4.7 Review

Rituximab Therapy for Adults with Nephrotic Syndromes: Standard Schedules or B Cell-Targeted Therapy?

Related references

Note: Only part of the references are listed.
Article Rheumatology

Disparity in peripheral and renal B-cell depletion with rituximab in systemic lupus erythematosus: an opportunity for obinutuzumab?

Venkat R. Reddy et al.

Summary: This study investigated the factors contributing to the variability of rituximab-mediated B cell depletion (BCD) in systemic lupus erythematosus (SLE). The results showed that BCD was less efficient in SLE compared to rheumatoid arthritis (RA). B cells were detectable in renal biopsy samples of SLE patients who had a poor response to rituximab. No significant relationships were found between peripheral BCD and patient demographics or B cell surface protein expression. Obinutuzumab was more efficient than rituximab at inducing BCD.

RHEUMATOLOGY (2022)

Review Transplantation

The evolution of the therapeutic approach to membranous nephropathy

Claudio Ponticelli et al.

Summary: Primary membranous nephropathy (MN) is a common cause of nephrotic syndrome (NS) in adults, with various treatment options including glucocorticoids, alkylating agents, calcineurin inhibitors, and rituximab. Results from randomized trials and observational studies show conflicting outcomes.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

Article Medical Laboratory Technology

The ISCCA flow protocol for the monitoring of anti-CD20 therapies in autoimmune disorders

Arianna Gatti et al.

Summary: The research discusses the use of a standardized immune monitoring protocol for anti-CD20 therapies in autoimmune diseases, aiming to carefully monitor B cell levels to guide clinical decisions and ensure the safety and rational usage of treatment.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2021)

Article Urology & Nephrology

Efficacy of low or standard rituximab-based protocols and comparison to Ponticelli's regimen in membranous nephropathy

Roberta Fenoglio et al.

Summary: The study compared the efficacy and safety of low-dose RTX, standard RTX, and Ponticelli's regimen in patients with primary MN, finding that RTX, even at low doses, is a promising alternative option.

JOURNAL OF NEPHROLOGY (2021)

Article Urology & Nephrology

Retrospective single-arm cohort study of steroid-dependent minimal change nephrotic syndrome treated with very low-dose rituximab

Keiji Fujimoto et al.

Summary: The study found that low-dose RTX therapy is effective in maintaining remission, reducing prednisolone and cyclosporine doses in patients with steroid-dependent MCNS. Furthermore, it was observed that peripheral CD19-positive cell count remained unchanged in the majority of cases even after achieving complete remission.

CLINICAL NEPHROLOGY (2021)

Article Urology & Nephrology

Rituximab for the management of idiopathic membranous nephropathy: a meta-analysis

Lan Huang et al.

Summary: Rituximab therapy in IMN patients can provide approximately 67% remission rate. The reduction in proteinuria was greater in patients who had higher baseline proteinuria.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)

Article Urology & Nephrology

Successful treatment of PLA2R1-antibody positive membranous nephropathy with ocrelizumab

Tilman Schmidt et al.

Summary: Membranous nephropathy (MN) is commonly caused by antibodies targeting podocyte protein phospholipase A(2)receptor 1 (PLA(2)R1). While rituximab is often effective for treatment of MN, a significant portion of patients do not respond to it, necessitating the search for alternative treatment options. Ocrelizumab, a humanized B cell depleting antibody, may be an efficacious alternative treatment for patients with MN who fail to achieve remission or are immunologically sensitized to rituximab.

JOURNAL OF NEPHROLOGY (2021)

Review Urology & Nephrology

Membranous nephropathy: current understanding of various causes in light of new target antigens

Pierre Ronco et al.

Summary: Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. Recent advancements in technology have led to the discovery of new antigens and biomarkers associated with the disease, which may result in a new classification system based on serology and tissue antigen identification. The identification of these antigens also has significant implications for patient care, as they provide valuable markers for treatment monitoring and etiological investigations.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2021)

Article Urology & Nephrology

Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases

Brad H. Rovin et al.

Summary: This article provides an overview of the latest clinical practice guidelines for the management of glomerular diseases, aimed at assisting clinicians worldwide caring for patients with glomerulonephritis. The guidelines cover various glomerular diseases, offering guidance on diagnosis, prognosis, treatment, and special situations, as well as useful infographics and research recommendations.

KIDNEY INTERNATIONAL (2021)

Editorial Material Transplantation

Rituximab in primary membranous nephropathy: a comparative study of three dosing regimens

Raja Ramachandran et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

Article Urology & Nephrology

The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy

Gema Fernandez-Juarez et al.

