Related references
Note: Only part of the references are listed.Therapeutic potential of natural products against atherosclerosis: Targeting on gut microbiota
Xin Zhao et al.
PHARMACOLOGICAL RESEARCH (2021)
Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture
Wei Luo et al.
CIRCULATION (2020)
Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction
Gopalkrishna Sreejit et al.
CIRCULATION (2020)
Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors
Rosaura Padilla-Salinas et al.
JOURNAL OF ORGANIC CHEMISTRY (2020)
Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists
Benjamin J. Huffman et al.
NATURE CHEMISTRY (2020)
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP
Vladislav Pokatayev et al.
NATURE IMMUNOLOGY (2020)
Beneficial bacteria activate type-I interferon production via the intracellular cytosolic sensors STING and MAVS
Jorge Gutierrez-Merino et al.
GUT MICROBES (2020)
Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure
Dan Hu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)
Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING
Yan-Ni Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress
Yan Zhang et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity
Qiang Zhang et al.
CELL RESEARCH (2020)
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
Long Shuang Huang et al.
IMMUNITY (2020)
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
Eslam Mohamed et al.
IMMUNITY (2020)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Katherine R. Balka et al.
CELL REPORTS (2020)
First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects - a cohort study
Lutz Hamann et al.
IMMUNITY & AGEING (2020)
Glucose-lowering drugs or strategies, atherosclerotic cardiovascular events, and heart failure in people with or at risk of type 2 diabetes: an updated systematic review and meta-analysis of randomised cardiovascular outcome trials
Olivia R Ghosh-Swaby et al.
Lancet Diabetes & Endocrinology (2020)
The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy
Qiyao Yang et al.
ACTA PHARMACEUTICA SINICA B (2020)
Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway
Chunyong Ding et al.
ACTA PHARMACEUTICA SINICA B (2020)
Highly pathogenic coronaviruses: thrusting vaccine development in the spotlight
Chunting He et al.
ACTA PHARMACEUTICA SINICA B (2020)
Molecular mechanisms and cellular functions of cGAS-STING signalling
Karl-Peter Hopfner et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS
Richard M. Hooy et al.
NUCLEIC ACIDS RESEARCH (2020)
Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
Yue Quan et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)
Pro-inflammatory role ofcell-freemitochondrialDNAin cardiovascular diseases
Shu Nie et al.
IUBMB LIFE (2020)
A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)
Bin Lin et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)
COVID-19 as a STING disorder with delayed over-secretion of interferon-beta
Jean-Marie Berthelot et al.
EBIOMEDICINE (2020)
Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice
Juli Bai et al.
COMMUNICATIONS BIOLOGY (2020)
Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism
Yan Gong et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes
H. Q. Hu et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)
Redox homeostasis maintained by GPX4 facilitates STING activation
Mutian Jia et al.
NATURE IMMUNOLOGY (2020)
Pharmacological management of vascular endothelial dysfunction in diabetes: TCM and western medicine compared based on biomarkers and biochemical parameters
Patrick Kwabena Oduro et al.
PHARMACOLOGICAL RESEARCH (2020)
Regulation and Consequences of cGAS Activation by Self-DNA
Christian Zierhut et al.
TRENDS IN CELL BIOLOGY (2020)
High glucose-induced ROS accumulation is a critical regulator of ERK1/2-Akt-tuberin-mTOR signalling in RGC-5 cells
Sweta Pal et al.
LIFE SCIENCES (2020)
Reactive oxygen species oxidize STING and suppress interferon production
Lili Tao et al.
ELIFE (2020)
Manipulation of immune-vascular crosstalk: new strategies towards cancer treatment
Yang Zhao et al.
ACTA PHARMACEUTICA SINICA B (2020)
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing
Carolina Uggenti et al.
NATURE GENETICS (2020)
Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?
Jean-Marie Berthelot et al.
EMERGING MICROBES & INFECTIONS (2020)
Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis
Joseph Sarhan et al.
CELL DEATH AND DIFFERENTIATION (2019)
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
Katherine C. Barnett et al.
CELL (2019)
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
Jiang Dai et al.
CELL (2019)
STING palmitoylation as a therapeutic target
Anne Louise Hansen et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2019)
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
Jianjun Wu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Xiang Gui et al.
NATURE (2019)
Structural basis of STING binding with and phosphorylation by TBK1
Conggang Zhang et al.
NATURE (2019)
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor
Douglas W. Thomson et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus (vol 26, pg 2377, 2019)
Matteo Gentili et al.
CELL REPORTS (2019)
STING-mediated intestinal barrier dysfunction contributes to lethal sepsis
Qiongyuan Hu et al.
