Related references
Note: Only part of the references are listed.The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma
Alexander Ou et al.
CANCERS (2021)
In vitro biomimetic models for glioblastoma-a promising tool for drug response studies
Tijana Stankovic et al.
DRUG RESISTANCE UPDATES (2021)
Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models
Max A. Stockslager et al.
CELL REPORTS (2021)
A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma
Sakthi Lenin et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
In Vitro Glioblastoma Models: A Journey into the Third Dimension
Mayra Paolillo et al.
CANCERS (2021)
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
Chen He et al.
NATURE COMMUNICATIONS (2021)
Tumor-Associated Microglia and Macrophages in the Glioblastoma Microenvironment and Their Implications for Therapy
Rikke Sick Andersen et al.
CANCERS (2021)
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor-Glioma Therapy?
Ni Tong et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Treatment scheduling effects on the evolution of drug resistance in heterogeneous cancer cell populations
Gauri A. Patwardhan et al.
NPJ BREAST CANCER (2021)
Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review
Neha Singh et al.
CANCER DRUG RESISTANCE (2021)
Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma
Weikun Xiao et al.
MATRIX BIOLOGY (2020)
Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance
Julia C. Fontoura et al.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)
Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2020)
Small molecule tyrosine kinase inhibitors in glioblastoma
Gayoung Kim et al.
ARCHIVES OF PHARMACAL RESEARCH (2020)
Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
Katharina Rothe et al.
CELL STEM CELL (2020)
Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
Evan K. Day et al.
CELL REPORTS (2020)
Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy
Charles Pottier et al.
CANCERS (2020)
Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?
Paulo Linhares et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
The Possible Role of Cancer Stem Cells in the Resistance to Kinase Inhibitors of Advanced Thyroid Cancer
Fiorenza Giani et al.
CANCERS (2020)
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
Anna Golebiewska et al.
ACTA NEUROPATHOLOGICA (2020)
FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention
Antonella De Luca et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
RAF and MEK inhibitor therapy in adult patients with brain tumors: a case-based overview and practical management of adverse events
Karisa C. Schreck et al.
NEURO-ONCOLOGY PRACTICE (2020)
Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Caleb Jensen et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2020)
Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions
Viktorija Juric et al.
CANCER DRUG RESISTANCE (2020)
Glioblastoma Stem cells: Driving Resilience through Chaos
Briana C. Prager et al.
TRENDS IN CANCER (2020)
Challenges to curing primary brain tumours
Kenneth Aldape et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
Intratumoural Heterogeneity Underlies Distinct Therapy Responses and Treatment Resistance in Glioblastoma
Seckin Akgul et al.
CANCERS (2019)
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
Anne Dirkse et al.
NATURE COMMUNICATIONS (2019)
PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma
Shota Tanaka et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel et al.
CELL (2019)
MET in glioma: signaling pathways and targeted therapies
Fangling Cheng et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma
Dieter Henrik Heiland et al.
NATURE COMMUNICATIONS (2019)
Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
Ander Saenz-Antonanzas et al.
CANCERS (2019)
Oncogenic BRAF Alterations and Their Role in Brain Tumors
Felix Behling et al.
CANCERS (2019)
Fibroblast Growth Factor Receptor Functions in Glioblastoma
Ana Jimenez-Pascual et al.
CELLS (2019)
Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons
Prospero Civita et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
A view on drug resistance in cancer
Neil Vasan et al.
NATURE (2019)
Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma
Nichola Cruickshanks et al.
CLINICAL CANCER RESEARCH (2019)
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma
Brett W. Stringer et al.
SCIENTIFIC REPORTS (2019)
Drug resistance and combating drug resistance in cancer
Xuan Wang et al.
CANCER DRUG RESISTANCE (2019)
2D and 3D cell cultures - a comparison of different types of cancer cell cultures
Marta Kapalczynska et al.
ARCHIVES OF MEDICAL SCIENCE (2018)
PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation
Xin Yao Qiu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Kinase-targeted cancer therapies: progress, challenges and future directions
Khushwant S. Bhullar et al.
