well as quantification and full-organ visualization of tumor volumes and calcium/iron deposits. The multi-scale and multi-technique approach enabled detailed visualization and classification in 3D of the radio-induced effects on brain tissues, bringing new essential information towards the clinical implementation of MRT and MB radiation therapy techniques.

CANCERS (2021)

Article Multidisciplinary Sciences

Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident

Meredith Yeager et al.

Summary: Research on children born to parents exposed to radiation from the Chernobyl nuclear accident did not show an increase in germline de novo mutations. This suggests that exposure to ionizing radiation may have minimal impact on genetic mutations in humans within the tested range.

SCIENCE (2021)

Article Oncology

A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

H. Fukunaga et al.

Summary: Microbeam radiotherapy (MRT) delivers spatially fractionated beams with the potential to improve the therapeutic ratio through micron-sized high dose and dose rate beams. The biological mechanisms underlying MRT efficacy are still unclear, involving vascular, bystander, stem cell, and potential immune responses. There is likely significant overlap in the mechanisms of MRT and FLASH radiotherapy that requires further investigation.

CLINICAL ONCOLOGY (2021)

Article Biology

Stem Cell Migration: A Possible Mechanism for the Tissue-Sparing Effect of Spatially Fractionated Radiation COMMENT

Hisanori Fukunaga

Summary: This article discusses the importance of stem cell responses in tissues after radiation exposure and the contributions of microbeam research to SFRT. It suggests that microbeam approaches can help uncover the mechanisms of tissue response, improve the outcomes of SFRT, and reduce its adverse effects. Studies have shown that stem cell survival, migration, and repopulation play a crucial role in tissue-level changes during or after SFRT.

RADIATION RESEARCH (2021)

Article Multidisciplinary Sciences

Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring

Adetunji P. Fayomi et al.

SCIENCE (2019)

Article Oncology

Treatment of a first patient with FLASH-radiotherapy

Jean Bourhis et al.

RADIOTHERAPY AND ONCOLOGY (2019)

Article Multidisciplinary Sciences

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Hisanori Fukunaga et al.

SCIENTIFIC REPORTS (2019)

Review Andrology

Radiation effects on male fertility

F. De Felice et al.

ANDROLOGY (2019)

Review Medicine, General & Internal

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

Hisanori Fukunaga et al.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Biology

Microbeam evolution: from single cell irradiation to pre-clinical studies

Mihaela Ghita et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2018)

Article Oncology

Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update

Kutluk Oktay et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Article Public, Environmental & Occupational Health

Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors' Offspring

Kotaro Ozasa et al.

JOURNAL OF EPIDEMIOLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Faster and safer? FLASH ultra-high dose rate in radiotherapy

Marco Durante et al.

BRITISH JOURNAL OF RADIOLOGY (2018)

Article Environmental Sciences

SPACE: THE FINAL FRONTIER-RESEARCH RELEVANT TO MARS

John D. Boice

HEALTH PHYSICS (2017)

Review Biology

Low-dose radiation-induced risk in spermatogenesis

Hisanori Fukunaga et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

Microbeam radiation therapy - grid therapy and beyond: a clinical perspective

Elisabeth Schuelke et al.

BRITISH JOURNAL OF RADIOLOGY (2017)

Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Genetics & Heredity

Roles for mismatch repair family proteins in promoting meiotic crossing over

Carol M. Manhart et al.

DNA REPAIR (2016)

Article Obstetrics & Gynecology

Male adolescent fertility preservation

Jared L. Moss et al.

FERTILITY AND STERILITY (2016)

Review Oncology

Radiation oncology in the era of precision medicine

Michael Baumann et al.

NATURE REVIEWS CANCER (2016)

Article Oncology

Persistent DNA Damage in Spermatogonial Stem Cells After Fractionated Low-Dose Irradiation of Testicular Tissue

Angelika Grewenig et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2015)

Article Medicine, General & Internal

Long-term effects of radiation exposure on health

Kenji Kamiya et al.

