Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jcm11030720
Keywords
immunotherapy; targeted therapy; chemotherapy; salivary gland cancer; adenoid cystic carcinoma; salivary duct carcinoma; mucoepidermoid carcinoma; acinic cell carcinoma
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Surgical resection is the preferred treatment for salivary gland cancer. For inoperable and metastatic disease, various systemic therapies are available. However, there is a need for more research and molecular analysis to improve treatment outcomes.
Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical resection should be favored in resectable locoregional recurrent disease as well, and even the complete resection of all distant oligometastases has clinical benefit for the patients. For inoperable and disseminated metastatic disease, a multitude of systemic therapies including chemotherapy, targeted therapy, and immunotherapy are available. In this review, the current therapeutic options for inoperable recurrent or metastatic SGCs are summarized. Systemic treatment can achieve prolonged progression-free and overall survival, while the overall prognosis remains poor. Current clinical trials include only a limited number of patients and mostly combine different histologic subtypes. Additionally, no randomized controlled trial comparing different therapeutic options has been performed. In the future, further studies with a larger patient cohort and ideally only one histologic subtype are needed in order to improve the outcome for SGC patients. However, this may be difficult to accomplish due to the rarity and diversity of the disease. Additionally, molecular analyses need to be performed routinely in order to individualize treatment and to go one step further towards precision medicine.
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