MOLECULAR CANCER (2018)
Reactive Astrocytes in Glioblastoma Multiforme
Xiudong Guan et al.
MOLECULAR NEUROBIOLOGY (2018)
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Zhenyi An et al.
ONCOGENE (2018)
Concise Review: Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer: The Role of Cancer Stem Cells
Marzia Del Re et al.
STEM CELLS (2018)
Insulin-like growth factor 1/insulin-like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells
Mingshi Zhang et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)
Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized therapy
Michele Patrizii et al.
FRONTIERS IN ONCOLOGY (2018)
A bidirectional crosstalk between glioblastoma and brain endothelial cells potentiates the angiogenic and proliferative signaling of sphingosine-1-phosphate in the glioblastoma microenvironment
Loubna Abdel Hadi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)
PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines
Estefania Carrasco-Garcia et al.
CELLS (2018)
Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence
Carmen Mecca et al.
DISEASE MARKERS (2018)
A Critical Overview of Targeted Therapies for Glioblastoma
Kewal K. Jain
FRONTIERS IN ONCOLOGY (2018)
Combination therapy to checkmate Glioblastoma: clinical challenges and advances
Debarati Ghosh et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2018)
Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma A Randomized Clinical Trial
Roger Stupp et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)
Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development
Hua-fu Zhao et al.
MOLECULAR CANCER (2017)
Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas
Damian A. Almiron Bonnin et al.
MOLECULAR CANCER THERAPEUTICS (2017)
Modeling Physiological Events in 2D vs. 3D Cell Culture
Kayla Duval et al.
PHYSIOLOGY (2017)
Analysis of Chemopredictive Assay for Targeting Cancer Stem Cells in Glioblastoma Patients
Candace M. Howard et al.
TRANSLATIONAL ONCOLOGY (2017)
The effects of PI3K-mediated signalling on glioblastoma cell behaviour
Julia Langhans et al.
ONCOGENESIS (2017)
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Ping Wee et al.
CANCERS (2017)
Targeting cellular pathways in glioblastoma multiforme
Joshua R. D. Pearson et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)
Glioma sensitive or chemoresistant to temozolomide differentially modulate macrophage protumor activities
Juliana H. Azarnbuja et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Qianghu Wang et al.
CANCER CELL (2017)
The Role of EGFR-Met Interactions in the Pathogenesis of Glioblastoma and Resistance to Treatment
Gao Guo et al.
CURRENT CANCER DRUG TARGETS (2017)
InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma
Yufang Ma et al.
CLINICAL CANCER RESEARCH (2016)
Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation
Shuli Xia et al.
NEURO-ONCOLOGY (2016)
Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
Sebastian Bender et al.
NATURE MEDICINE (2016)
Epidermal growth factor receptor targeting and challenges in glioblastoma
Amy Haseley Thorne et al.
NEURO-ONCOLOGY (2016)
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
Xiaoman Li et al.
ONCOTARGET (2016)
Culture on 3D Chitosan-Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells
Kui Wang et al.
ADVANCED HEALTHCARE MATERIALS (2016)
Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
Anna Segerman et al.
CELL REPORTS (2016)
Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy
Wanyin Chen et al.
STEM CELLS INTERNATIONAL (2016)
Hallmarks of glioblastoma: a systematic review
Dorte Schou Noroxe et al.
ESMO OPEN (2016)
Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein
Anna C. Navis et al.
ACTA NEUROPATHOLOGICA (2015)
IGF-IR: a new prognostic biomarker for human glioblastoma
C. Maris et al.
BRITISH JOURNAL OF CANCER (2015)
Ten things you should know about protein kinases: IUPHAR Review 14
Doriano Fabbro et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Spatiotemporal Evolution of the Primary Glioblastoma Genome
Jinkuk Kim et al.
CANCER CELL (2015)
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution
Hoon Kim et al.
