Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/jcm10215032
Keywords
angiogenesis; folliculogenesis; IVF; ovarian reserve; oocyte maturation; VEGF
Categories
Funding
- Cathay General Hospital, Taipei, Taiwan [105-CGH-FJU-06, 106-CGH-FJU-07]
- Ministry of Science and Technology, Taiwan [MOST 108-2314-B-281-004]
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The study revealed a negative association between follicular fluid VEGF concentration and ovarian reserve level, as well as oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols. Additionally, a negative correlation was found between follicular fluid VEGF concentration and serum anti-Mullerian hormone (AMH) level. Oocyte maturation rate tended to increase at higher AMH levels.
Serum vascular endothelial growth factor (VEGF) is involved in follicular vascularization, oxygenation, and consequently in oocyte maturation and embryo development. Unanswered questions remain regarding the relationship of intrafollicular VEGF level in preovulatory leading follicles to oocyte maturation and ovarian reserve during ovarian stimulation. We conducted this study to investigate the relationship of intrafollicular VEGF level in the fluid of single preovulatory leading follicles to ovarian reserve and oocyte maturation in patients receiving GnRH antagonist in vitro fertilization (IVF) protocol treatment. One hundred and eighty-five patients receiving IVF treatment were recruited and assigned to low-, normal-, and high-ovarian-reserve groups according to their serum anti-Mullerian hormone (AMH) level. Follicular fluid (FF) in preovulatory leading follicles, serum profiles, and clinical variables were collected for analysis. The result disclosed a significant among-group difference in FF VEGF concentration. Moreover, the serum AMH level was also negatively correlated with FF VEGF level. The oocyte maturation rate tended to be increased at higher AMH levels. FF VEGF concentration was significantly positively correlated with basal FSH level. In conclusion, FF VEGF concentration has a negative association with ovarian reserve level and oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols.
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