LANCET (2015)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

Adelheid Soubry et al.

BIOESSAYS (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of testicular dose and associated risk from common pelvis radiation therapy in Iran

Ahmad Shanei et al.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2014)

Review Genetics & Heredity

Tissue specificity in DNA repair: lessons from trinucleotide repeat instability

Vincent Dion

TRENDS IN GENETICS (2014)

Article Multidisciplinary Sciences

Offspring production with sperm grown in vitro from cryopreserved testis tissues

Tetsuhiro Yokonishi et al.

NATURE COMMUNICATIONS (2014)

Article Obstetrics & Gynecology

Effects of chemotherapy and radiotherapy on spermatogenesis in humans

Marvin L. Meistrich

FERTILITY AND STERILITY (2013)

Article Cell Biology

Ku70 and non-homologous end joining protect testicular cells from DNA damage

Emad A. Ahmed et al.

JOURNAL OF CELL SCIENCE (2013)

Review Biotechnology & Applied Microbiology

Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents

Mark P. Little et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2013)

Review Biochemistry & Molecular Biology

Types, Causes, Detection and Repair of DNA Fragmentation in Animal and Human Sperm Cells

Clara Gonzalez-Marin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Oncology

Genetic Disease in the Children of Danish Survivors of Childhood and Adolescent Cancer

Jeanette F. Winther et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

Review Urology & Nephrology

Metabolic regulation is important for spermatogenesis

Luis Rato et al.

NATURE REVIEWS UROLOGY (2012)

Article Multidisciplinary Sciences

In vitro production of functional sperm in cultured neonatal mouse testes

Takuya Sato et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Chemistry and biology of reactive oxygen species in signaling or stress responses

Bryan C. Dickinson et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Oncology

TOLERANCE OF ARTERIES TO MICROPLANAR X-RAY BEAMS

Boudewijn van der Sanden et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)

Review Oncology

The Oncofertility Consortium-addressing fertility in young people with cancer

Teresa K. Woodruff

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Review Medicine, General & Internal

Current Concepts: Preservation of Fertility in Patients with Cancer.

Jacqueline S. Jeruss et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Oncology

Genetic variants and normal tissue toxicity after radiotherapy: A systematic review

Christian Nicolaj Andreassen et al.

RADIOTHERAPY AND ONCOLOGY (2009)

Article Pharmacology & Pharmacy

Evidence for a role of paternal exposures in developmental toxicity

Sylvaine Cordier

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2008)

Article Biology

Low levels of clustered oxidative DNA damage induced at low and high LET irradiation in mammalian cells

Didier Boucher et al.

RADIATION AND ENVIRONMENTAL BIOPHYSICS (2006)

Article Oncology

Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo

Igor Koturbash et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

Article Multidisciplinary Sciences

Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential

FA Dilmanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemistry & Molecular Biology

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis

EC Chao et al.

NUCLEIC ACIDS RESEARCH (2006)

Review Urology & Nephrology

Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach

A Agarwal et al.

BJU INTERNATIONAL (2005)

Review Cell Biology

Homologous recombinational repair proteins in mouse meiosis

LA Bannister et al.

CYTOGENETIC AND GENOME RESEARCH (2004)

Review Obstetrics & Gynecology

Role of caspases in male infertility

TM Said et al.

HUMAN REPRODUCTION UPDATE (2004)

Article Multidisciplinary Sciences

Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know

DJ Brenner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Reproductive Biology

DNA double-strand breaks and γ-H2AX signaling in the testis

G Hamer et al.

BIOLOGY OF REPRODUCTION (2003)

Article Multidisciplinary Sciences

Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice

R Barber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Genome stability - Transgenerational mutation by radiation

YE Dubrova et al.

NATURE (2000)

Article Oncology

Radiation carcinogenesis

JB Little

CARCINOGENESIS (2000)