GENOME RESEARCH (2015)
Targeting cancer with kinase inhibitors
Stefan Gross et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications
S. A. Greenall et al.
ONCOGENE (2015)
FDA-approved small-molecule kinase inhibitors
Peng Wu et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma
Tobias Kessler et al.
ONCOTARGET (2015)
Glioblastoma: Defining Tumor Niches
Dolores Hambardzumyan et al.
TRENDS IN CANCER (2015)
Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
Rasheena Edmondson et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2014)
Multi-drug resistance in cancer chemotherapeutics: Mechanisms and lab approaches
Qiong Wu et al.
CANCER LETTERS (2014)
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas
Zhao-Shi Bao et al.
GENOME RESEARCH (2014)
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma
Ning Yang et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2014)
Culture Dimensionality Influences the Resistance of Glioblastoma Stem-like Cells to Multikinase Inhibitors
Gonzalo Fernandez-Fuente et al.
MOLECULAR CANCER THERAPEUTICS (2014)
The role of cancer stem cells in glioblastoma
Swetha J. Sundar et al.
NEUROSURGICAL FOCUS (2014)
Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA
David A. Nathanson et al.
SCIENCE (2014)
Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
Brett E. Johnson et al.
SCIENCE (2014)
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Anoop P. Patel et al.
SCIENCE (2014)
Glioblastoma multiforme - an overview
Kaja Urbanska et al.
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY (2014)
Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature
Maria-del-Mar Inda et al.
CANCERS (2014)
Mechanisms of resistance to PDGFR inhibition in glioblastoma
Sandra Pastorino et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
PKC signaling in glioblastoma
Analia do Carmo et al.
CANCER BIOLOGY & THERAPY (2013)
The Somatic Genomic Landscape of Glioblastoma
Cameron W. Brennan et al.
CELL (2013)
Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
Mark R. Gilbert et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
The Clinical Relevance of Cancer Cell Lines
Jean-Pierre Gillet et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor
Chengshi Xu et al.
SCIENTIFIC WORLD JOURNAL (2013)
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Bryant England et al.
TUMOR BIOLOGY (2013)
Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide
D. Biasoli et al.
CELL DEATH & DISEASE (2013)
De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients
David Akhavan et al.
CANCER DISCOVERY (2013)
Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer
Alberto Bardelli et al.
CANCER DISCOVERY (2013)
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
Petra Hamerlik et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
A restricted cell population propagates glioblastoma growth after chemotherapy
Jian Chen et al.
NATURE (2012)
Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas
Agusti Alentorn et al.
NEURO-ONCOLOGY (2012)
Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme
H. J. Jun et al.
ONCOGENE (2012)
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
Nicholas J. Szerlip et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
Devendra Singh et al.
SCIENCE (2012)
Differential Sensitivity of Glioma-versus Lung Cancer-Specific EGFR Mutations to EGFR Kinase Inhibitors
Igor Vivanco et al.
CANCER DISCOVERY (2012)
Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide
Michael S. Bobola et al.
FRONTIERS IN ONCOLOGY (2012)
EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment
Gianmaria Liccardi et al.
CANCER RESEARCH (2011)
Targeting the AKT Pathway in Glioblastoma
Kelli A. McDowell et al.
CURRENT PHARMACEUTICAL DESIGN (2011)
Current Status of Methods to Assess Cancer Drug Resistance
Theodor H. Lippert et al.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2011)
A Review of VEGF/VEGFR-Targeted Therapeutics for Recurrent Glioblastoma
David A. Reardon et al.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2011)
Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Aleksandra Bielen et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Temozolomide: Mechanisms of Action, Repair and Resistance
Jihong Zhang et al.
Current Molecular Pharmacology (2011)
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G. W. Verhaak et al.
CANCER CELL (2010)
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9
Sasa Kenig et al.
CANCER LETTERS (2010)
Targeting Ras-RAF-ERK and its Interactive Pathways as a Novel Therapy for Malignant Gliomas
H. -W. Lo
CURRENT CANCER DRUG TARGETS (2010)
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
Tatsuya Ozawa et al.
