4.6 Review

Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models

Related references

Note: Only part of the references are listed.
Article Oncology

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma

Ravikanth Maddipati et al.

Summary: This study investigated the biological and functional differences driving metastasis in patients with PDAC using a mouse model. The findings revealed an association between the extent of metastasis and gene amplification or transcriptional upregulation of the MYC gene and its downstream targets. Functional experiments demonstrated that MYC promotes metastasis by recruiting tumor-associated macrophages. Further analysis showed that metastatic progression in human PDAC is associated with activation of MYC signaling pathways and MYC amplifications in metastatic patients specifically.

CANCER DISCOVERY (2022)

Article Medicine, Research & Experimental

Krasmutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer

Kanchan Singh et al.

Summary: The study found that ectopic expression of oncogenic mutant K-Ras in pancreatic ducts generates early and late PanIN as well as PDAC, with evidence suggesting that AKT signaling is an important early driver of invasive ductal derived PDAC. This Ras rheostat model highlights the significance of elevated Kras mutation frequency and loss of PTEN in driving PanIN and invasive ductal derived PDAC.

LABORATORY INVESTIGATION (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Chemistry, Medicinal

Targeting MYC: From understanding its biology to drug discovery

Julie Ross et al.

Summary: The MYC oncogene is a high priority target for clinical intervention in cancer patients, with direct small molecule inhibition traditionally facing challenges due to its intrinsically disordered nature. However, recent strategies for indirectly targeting MYC, such as MYC guanine quadruplex stabilization and disruption of MYC:MAX heterodimer, have emerged with the advancement of protein structural information and computational tools in medicinal chemistry.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Gastroenterology & Hepatology

The pancreatic cancer genome revisited

Akimasa Hayashi et al.

Summary: Pancreatic cancer is a genetic disease characterized by recurrent genetic alterations. Major roles have been identified for genetic alterations in complex systems such as SWI/SNF and COMPASS, as well as copy number alterations in genes like GATA6 and MYC. Developments in germline variants, mismatch repair deficiencies, and homologous recombination deficiencies highlight the shift towards precision medicine in pancreatic cancer research.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Editorial Material Cell Biology

The 2019 WHO classification of tumours of the digestive system

Iris D. Nagtegaal et al.

HISTOPATHOLOGY (2020)

Article Genetics & Heredity

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

Michelle Chan-Seng-Yue et al.

NATURE GENETICS (2020)

Article Oncology

The Evolutionary Origins of Recurrent Pancreatic Cancer

Hitomi Sakamoto et al.

CANCER DISCOVERY (2020)

Article Oncology

NCCN: Continuing Education

Mary B. Daly et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Review Biochemistry & Molecular Biology

TGF-β Signaling

Kalliopi Tzavlaki et al.

BIOMOLECULES (2020)

Review Oncology

The biological basis and function ofGNASmutation in pseudomyxoma peritonei: a review

Yu-Lin Lin et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

Review Genetics & Heredity

Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies

Richard C. Centore et al.

TRENDS IN GENETICS (2020)

Review Oncology

UTX Mutations in Human Cancer

Lu Wang et al.

CANCER CELL (2019)

Article Multidisciplinary Sciences

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele

Jinghai Wu et al.

PLOS ONE (2017)

Article Multidisciplinary Sciences

ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer

Yiannis Drosos et al.

SCIENTIFIC REPORTS (2017)

Article Gastroenterology & Hepatology

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice

Paola Martinelli et al.

Article Cell Biology

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

Ozhan Ocal et al.

DISEASE MODELS & MECHANISMS (2015)

Article Multidisciplinary Sciences

Whole genomes redefine the mutational landscape of pancreatic cancer

Nicola Waddell et al.

NATURE (2015)

Article Multidisciplinary Sciences

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Agnieszka K. Witkiewicz et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality

Ravikanth Maddipati et al.

CANCER DISCOVERY (2015)

Article Endocrinology & Metabolism

GNAS Spectrum of Disorders

Serap Turan et al.

CURRENT OSTEOPOROSIS REPORTS (2015)

Article Cell Biology

A modular and flexible ESC-based mouse model of pancreatic cancer

Michael Saborowski et al.

GENES & DEVELOPMENT (2014)

Article Genetics & Heredity

RNF43 is frequently mutated in colorectal and endometrial cancers

Marios Giannakis et al.

NATURE GENETICS (2014)

Article Biochemistry & Molecular Biology

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Nina Schoenhuber et al.

NATURE MEDICINE (2014)

Review Biochemistry & Molecular Biology

PTEN function: the long and the short of it

Benjamin D. Hopkins et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Article Oncology

Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms

G. Nishikawa et al.

BRITISH JOURNAL OF CANCER (2013)

Article Biochemistry & Molecular Biology

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying et al.

Article Biochemistry & Molecular Biology

EMT and Dissemination Precede Pancreatic Tumor Formation

Andrew D. Rhim et al.

Article Multidisciplinary Sciences

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer

A. Hunter Shain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

Karen M. Mann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

Jian Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

Jian Wu et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Review Gastroenterology & Hepatology

High Cancer Risk in Peutz-Jeghers Syndrome: A Systematic Review and Surveillance Recommendations

M. G. F. van Lier et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

Review Endocrinology & Metabolism

Role of the GATA family of transcription factors in endocrine development, function, and disease

Robert S. Viger et al.

MOLECULAR ENDOCRINOLOGY (2008)

Review Cell Biology

LKB1 and AMPK in cell polarity and division

Tyisha Williams et al.

TRENDS IN CELL BIOLOGY (2008)

Article Gastroenterology & Hepatology

Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics

Noriyoshi Fukushima et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY (2007)

Review Oncology

TGFβ:: the molecular Jekyll and Hyde of cancer

Brian Bierie et al.

NATURE REVIEWS CANCER (2006)

Article Oncology

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome

Nicholas Hearle et al.

CLINICAL CANCER RESEARCH (2006)

Review Biochemistry & Molecular Biology

Back to the roots: the remarkable RAF oncogene story

A. Zebisch et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Review Biochemistry & Molecular Biology

TGF-β and epithelial-to-mesenchymal transitions

J Zavadil et al.

ONCOGENE (2005)

Article Multidisciplinary Sciences

High frequency of mutations of the PIK3CA gene in human cancers

Y Samuels et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Two related ARID family proteins are alternative subunits of human SWI/SNF complexes

XM Wang et al.

BIOCHEMICAL JOURNAL (2004)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)

Article Multidisciplinary Sciences

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

NE Sharpless et al.

NATURE (2001)

Article Multidisciplinary Sciences

Surfing the p53 network

B Vogelstein et al.

NATURE (2000)