Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/jcm10215091
Keywords
trimethylamine N-oxide; cardiovascular disease; obesity; bariatric surgery; diabetes mellitus
Categories
Funding
- Korean Health Technology RD Project
- Ministry of Health &Welfare, Republic of Korea
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education
Ask authors/readers for more resources
The gut microbe-dependent metabolite TMAO has been linked to cardiovascular events in obese individuals, especially those with type 2 diabetes. A study conducted on Korean obese patients who underwent bariatric surgery found that TMAO levels increased in patients with T2DM after RYGB surgery, while choline levels decreased in all patients after RYGB. Further research is needed to understand the relationship between TMAO levels and bariatric surgery outcomes.
Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite, has been implicated as a novel risk factor for cardiovascular events related to obesity and type 2 diabetes mellitus (T2DM). The aim of the study was to test the hypothesis if TMAO is associated with the reduction of cardiovascular disease in the Korean obese patients who underwent bariatric surgery. From a subgroup of a multicenter, nonrandomized, controlled trial, titled KOBESS, 38 obese patients, 18 with and 20 without T2DM, who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were investigated. Bariatric surgery is indicated for Korean patients with a body mass index (BMI) >= 35 kg/m(2) or for Korean patients with a BMI >= 30 kg/m(2) who have comorbidities. Serum levels of TMAO and its precursors, betaine, carnitine, and choline were measured before and six months after bariatric surgery. The levels of TMAO and its precursors did not differ between obese patients with T2DM and non-T2DM at baseline. However, TMAO increased more than twofold in patients with T2DM after RYGB surgery, but not in patients without T2DM. Choline levels were decreased by half in all patients after RYGB. In patients with T2DM who underwent SG, TMAO, betaine, and carnitine levels did not change after the surgery. Furthermore, in obese patients who underwent bariatric surgery, increased TMAO levels were associated with both T2DM and RYGB, while reduced choline levels were associated with RYGB. These associations need to be further elucidated in follow-up studies to gain further insights into the relationship between TMAO levels and bariatric surgery outcomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available