GENES & DEVELOPMENT (2010)
Kinase mutations in human disease: interpreting genotype-phenotype relationships
Piya Lahiry et al.
NATURE REVIEWS GENETICS (2010)
O-6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients
Sabine Spiegl-Kreinecker et al.
NEURO-ONCOLOGY (2010)
Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies
Philip C. De Witt Hamer
NEURO-ONCOLOGY (2010)
MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
F. Cappuzzo et al.
ANNALS OF ONCOLOGY (2009)
Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1
Chris Folkins et al.
CANCER RESEARCH (2009)
Nuclear Translocation of the Epidermal Growth Factor Receptor Family Membrane Tyrosine Kinase Receptors
Shao-Chun Wang et al.
CLINICAL CANCER RESEARCH (2009)
STAT3 Regulation of Glioblastoma Pathogenesis
Nuria la Iglesia et al.
CURRENT MOLECULAR MEDICINE (2009)
EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
Bachchu Lal et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts
Gaspar J. Kitange et al.
NEURO-ONCOLOGY (2009)
Angiogenesis as a Therapeutic Target in Malignant Gliomas
Andrew S. Chi et al.
ONCOLOGIST (2009)
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang et al.
NATURE REVIEWS CANCER (2009)
EGFR Inhibition in the Treatment of Non-Small Cell Lung Cancer
David E. Gerber
DRUG DEVELOPMENT RESEARCH (2008)
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival
Angus J. Cameron et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
Emily C. Brantley et al.
MOLECULAR CANCER RESEARCH (2008)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L. Chin et al.
NATURE (2008)
Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells
Mia Carapancea et al.
JOURNAL OF NEURO-ONCOLOGY (2007)
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
Jayne M. Stommel et al.
SCIENCE (2007)
MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
Bernd Kaina et al.
DNA REPAIR (2007)
RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations
Judith Jeuken et al.
ACTA NEUROPATHOLOGICA (2007)
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
Paul H. Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors
Ingo K. Mellinghoff et al.
CLINICAL CANCER RESEARCH (2007)
Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
Brian P. Rubin et al.
LABORATORY INVESTIGATION (2006)
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
Shideng Bao et al.
CANCER RESEARCH (2006)
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman et al.
NATURE REVIEWS GENETICS (2006)
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma
Christopher E. Pelloski et al.
CLINICAL CANCER RESEARCH (2006)
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
IK Mellinghoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Activating mutations in c-KIT and PDGFRα are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes
H Burger et al.
CANCER BIOLOGY & THERAPY (2005)
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
R Abounader et al.
NEURO-ONCOLOGY (2005)
The protein kinase Cβ-selective inhibitor, enzastaurin (LY317615.HCI), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
JR Graff et al.
CANCER RESEARCH (2005)
PIK3CA mutations in glioblastoma multiforme
C Hartmann et al.
ACTA NEUROPATHOLOGICA (2005)
EGFR tyrosine kinase domain mutations in human gliomas
Y Marie et al.
NEUROLOGY (2005)
The p53 pathway: positive and negative feedback loops
SL Harris et al.
ONCOGENE (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II
JL Boerner et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas
CB Knobbe et al.
ACTA NEUROPATHOLOGICA (2004)
Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas
M Mizoguchi et al.
BRAIN PATHOLOGY (2004)
Human brain tumor-derived PDGFR-α deletion mutant is transforming
ID Clarke et al.
ONCOGENE (2003)
Expression of extracellular matrix components in a highly infiltrative in vivo glioma model
R Mahesparan et al.
ACTA NEUROPATHOLOGICA (2003)
Protein kinases - the major drug targets of the twenty-first century?
P Cohen
NATURE REVIEWS DRUG DISCOVERY (2002)
The Rb/E2F pathway and cancer
JR Nevins
HUMAN MOLECULAR GENETICS (2001)
Angiogenesis in cancer and other diseases
P Carmeliet et al.
NATURE (2000)
Share Paper