Summary: The study found that a cyclical corticosteroid-cyclophosphamide regimen was more effective in inducing persistent remission in patients with primary membranous nephropathy compared to sequential therapy with tacrolimus and rituximab, with a higher rate of complete remission. Overall, treatment with corticosteroid-cyclophosphamide resulted in a significantly greater number of patients achieving remission.

KIDNEY INTERNATIONAL (2021)

Article Cell Biology

Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia

Etienne Crickx et al.

Summary: The study identifies specific characteristics of memory B cells that escape RTX-mediated depletion and reactivate upon RTX clearance. These RTX-resistant autoreactive memory B cells give rise to plasma cells and further germinal center reactions, being efficient targets for anti-CD19 therapies.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Immunology

Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways

Alexander Stewart et al.

Summary: The separation of B cells into different subsets has provided insights into their diverse functions in immune responses. Advances in single-cell techniques have enabled a deeper understanding of B cell characteristics and functions, though challenges remain. This study offers a reference single-cell dataset for better classification of functional B cell subsets in peripheral blood, highlighting the complexity and diversity of B cell populations.

FRONTIERS IN IMMUNOLOGY (2021)

Article Urology & Nephrology

Human or Chimeric Monoclonal Anti-CD20 Antibodies for Children with Nephrotic Syndrome: A Superiority Randomized Trial

Pietro Ravani et al.

Summary: In children with nephrotic syndrome maintained in remission with prednisone and calcineurin inhibitors, a single dose of ofatumumab was not superior to a single dose of rituximab in preventing relapse at 1 year or 24 months. B cell subpopulation reconstitution and adverse events were comparable between the two groups.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Review Pediatrics

Rituximab therapy for refractory steroid-resistant nephrotic syndrome in children

Koichi Kamei et al.

PEDIATRIC NEPHROLOGY (2020)

Article Multidisciplinary Sciences

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Lionel Rouge et al.

SCIENCE (2020)

Article Urology & Nephrology

Rituximab in maintaining remission in adults with podocytopathy

Raja Ramachandran et al.

NEPHROLOGY (2020)

Article Medicine, General & Internal

Personalized Medicine for PLA2R1-Related Membranous Nephropathy: A Multicenter Randomized Control Trial

Vesna Brglez et al.

FRONTIERS IN MEDICINE (2020)

Article Multidisciplinary Sciences

B cells reappear less mature and more activated after their anti-CD20-mediated depletion in multiple sclerosis

Nitzan Nissimov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Urology & Nephrology

Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy

Gian Marco Ghiggeri et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Review Medicine, General & Internal

Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association

Manuel Alfredo Podesta et al.

FRONTIERS IN MEDICINE (2020)

Article Urology & Nephrology

Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study

Takayuki Katsuno et al.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2019)

Letter Transplantation

Rituximab bioavailability in primary membranous nephropathy

Sonia Boyer-Suavet et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2019)

Article Urology & Nephrology

High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy

Barbara Seitz-Polski et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Medicine, General & Internal

Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy

F. C. Fervenza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Pharmacology & Pharmacy

Rituximab Exhibits Altered Pharmacokinetics in Patients With Membranous Nephropathy

Uma Fogueri et al.

ANNALS OF PHARMACOTHERAPY (2019)

Article Urology & Nephrology

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy

Barbara Seitz-Polski et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Transplantation

Rituximab for non-responsive idiopathic membranous nephropathy in a Chinese cohort

Xin Wang et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)

Review Urology & Nephrology

Differentiating Primary, Genetic, and Secondary FSGS in Adults: A Clinicopathologic Approach

An S. De Vriese et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Medicine, General & Internal

Rituximab and Fibrillary Glomerulonephritis: Interest of B Cell Reconstitution Monitoring

Claire Leibler et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Review Clinical Neurology

Ocrelizumab: a new milestone in multiple sclerosis therapy

Patricia Mulero et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2018)

Article Urology & Nephrology

Relapse of nephrotic syndrome during post-rituximab peripheral blood B-lymphocyte depletion

Mai Sato et al.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2018)

Review Urology & Nephrology

Rituximab for nephrotic syndrome in children

Kazumoto Iijima et al.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2017)

Article Urology & Nephrology

Rituximab for Severe Membranous Nephropathy: A 6-Month Trial with Extended Follow-Up

Karine Dahan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Biochemical Research Methods

Detection and quantification of rituximab in the human urine

Roland Jacobs et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2017)

Article Urology & Nephrology

High-Dose Rituximab Ineffective for Focal Segmental Glomerulosclerosis: A Long-Term Observation Study

Dario Roccatello et al.