EBIOMEDICINE (2019)
The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
Juli Bai et al.
DIABETES (2019)
Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease
Marc Y. Donath et al.
ENDOCRINE REVIEWS (2019)
Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models
Mona Motwani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
Wei Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Identification of a mesenchymal progenitor cell hierarchy in adipose tissue
David Merrick et al.
SCIENCE (2019)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Carina C. de Oliveira Mann et al.
CELL REPORTS (2019)
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
Christian Zierhut et al.
CELL (2019)
STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
Sabrina L. Ergun et al.
CELL (2019)
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Lodoe Lama et al.
NATURE COMMUNICATIONS (2019)
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3
Ning Li et al.
REDOX BIOLOGY (2019)
Stimulator of interferon genes agonists attenuate type I diabetes progression in NOD mice
Henrique Lemos et al.
IMMUNOLOGY (2019)
PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response
Tian Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor
Koji Ozasa et al.
FRONTIERS IN IMMUNOLOGY (2019)
Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven protumorigenic senescent secretion
Huanmin Niu et al.
ACTA PHARMACEUTICA SINICA B (2019)
Transcriptional regulation of human cyclic GMP-AMP synthase gene
Hai-Yan Chen et al.
CELLULAR SIGNALLING (2019)
The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Jae Ho Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance
Larysa Yuzefovych et al.
PLOS ONE (2019)
TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
Ricardo J. Antonia et al.
SCIENTIFIC REPORTS (2019)
Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats
Ellis N. ter Horst et al.
BASIC RESEARCH IN CARDIOLOGY (2019)
Programmed Necrosis and Disease: We interrupt your regular programming to bring you necroinflammation
Eui Ho Kim et al.
CELL DEATH AND DIFFERENTIATION (2019)
The Multifunctional Protein p62 and its Mechanistic Roles in Cancers
Shunbin Ning et al.
CURRENT CANCER DRUG TARGETS (2019)
Cardiovascular mortality attributable to dietary risk factors in 51 countries in the WHO European Region from 1990 to 2016: a systematic analysis of the Global Burden of Disease Study
Toni Meier et al.
EUROPEAN JOURNAL OF EPIDEMIOLOGY (2019)
STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases
Lutz Hamann et al.
GERONTOLOGY (2019)
STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
Yongsheng Yu et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
Sonal Srikanth et al.
NATURE IMMUNOLOGY (2019)
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
Tony Siu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
Jeonghan Kim et al.
SCIENCE (2019)
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
Yuk Yuen Lan et al.
AGING CELL (2019)
Type I Interferons and Cancer: An Evolving Story Demanding Novel Clinical Applications
Eleonora Arico et al.
CANCERS (2019)
Tight nuclear tethering of cGAS is essential for preventing autoreactivity
Hannah E. Volkman et al.
ELIFE (2019)
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
Salla Keskitalo et al.
FRONTIERS IN IMMUNOLOGY (2019)
Regulating IRFs in IFN Driven Disease
Caroline A. Jefferies
FRONTIERS IN IMMUNOLOGY (2019)
Effects of stress on the development and progression of cardiovascular disease
Mika Kivimaki et al.
NATURE REVIEWS CARDIOLOGY (2018)
cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING
Zhao Lei et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue
Peng Zhao et al.
CELL (2018)
Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury
Dian J. Cao et al.
CIRCULATION (2018)
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
Thaneas Prabakaran et al.
EMBO JOURNAL (2018)
Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels
Modi Wang et al.
FUTURE MEDICINAL CHEMISTRY (2018)
Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation
Chun-Seok Cho et al.
HEPATOLOGY (2018)
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Gina A. Montealegre Sanchez et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease
J. T. Qiao et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2018)
A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing
Pei-Hui Wang et al.
NUCLEIC ACIDS RESEARCH (2018)
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Kate McArthur et al.
SCIENCE (2018)
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
Mingjian Du et al.
SCIENCE (2018)
A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy
Rohit G. Saldanha et al.
FRONTIERS IN IMMUNOLOGY (2018)
Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit
Nathan Meade et al.
CELL (2018)
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
Gillian Dunphy et al.
MOLECULAR CELL (2018)
Parkin and PINK1 mitigate STING-induced inflammation
Danielle A. Sliter et al.
NATURE (2018)
Targeting STING with covalent small-molecule inhibitors
Simone M. Haag et al.
NATURE (2018)
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
Anne Louise Hansen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice
Xianjun Luo et al.
