4.7 Article

Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling

Related references

Note: Only part of the references are listed.
Article Rheumatology

SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade

Qianqian Liu et al.

Summary: In this study, the researchers identified SHP-2 as a novel regulator of cartilage homeostasis in osteoarthritis (OA). Inhibition of SHP-2 improved OA progression by maintaining the balance of cartilage metabolism.

ARTHRITIS & RHEUMATOLOGY (2022)

Article Pharmacology & Pharmacy

Scavenger receptor A1 attenuates aortic dissection via promoting efferocytosis in macrophages

Zhi Zhang et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade

Mingxia Zhao et al.

ACTA PHARMACEUTICA SINICA B (2019)

Article Biochemistry & Molecular Biology

Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling

Jia Yan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Cell Biology

Isolation and characterization of primary bone marrow mesenchymal stromal cells

Hongzhe Li et al.

HEMATOPOIETIC STEM CELLS IX (2016)

Review Orthopedics

Animal models of osteoarthritis: classification, update, and measurement of outcomes

Emmanuel L. Kuyinu et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2016)

Review Genetics & Heredity

SHP2 sails from physiology to pathology

Mylene Tajan et al.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2015)

Review Cell Biology

Functions of Shp2 in cancer

Jie Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

Review Endocrinology & Metabolism

The role of synovitis in osteoarthritis pathogenesis

Carla R. Scanzello et al.

Article Rheumatology

Relation of synovitis to knee pain using contrast-enhanced MRIs

K. Baker et al.

ANNALS OF THE RHEUMATIC DISEASES (2010)

Article Immunology

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

Jonathan C. Kagan et al.

NATURE IMMUNOLOGY (2008)

Review Immunology

The chemokine system in diverse forms of macrophage activation and polarization

A Mantovani et al.

TRENDS IN IMMUNOLOGY (2004)