AMERICAN JOURNAL OF NEPHROLOGY (2017)

Article Hematology

Obinutuzumab: what is there to learn from clinical trials?

Guillaume Cartron et al.

BLOOD (2017)

Article Urology & Nephrology

B Cells, Antibodies, and More

William Hoffman et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

B Cell Reconstitution after Rituximab Treatment in Idiopathic Nephrotic Syndrome

Manuela Colucci et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

Minimal change disease and idiopathic FSGS: manifestations of the same disease

Rutger J. Maas et al.

NATURE REVIEWS NEPHROLOGY (2016)

Article Urology & Nephrology

Anti-Phospholipase A2 Receptor Antibody Titer Predicts Post-Rituximab Outcome of Membranous Nephropathy

Piero Ruggenenti et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Article Urology & Nephrology

Rituximab in Children with Steroid-Dependent Nephrotic Syndrome: A Multicenter, Open-Label, Noninferiority, Randomized Controlled Trial

Pietro Ravani et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Article Transplantation

Efficacy and safety of rituximab in children with difficult-to-treat nephrotic syndrome

Aditi Sinha et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)

Article Urology & Nephrology

Rituximab Treatment Prevents the Early Development of Proteinuria following Pig-to-Baboon Xeno-Kidney Transplantation

Masayuki Tasaki et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Urology & Nephrology

Rituximab in Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome

Piero Ruggenenti et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Urology & Nephrology

Phospholipase A2 Receptor Autoantibodies and Clinical Outcome in Patients with Primary Membranous Nephropathy

Elion Hoxha et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Medicine, General & Internal

Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

Nicola M. Tomas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Letter Medicine, General & Internal

Ofatumumab for Rituximab- Resistant Nephrotic Syndrome

Biswanath Basu

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Medicine, Research & Experimental

Rituximab in immunologic glomerular diseases

A. Ahsan Ejaz et al.

Article Transplantation

Rituximab in steroid-dependent idiopathic nephrotic syndrome in childhood-follow-up after CD19 recovery

Anne-Laure Sellier-Leclerc et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)

Article Transplantation

Long-term follow-up after rituximab for steroid-dependent idiopathic nephrotic syndrome

Markus J. Kemper et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)

Article Urology & Nephrology

Short-Term Effects of Rituximab in Children with Steroid- and Calcineurin-Dependent Nephrotic Syndrome: A Randomized Controlled Trial

Pietro Ravani et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Urology & Nephrology

Anti-Phospholipase A2 Receptor Antibodies Correlate with Clinical Status in Idiopathic Membranous Nephropathy

Julia M. Hofstra et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Review Rheumatology

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

Falk Hiepe et al.

NATURE REVIEWS RHEUMATOLOGY (2011)

Article Cell Biology

Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis

Alessia Fornoni et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Urology & Nephrology

Rituximab Therapy in Idiopathic Membranous Nephropathy: A 2-Year Study

Fernando C. Fervenza et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Pediatrics

Rituximab in refractory nephrotic syndrome

Agnieszka Prytula et al.

PEDIATRIC NEPHROLOGY (2010)

Article Hematology

Rituximab: Mechanism of Action

George J. Weiner

SEMINARS IN HEMATOLOGY (2010)

Article Hematology

CD20 as a Target for Therapeutic Type I and II Monoclonal Antibodies

Stephen A. Beers et al.

SEMINARS IN HEMATOLOGY (2010)

Article Urology & Nephrology

Rituximab Treatment of Adult Patients with Steroid-Resistant Focal Segmental Glomerulosclerosis

Gema Fernandez-Fresnedo et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Immunology

Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

Wojciech Wojciechowski et al.

IMMUNITY (2009)

Article Medicine, General & Internal

M-Type Phospholipase A(sub 2) Receptor as Target Antigen in Idiopathic Membranous Nephropathy.

Laurence H. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Urology & Nephrology

Titrating rituximab to circulating B cells to optimize lymphocytolytic therapy in idiopathic membranous nephropathy

Paolo Cravedi et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

Article Urology & Nephrology

Rituximab for idiopathic membranous nephropathy: Who can benefit?

Piero Ruggenenti et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

Article Hematology

Complement activation plays a key role in the side-effects of rituximab treatment

LE van der Kolk et al.

BRITISH JOURNAL OF HAEMATOLOGY (2001)