Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/jcm10215077
Keywords
ME/CFS; dysbiosis; therapy; diagnosis; intestinal permeability; metabolic endotoxemia; LPS
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Common symptoms of ME/CFS include pain, cognitive dysfunction, and fatigue, with gastrointestinal problems also frequently reported. Research has shown significant alterations in the gut microbiota of ME/CFS patients, which may contribute to worsening symptoms.
The well-known symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic pain, cognitive dysfunction, post-exertional malaise and severe fatigue. Another class of symptoms commonly reported in the context of ME/CFS are gastrointestinal (GI) problems. These may occur due to comorbidities such as Crohn's disease or irritable bowel syndrome (IBS), or as a symptom of ME/CFS itself due to an interruption of the complex interplay between the gut microbiota (GM) and the host GI tract. An altered composition and overall decrease in diversity of GM has been observed in ME/CFS cases compared to controls. In this review, we reflect on genetics, infections, and other influences that may factor into the alterations seen in the GM of ME/CFS individuals, we discuss consequences arising from these changes, and we contemplate the therapeutic potential of treating the gut to alleviate ME/CFS symptoms holistically.
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