A Sustainable Iodine Catalyzed C(sp3)-H Bond Functionalization of Benzylamines towards Synthesis of Bis(indolyl)methanes and Tris(indolyl)methanes

A simple process of arylmethylamines C(sp(3))-H bond functionalization under aerobic condition has been developed for 3,3'-bis(indolyl)methanes (BIMs) and tris(indolyl)methanes synthesis in presence of various substituted indoles. The present transformation accounts BIMs in excellent yields up to 94 %viaC-C and C-N bond formation in short reaction time represents fine alternative route. The catalytic performance of iodine shows good tolerance towards different functional groups, and has great utility in exploring substrate scope.

Automated summary

A simple process for arylmethylamines C(sp(3))-H bond functionalization under aerobic conditions has been developed, resulting in successful synthesis of 3,3'-bis(indolyl)methanes (BIMs) and tris(indolyl)methanes with yields up to 94%. The use of iodine as a catalyst shows good tolerance towards different functional groups and has great potential in exploring substrate scope.