Journal
CHEMISTRYSELECT
Volume 6, Issue 45, Pages 12757-12795Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103779
Keywords
Biological Activities; Chalcones; Hydrazines; Pharmaceutical Activities; and Pyrazolines
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Chalcones are a group of aromatic ketones with enone moiety that exhibit a wide range of biological activities, and when synthesized into pyrazolines, their biological activity can be enhanced. This study reviews the chemistry of various chalcone-based pyrazolines and their derivatives up to 2021.
Chalcones are alpha, beta unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antimalarial. Nitrogen-containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N- heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone-based pyrazolines and their derivatives with the available data till 2021.
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