Optic Disc Hemorrhage Is Not Associated with Global Choroidal Vessel Loss, but Is Associated with Localized Choroidal Vessel Loss in Glaucoma

Purpose: To investigate the relationship between optic disc hemorrhage (ODH) and the geographic pattern (regional vs. global) of parapapillary choroidal vessel density (pCVD) loss within the beta-parapapillary atrophy (beta-PPA) in open-angle glaucoma (OAG) Methods: This retrospective cross-sectional study included 100 OAG eyes with visual field (VF) defects confined to a single hemifield (50 with and 50 without ODH, matched for age (<= 10 years) and VF severity (<= 1 decibel) at the same hemifield), as well as 50 healthy eyes. The pCVD was measured using optical coherence tomography angiography (OCTA). The relationships between pCVD and clinical factors were assessed globally and regionally. Logistic regression analyses were performed to determine the clinical factors associated with the presence of ODH. Results: The pCVD values within ODH-affected hemiretinae of ODH+ eyes were significantly lower than those in the matched hemiretinae of ODH- eyes (p = 0.001). The presence of ODH was significantly correlated with a lower pCVD within ODH-dominant inferior hemiretinae (p < 0.05). Lower pCVD values at ODH-affected hemiretinae was significantly associated with the presence of ODH (p < 0.05). Conclusions: OAG eyes with ODH demonstrate a greater severity of regional pCVD loss at the hemiretinae spatially corresponding to the ODH location compared to OAG eyes without ODH.

Automated summary

The purpose of this study was to investigate the relationship between optic disc hemorrhage (ODH) and the loss of parapapillary choroidal vessel density (pCVD) in open-angle glaucoma (OAG). It was found that OAG eyes with ODH had a greater severity of regional pCVD loss at the corresponding locations compared to OAG eyes without ODH.