GASTROENTEROLOGY (2018)
Diagnosis and Management of Nonalcoholic Fatty Liver Disease
Sonali Paul et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)
STING Signaling Promotes Apoptosis, Necrosis, and Cell Death: An Overview and Update
Song Liu et al.
MEDIATORS OF INFLAMMATION (2018)
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
Haipeng Liu et al.
NATURE (2018)
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
Senlin Li et al.
CELL REPORTS (2018)
Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
Folkert Steinhagen et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2018)
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses
William O. Hahn et al.
JCI INSIGHT (2018)
Small-Molecule Targets in Tumor Immunotherapy
Hui-Fang Zhu et al.
NATURAL PRODUCTS AND BIOPROSPECTING (2018)
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection
Yutao Wang et al.
IMMUNITY (2017)
Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling
Isabelle Melki et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)
Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism
Liangshuai Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
STING-associated vasculopathy develops independently of IRF3 in mice
James D. Warner et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
cGAS surveillance of micronuclei links genome instability to innate immunity
Karen J. Mackenzie et al.
NATURE (2017)
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou et al.
NATURE (2017)
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders
Liudmila Andreeva et al.
NATURE (2017)
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Kevin R. King et al.
NATURE MEDICINE (2017)
Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases
Yaxing Zhang et al.
PHYSIOLOGY (2017)
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
Juli Bai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
Maroof Hasan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
cGAS is essential for cellular senescence
Hui Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review
Anne-Claire Desbois et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2017)
Signalling strength determines proapoptotic functions of STING
Muhammet F. Gulen et al.
NATURE COMMUNICATIONS (2017)
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
Jessica Vincent et al.
NATURE COMMUNICATIONS (2017)
Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and CanBe Targeted to Enhance Anti-tumor Response
Vijay K. Gonugunta et al.
CELL REPORTS (2017)
The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response
Qiang Wang et al.
PLOS PATHOGENS (2017)
The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
Julia M. Weiss et al.
ONCOIMMUNOLOGY (2017)
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Justin Hall et al.
PLOS ONE (2017)
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt et al.
CELL (2017)
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum
Julien Moretti et al.
CELL (2017)
cGAS is activated by DNA in a length-dependent manner
Stefanie Luecke et al.
EMBO REPORTS (2017)
Inhibition of IKK 3 and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes
Elif A. Oral et al.
CELL METABOLISM (2017)
Autophagy and Mitophagy in Cardiovascular Disease
Jose Manuel Bravo-San Pedro et al.
CIRCULATION RESEARCH (2017)
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity
Yun Mao et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)
DNA Damage and Repair in Vascular Disease
Anna Uryga et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 78 (2016)
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
Chih-Hang Anthony Tang et al.
CANCER RESEARCH (2016)
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
Martin K. Thomsen et al.
HEPATOLOGY (2016)
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Axel Roers et al.
IMMUNITY (2016)
Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes
Arvin Iracheta-Vellve et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
IRF3 promotes adipose inflammation and insulin resistance and represses browning
Manju Kumari et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Gregory Thomas Brown et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2016)
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
Wei-Wei Luo et al.
NATURE IMMUNOLOGY (2016)
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
Qi Chen et al.
NATURE IMMUNOLOGY (2016)
Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins
Baoyu Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
Benjamin Richter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Activation of STING requires palmitoylation at the Golgi
Kojiro Mukai et al.
NATURE COMMUNICATIONS (2016)
Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
Warrison A. Andrade et al.
CELL REPORTS (2016)
The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases
Kiichi Nakahira et al.
ANTIOXIDANTS & REDOX SIGNALING (2015)
The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases
Xiao-Jing Zhang et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes
Meghan Delmastro-Greenwood et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase-DNA Interaction
Jie An et al.
JOURNAL OF IMMUNOLOGY (2015)
Mitochondrial DNA stress primes the antiviral innate immune response
A. Phillip West et al.
NATURE (2015)
Mast cells in human and experimental cardiometabolic diseases
Guo-Ping Shi et al.
NATURE REVIEWS CARDIOLOGY (2015)
Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses
Zhe Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Siqi Liu et al.
SCIENCE (2015)
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation
Jiayi Yu et al.
NATURE COMMUNICATIONS (2015)
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
Gil Ju Seo et al.
CELL REPORTS (2015)
PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
Zexing Li et al.
PLOS PATHOGENS (2015)
Stimulator of Interferon Genes-Associated Vasculopathy With Onset in Infancy A Mimic of Childhood Granulomatosis With Polyangiitis
Justine Munoz et al.
JAMA DERMATOLOGY (2015)
Macrophage subsets in atherosclerosis
Giulia Chinetti-Gbaguidi et al.
