Cardiovascular Evaluation of Liver Transplant Patients by Using Coronary Calcium Scoring in ECG-Synchronized Computed Tomographic Scans

Background: The goal of cardiac evaluation of patients awaiting orthotopic liver transplantation (OLT) is to identify the patients at risk for cardiovascular events (CVEs) in the peri- and postoperative periods by opportunistic evaluation of coronary artery calcium (CAC) in non-gated abdominal computed tomographs (CT). Methods: We hypothesized that in patients with OLT, a combination of Lee's revised cardiac index (RCRI) and CAC scoring would improve diagnostic accuracy and prognostic impact compared to non-invasive cardiac testing. Therefore, we retrospectively evaluated 169 patients and compared prediction of CVEs by both methods. Results: Standard workup identified 22 patients with a high risk for CVEs during the transplant period, leading to coronary interventions. Eighteen patients had a CVE after transplant and a CAC score > 0. The combination of CAC and RCRI & GE; 2 had better negative (NPV) and positive predictive values (PPV) for CVEs (NPV 95.7%, PPV 81.6%) than standard non-invasive stress tests (NPV 92.0%, PPV 54.5%). Conclusion: The cutoff value of CAC > 0 by non-gated CTs combined with RCRI & GE; 2 is highly sensitive for identifying patients at risk for CVEs in the OLT population.

Automated summary

In patients awaiting orthotopic liver transplantation, combining Lee's revised cardiac index (RCRI) and coronary artery calcium (CAC) scoring showed better diagnostic accuracy and prognostic impact for predicting cardiovascular events compared to standard non-invasive stress tests. The cutoff value of CAC > 0 by non-gated CTs combined with RCRI & GE; 2 is highly sensitive for identifying patients at risk for cardiovascular events in this population.