4.6 Article

The FHP01 DDX3X Helicase Inhibitor Exerts Potent Anti-Tumor Activity In Vivo in Breast Cancer Pre-Clinical Models

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

DDX3X: structure, physiologic functions and cancer

Jie Mo et al.

Summary: DDX3X, a member of the DEAD-box helicase family, plays critical roles in various stages of RNA metabolism and is implicated in the progression of diseases, especially cancer. Research has gradually unveiled the diverse functions of DDX3X in cancer biology, providing insights into its involvement in tumorigenesis and progression.

MOLECULAR CANCER (2021)

Review Oncology

Precision medicine in breast cancer: From clinical trials to clinical practice

Edoardo Crimini et al.

Summary: This review presents the most important molecular targets in breast cancer, classified according to their pathway and in accordance with ESCAT, assisting clinicians in making therapeutic decisions.

CANCER TREATMENT REVIEWS (2021)

Article Cell Biology

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

Deanna M. Patmore et al.

DEVELOPMENTAL CELL (2020)

Article Multidisciplinary Sciences

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

He Song et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

The prognostic effect of DDX3 upregulation in distant breast cancer metastases

Marise R. Heerma van Voss et al.

CLINICAL & EXPERIMENTAL METASTASIS (2017)

Review Biochemistry & Molecular Biology

Targeting RNA helicases in cancer: The translation trap

Marise R. Heerma van Voss et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse et al.

Article Multidisciplinary Sciences

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

Annalaura Brai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

Tsung-Ying He et al.

SCIENTIFIC REPORTS (2016)

Article Medicine, Research & Experimental

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

Guus M. Bol et al.

EMBO MOLECULAR MEDICINE (2015)

Article Biochemistry & Molecular Biology

Disulfide Bond Requirements for Active Wnt Ligands

Bryan T. MacDonald et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

DEAD box RNA helicase functions in cancer

Frances V. Fuller-Pace

RNA BIOLOGY (2013)

Article Multidisciplinary Sciences

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt-β-Catenin Signaling

Cristina-Maria Cruciat et al.

SCIENCE (2013)

Review Oncology

Choosing the right cell line for breast cancer research

Deborah L. Holliday et al.

BREAST CANCER RESEARCH (2011)

Review Biochemistry & Molecular Biology

DEAD-box helicases: Posttranslational regulation and function

Eric A. Gustafson et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Multidisciplinary Sciences

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

Chung-Sheng Lee et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Biochemistry & Molecular Biology

Oncogenic role of DDX3 in breast cancer biogenesis

M. Botlagunta et al.

ONCOGENE (2008)

Article Biochemistry & Molecular Biology

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements

MT Veeman et al.

CURRENT BIOLOGY (2003)