Journal
CHEMISTRYSELECT
Volume 6, Issue 43, Pages 12220-12223Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103481
Keywords
Carbonylation; Heterocycle synthesis; Palladium catalyst; Propargyl amine; Pyrrolones
Categories
Funding
- Joint Funds of the Zhejiang Provincial Natural Science Foundation of China [LTY21B020001]
- Fundamental Research Funds of Zhejiang Sci-Tech University [2021Q052]
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A new method has been developed for the construction of 1,5-dihydro-2H-pyrrol-2-one scaffolds through palladium-catalyzed carbonylative cyclization of propargyl amines and acid chlorides. The reaction provides a facile approach to access various 1-acyl-1,5-dihydro-2H-pyrrol-2-ones in high yields.
A palladium-catalyzed carbonylative cyclization of propargyl amines and acid chlorides has been developed for the construction of 1,5-dihydro-2H-pyrrol-2-one scaffolds. By employing TFBen as the CO source, the reaction provides a facile approach to access various 1-acyl-1,5-dihydro-2H-pyrrol-2-ones in high yields.
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