Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jcm11030530
Keywords
colonic diverticulosis; histology; segmental colitis associated to diverticulosis; interdiverticular inflammation
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The prevalence of segmental colitis associated with diverticulosis (SCAD) remains debated in patients with colonic diverticulosis, with suspected SCAD patients showing significantly lower age. The diagnosis of SCAD poses a challenge in clinical practice due to the heterogeneity of endoscopic findings and lack of stated histological criteria.
In patients with colonic diverticulosis, the prevalence of segmental colitis associated with diverticulosis (SCAD) is debated. The aim of this study was to assess the prevalence of SCAD in consecutive patients with diverticulosis in a single tertiary center. Over a six-month period, consecutive adult patients with colonic diverticulosis were included. Patients with endoscopic signs of interdiverticular mucosal inflammation (erythema, friability, and ulcerations) were considered suspected SCAD and underwent multiple biopsy samplings to confirm diagnosis. Clinical features were collected from diverticulosis and suspected SCAD patients. In total, 367 (26.5%) of 1383 patients who underwent colonoscopy presented diverticulosis. Among diverticulosis patients, 4.3% (n = 16) presented macroscopic signs of interdiverticular mucosal inflammation and were identified as suspected SCAD. Compared to that of patients with diverticulosis, the age of suspected SCAD patients was significantly lower (60 +/- 12.9 years (41.0-86.0) vs. 70 +/- 10.6 years (38.0-93.0)) (p = 0.047). Among patients with suspected SCAD, one patient received a new diagnosis of Crohn's disease, one had spirochetosis infection, and one presented drug-induced colitis. The remaining patients with suspected SCAD (n = 13) were not confirmed by histology. This observational study suggests that SCAD diagnosis is a challenge in clinical practice due to the heterogeneity of endoscopic findings and lack of stated histological criteria.
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