Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/jcm10204726
Keywords
postmortem micro-CT; virtual autopsy; fetal heart; congenital heart disease
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Micro-computed tomography (CT) is an effective non-invasive alternative for evaluating human fetal cardiac anatomy, especially in cases of early termination of pregnancy. It shows high diagnostic accuracy and allows for multiple off-time evaluations, making it a valuable tool for educational and research purposes in the fields of biology and bioengineering.
Micro-computed tomography (CT) is a non-invasive alternative to conventional macroscopic dissection for the evaluation of human fetal cardiac anatomy. This paper aims to systematically review the literature regarding the use of micro-CT to examine human fetal hearts, to illustrate its educational and research implications and to explain its possible directions for the future. A systematic literature review was conducted following the PRISMA statement to identify publications concerning micro-CT applications for the isolated human fetal heart. The search strategy identified nine eligible studies. Micro-CT is technically feasible for postmortem examination of the human fetal heart coming from early and late termination of pregnancy. It reaches high diagnostic accuracy, and it seems to perform better than autopsy in small samples or in the case of early termination of pregnancy. Applications derived from micro-CT allow multiple off-time evaluations and interdisciplinary comparisons for educational purposes and research perspectives in biological and bioengineering domains.
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