Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/jcm10225278
Keywords
acute myocardial infarction; serum lactate; percutaneous coronary intervention; magnetic resonance imaging
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This study found a correlation between high serum lactate levels and larger myocardial infarct size in patients with AMI. This indicates that high serum lactate is a predictive factor for advanced myocardial injury in AMI patients undergoing PCI.
Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR). Of these, 119 patients had serum lactate levels > 2.5 mmol/L on admission (high serum lactate group), whereas 241 patients had serum lactate levels & LE; 2.5 mmol/L (low serum lactate group). We compared the myocardial infarct size assessed by CMR between the two groups and performed inverse probability of treatment weighting (IPTW). In CMR analysis, myocardial infarct size was significantly greater in the high serum lactate group than in the low serum lactate group (22.0 & PLUSMN; 11.4% in the high serum lactate group vs. 18.9 & PLUSMN; 10.5% in the low serum lactate group; p = 0.011). The result was consistent after IPTW adjustment (21.5 & PLUSMN; 11.1% vs. 19.2 & PLUSMN; 10.4%; p = 0.044). In multivariate analysis, high serum lactate was associated with larger myocardial infarct (odds ratio 1.59; 95% confidence interval 1.00-2.51; p = 0.048). High serum lactate could predict advanced myocardial injury in AMI patients undergoing PCI.
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