Journal
SCIENCE ADVANCES
Volume 7, Issue 50, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abj1083
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Funding
- Basic Science Research Program, the Ministry of Science and ICT (MSIT) [2020R1A2B5B03002344]
- Bio & Medical Technology Development Program, the Ministry of Science and ICT (MSIT) [2018M3A9E2024579]
- Korea Health Technology R&D Project, the Ministry of Health Welfare [HI18C0089]
- Korea Medical Device Development Fund grant, the Korean government (the Ministry of Science and ICT) [202011A05-05]
- Korea Medical Device Development Fund grant, the Korean government (Ministry of Trade, Industry and Energy) [202011A05-05]
- Korea Medical Device Development Fund grant, the Korean government (Ministry of Health & Welfare, Republic of Korea) [202011A05-05]
- Korea Medical Device Development Fund grant, the Korean government (Ministry of Food and Drug Safety) [202011A05-05]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI
- the Ministry of Health & Welfare, Republic of Korea) [HR16C0002]
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In this study, a PLGA scaffold combined with magnesium hydroxide and bone extracellular matrix was utilized to enhance anti-inflammation, mechanical properties, and osteoconductivity. Additionally, the development of a bioactive nanocomplex containing polydeoxyribonucleotide and bone morphogenetic protein 2 showed synergistic abilities in angiogenesis and bone regeneration, leading to outstanding performance in anti-inflammation, angiogenesis, and osteogenesis for the PME/NC scaffold. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration.
Biodegradable polymers have been used with various systems for tissue engineering. Among them, poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for bone regeneration because of its great biocompatibility and biodegradability properties. However, there remain substantial cruxes that the by-products of PLGA result in an acidic environment at the implanting site, and the polymer has a weak mechanical property. In our previous study, magnesium hydroxide (MH) and bone extracellular matrix are combined with a PLGA scaffold (PME) to improve anti-inflammation and mechanical properties and osteoconductivity. In the present study, the development of a bioactive nanocomplex (NC) formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provides synergistic abilities in angiogenesis and bone regeneration. This PME hybrid scaffold immobilized with NC (PME/NC) achieves outstanding performance in anti-inflammation, angiogenesis, and osteogenesis. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration.
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