Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jcm11030617
Keywords
breast cancer; breast cancer treatment; post-mastectomy pain syndrome; functional MRI; connectome; default mode network
Categories
Funding
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-901]
- DFG
Ask authors/readers for more resources
Neurological and psychiatric disorders are commonly observed in breast cancer survivors, leading to changes in the functional connectivity of the default mode network. This study used rs-fMRI to assess these changes and found significant differences in the functional connectivity compared to a control group. These alterations were associated with decreased quality of life in the patients.
Different neurological and psychiatric disorders such as vertebrobasilar insufficiency, chronic pain syndrome, anxiety, and depression are observed in more than 90% of patients after treatment for breast cancer and may cause alterations in the functional connectivity of the default mode network. The purpose of the present study is to assess changes in the functional connectivity of the default mode network in patients after breast cancer treatment using resting state functional magnetic resonance imaging (rs-fMRI). Rs-fMRI was performed using a 3.0T MR-scanner on patients (N = 46, women) with neurological disorders (chronic pain, dizziness, headaches, and/or tinnitus) in the late postoperative period (>12 months) after Patey radical mastectomy for breast cancer. According to the intergroup statistical analysis, there were differences in the functional connectivity of the default mode network in all 46 patients after breast cancer treatment compared to the control group (p < 0.01). The use of rs-fMRI in in breast cancer survivors allowed us to identify changes in the functional connectivity in the brain caused by neurological disorders, which correlated with a decreased quality of life in these patients. The results indicate the necessity to improve treatment and rehabilitation methods in this group of patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available