4.4 Article

Fe(III)-Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspects

Journal

CHEMISTRYSELECT
Volume 7, Issue 1, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103880

Keywords

aluminium substitution; ion exchange; layered materials; intercalation compounds; pyroaurite-like compounds

Funding

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/15900-0, 2016/13862-9, 2012/12209-9]
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 305446/2017-7]
  3. Research Academic Cooperation Agreement PRC-CNRS-FAPESP (PRC-Projets) [1688]
  4. Research Academic Cooperation Agreement PRC-CNRS-FAPESP (SPRINT-Sao Paulo Researchers in International Collaboration) [2016/50317-9]

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This study investigates the application of Fe-III-LDH as drug carriers by gradually replacing Al cation with Fe-III. The study shows that topotactic ion exchange is a potential approach for the intercalation of non-steroidal anti-inflammatory drugs into Fe-III-LDH.
In this work, Al cation was gradually replaced by Fe-III in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of Fe-III into LDH layers, as well the intercalation of organic anions in the iron-based materials, is challenging. Several studies approach the intercalation of non-steroidal anti-inflammatory drugs such as anionic naproxen (NAP) into Al-LDH. Thus, NAP was applied here as a model drug for the study of compositional and structural aspects of novel Fe-III-LDH carriers envisaging to shed light on the intercalation of other carboxylate drugs into these materials. LDH of general [M2FeyAl(1-y)(OH)(6)]A(n-) compositions (M-II=Mg or Zn; A(n-)=anion of charge n) were investigated using two synthetic methods for NAP intercalation. Full X-ray diffraction profile refinement and a crystal-geometrical reasoning were used to strengthen the results interpretation. Unlike coprecipitation, in which probably NAP complexation with Fe-III hinders LDH-NAP self-assembling, topotactic ion exchange demonstrated to be a potential approach.

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