Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/jcm11020422
Keywords
pulmonary embolism; therapeutic anticoagulation; recurrence pattern; glioblastoma survival
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Funding
- Novartis Foundation
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Therapeutic anticoagulation has a significant impact on the recurrence pattern in GBM patients, leading to an increase in multifocal, midline crossing, and sharp demarcated recurrence patterns. The underlying pathophysiology remains to be elucidated.
Background: Glioblastoma (GBM) patients are at particularly high risk for thrombotic complications. In the event of a postoperative pulmonary embolism, therapeutic anticoagulation (tAC) is indispensable. The impact of therapeutic anticoagulation on recurrence pattern in GBM is currently unknown. Methods: We conducted a matched-pair cohort analysis of 57 GBM patients with or without tAC that were matched for age, sex, gross total resection and MGMT methylation status in a ratio of 1:2. Patients' characteristics and clinical course were evaluated using medical charts. MRI characteristics were evaluated by two independent authors blinded to the AC status. Results: The morphologic MRI appearance in first GBM recurrence showed a significantly higher presence of multifocal, midline crossing and sharp demarcated GBM recurrence patterns in patients with therapeutic tAC compared to the matched control group. Although statistically non-significant, the therapeutic tAC cohort showed increased survival. Conclusion: Therapeutic anticoagulation induced significant morphologic changes in GBM recurrences. The underlying pathophysiology is discussed in this article but remains to be further elucidated.
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