Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jcm11030820
Keywords
complement system proteins; IgA nephropathy; membrane attack complex; prognostic marker; urinary C5b-9
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Funding
- National Research Foundation of Korea (NRF) and Ministry of Science and ICT (MSIT) [NRF-2019R1G1A1098731]
- Soonchunhyang University Research Fund
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In this study, the potential of urinary C5b-9 as a prognostic biomarker for IgAN was evaluated. The results showed a positive correlation between baseline urinary C5b-9 levels and proteinuria, as well as a correlation between changes in urinary C5b-9 levels and changes in proteinuria and eGFR after treatment. However, baseline urinary C5b-9 levels were not a significant independent factor for predicting treatment response.
C5b-9 plays an important role in the pathogenesis of immunoglobin A nephropathy (IgAN). We evaluated C5b-9 as a prognostic marker for IgAN. We prospectively enrolled 33 patients with biopsy-proven IgAN. We analyzed the correlation between baseline urinary C5b-9 levels, posttreatment changes in their levels, and clinical outcomes, including changes in proteinuria, estimated glomerular filtration rate (eGFR), and treatment response. Baseline urinary C5b-9 levels were positively correlated with proteinuria (r = 0.548, p = 0.001) at the time of diagnosis. Changes in urinary C5b-9 levels were positively correlated with changes in proteinuria (r = 0.644, p < 0.001) and inversely correlated with changes in eGFR (r = -0.410, p = 0.018) at 6 months after treatment. Changes in urinary C5b-9 levels were positively correlated with time-averaged proteinuria during the follow-up period (r = 0.461, p = 0.007) but were not correlated with the mean annual rate of eGFR decline (r = -0.282, p = 0.112). Baseline urinary C5b-9 levels were not a significant independent factor that could predict the treatment response in logistic regression analyses (odds ratio 0.997; 95% confidence interval, 0.993 to 1.000; p = 0.078). Currently, urinary C5b-9 is not a promising prognostic biomarker for IgAN, and further studies are needed.
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