Metformin-A Thought-provoking Addition to Anticancer Therapies Reply

Summary: This study aimed to investigate whether the addition of metformin to chemoradiotherapy could improve outcomes in patients with unresected locally advanced non-small cell lung cancer. However, the results showed that the addition of metformin was associated with worse treatment efficacy and increased toxic effects compared with combined modality therapy alone, indicating that metformin is not recommended in this patient population.