NATURE REVIEWS CARDIOLOGY (2015)
Autophagy side of MB21D1/cGAS DNA sensor
Qiming Liang et al.
AUTOPHAGY (2014)
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White et al.
CELL (2014)
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux et al.
CELL (2014)
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
Qiming Liang et al.
CELL HOST & MICROBE (2014)
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
Kathrine Hansen et al.
EMBO JOURNAL (2014)
Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin
Ding-Sheng Jiang et al.
HYPERTENSION (2014)
Selective TBK1/IKKi dual inhibitors with anticancer potency
Jijia Li et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
Nadia Jeremiah et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
An Alternative Splicing Isoform of MITA Antagonizes MITA-Mediated Induction of Type I IFNs
Honghe Chen et al.
JOURNAL OF IMMUNOLOGY (2014)
TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner
Andrea Ablasser et al.
JOURNAL OF IMMUNOLOGY (2014)
Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1
Takayuki Abe et al.
JOURNAL OF VIROLOGY (2014)
Mitigating the toxic effects of anticancer immunotherapy
Tara C. Gangadhar et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2014)
Activated STING in a Vascular and Pulmonary Syndrome
Y. Liu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Microbial composition of atherosclerotic plaques
C. A. Calandrini et al.
ORAL DISEASES (2014)
STING-dependent cytosolic DNA sensing pathways
Glen N. Barber
TRENDS IN IMMUNOLOGY (2014)
Regulation of type I interferon responses
Lionel B. Ivashkiv et al.
NATURE REVIEWS IMMUNOLOGY (2014)
Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance
Xin-An Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy
Jing Lu et al.
BASIC RESEARCH IN CARDIOLOGY (2013)
Cyclic [G(2′,5′) pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
Pu Gao et al.
CELL (2013)
Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
Hiroyasu Konno et al.
CELL (2013)
Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization
Jun Eguchi et al.
DIABETES (2013)
Species-specific detection of the antiviral small-molecule compound CMA by STING
Taner Cavlar et al.
EMBO JOURNAL (2013)
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
Xin Li et al.
IMMUNITY (2013)
Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study
Gillian I. Rice et al.
LANCET NEUROLOGY (2013)
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Andrea Ablasser et al.
NATURE (2013)
Structural mechanism of cytosolic DNA sensing by cGAS
Filiz Civril et al.
NATURE (2013)
An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
Shannon M. Reilly et al.
NATURE MEDICINE (2013)
Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
Guanghui Yi et al.
PLOS ONE (2013)
STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
Jan Petrasek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Jiaxi Wu et al.
SCIENCE (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition
Jin Koo Kim et al.
NEOPLASIA (2013)
Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
Songying Ouyang et al.
IMMUNITY (2012)
Endoplasmic Reticulum Stress Regulates the Innate Immunity Critical Transcription Factor IRF3
Yi-Ping Liu et al.
JOURNAL OF IMMUNOLOGY (2012)
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
Qian Yin et al.
MOLECULAR CELL (2012)
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
Chang Shu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
Yasuo Tanaka et al.
SCIENCE SIGNALING (2012)
Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice
Chie Hayashi et al.
ATHEROSCLEROSIS (2011)
ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells
Fanlei Hu et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
Identification and characterization of a loss-of-function human MPYS variant
L. Jin et al.
GENES AND IMMUNITY (2011)
STING is a direct innate immune sensor of cyclic di-GMP
Dara L. Burdette et al.
NATURE (2011)
Human oral, gut, and plaque microbiota in patients with atherosclerosis
Omry Koren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure
Heiko Bugger et al.
CARDIOVASCULAR RESEARCH (2010)
DsbA-L Alleviates Endoplasmic Reticulum Stress-Induced Adiponectin Downregulation
Lijun Zhou et al.
DIABETES (2010)
Blocking Interferon β Stimulates Vascular Smooth Muscle Cell Proliferation and Arteriogenesis
Stephan H. Schirmer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs
Michael R. Denny et al.
JOURNAL OF IMMUNOLOGY (2010)
c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
Joshua J. Woodward et al.
SCIENCE (2010)
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
Wenxiang Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Interferon-β signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
Stephan H. Schirmer et al.
CIRCULATION RESEARCH (2008)
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Bo Zhong et al.
IMMUNITY (2008)
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Hiroki Ishikawa et al.
NATURE (2008)
Reversible cardiomyopathy caused by administration of interferon alpha
AY Khakoo et al.
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2005)
Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis
M Morita et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
IKKε and TBK1 are essential components of the IRF3 signaling pathway
KA Fitzgerald et al.
NATURE IMMUNOLOGY (2003)
Share Paper
