4.4 Article

α-Tocopherol-Conjugated, Open Chain Sugar-Mimicking Cationic Lipids: Design, Synthesis and In-Vitro Gene Transfection Properties

Related references

Note: Only part of the references are listed.
Article Materials Science, Biomaterials

Arginine-tocopherol bioconjugated lipid vesicles for selective pTRAIL delivery and subsequent apoptosis induction in glioblastoma cells

Venkatesh Ravula et al.

Summary: Incorporating therapeutic genes into glioblastoma using AT nanovesicles has shown successful delivery of pTRAIL gene with high transfection efficiency. The AT-based/pTRAIL system presents a potentially safe and efficient therapeutic strategy for glioblastoma gene therapy.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Chemistry, Organic

α-Tocopherol-anchored gemini lipids with delocalizable cationic head groups: the effect of spacer length on DNA compaction and transfection properties

Mallikarjun Gosangi et al.

Summary: Understanding the role of spacer length in gemini lipids is crucial for designing efficient gene delivery vehicles. Lipids with a 6 methylene spacer show optimal DNA compaction ability and transfection efficiency. Overall, gemini lipids with a six methylene aliphatic spacer have the maximum potential to deliver genes.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Dramatic influence of the hydroxy functionality of azasugar moiety in the head group region of tocopherol-based cationic lipids on in vitro gene transfection efficacies

Venkanna Muripiti et al.

Summary: The study designed and synthesized two cationic lipids, Toc-Aza with aza sugar head group and Toc-Pyr as control lipid. In vitro transfection studies showed that Toc-Aza exhibited significantly higher transfection efficacy compared to Toc-Pyr in HEK-293, CHO, and HepG2 cell lines.

NEW JOURNAL OF CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

Zhong-Jian Chen et al.

NANO LETTERS (2020)

Review Chemistry, Multidisciplinary

Review of Zinc(II) Scaffolds: Efficient Role in Gene Delivery

Venkanna Muripiti et al.

CHEMISTRYSELECT (2020)

Article Chemistry, Physical

Sustainable technologies for liposome preparation

Maja Leitgeb et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2020)

Article Biochemistry & Molecular Biology

Tumor Chemosensitization through Oncogene Knockdown Mediated by Unique α-Tocopherylated Cationic Geminis

Mohini Kamra et al.

BIOMACROMOLECULES (2019)

Review Engineering, Biomedical

Sugar alcohol-based polymeric gene carriers: Synthesis, properties and gene therapy applications

Seo Jin Hong et al.

ACTA BIOMATERIALIA (2019)

Article Pharmacology & Pharmacy

Structure-activity relationship of serotonin derived tocopherol lipids

Venkanna Muripiti et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Chemistry, Applied

Sugar-based gene delivery systems: Current knowledge and new perspectives

Seo Jin Hong et al.

CARBOHYDRATE POLYMERS (2018)

Article Medicine, Research & Experimental

Optimization of a cationic liposome-based gene delivery system for the application of miR-145 in anticancer therapeutics

Jin Tao et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Chemistry, Organic

Design, synthesis and in vitro evaluation of D-glucose-based cationic glycolipids for gene delivery

Chengxi He et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

Review Materials Science, Biomaterials

Utilising inorganic nanocarriers for gene delivery

Xian Jun Loh et al.

BIOMATERIALS SCIENCE (2016)

Review Chemistry, Multidisciplinary

Bioapplications of hyperbranched polymers

Dali Wang et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Multidisciplinary Sciences

Lysosomal Trafficking of TGFBIp via Caveolae-Mediated Endocytosis

Seung-Il Choi et al.

PLOS ONE (2015)

Review Biochemistry & Molecular Biology

Novel methods for liposome preparation

Yogita P. Patil et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2014)

Review Genetics & Heredity

Non-viral vectors for gene-based therapy

Hao Yin et al.

NATURE REVIEWS GENETICS (2014)

Review Biochemical Research Methods

The Headgroup Evolution of Cationic Lipids for Gene Delivery

Defu Zhi et al.

BIOCONJUGATE CHEMISTRY (2013)

Review Chemistry, Multidisciplinary

Liposomes for intravitreal drug delivery: A state of the art

Amelie Bochot et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Medicine, Research & Experimental

Synthesis and Gene Transfer Activities of Novel Serum Compatible Reducible Tocopherol-Based Cationic Lipids

Bhavani Kedika et al.

MOLECULAR PHARMACEUTICS (2012)

Article Engineering, Biomedical

Accelerated gene transfer through a polysorbitol-based transporter mechanism

Mohammad Ariful Islam et al.

BIOMATERIALS (2011)

Article Biotechnology & Applied Microbiology

Chitosan as a condensing agent induces high gene transfection efficiency and low cytotoxicity of liposome

Ruizhen Liu et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2011)

Article Chemistry, Multidisciplinary

Dramatic influence of the orientation of linker between hydrophilic and hydrophobic lipid moiety in liposomal gene delivery

Mukthavararn Rajesh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Pharmacology & Pharmacy

Multivariate toxicity screening of liposomal formulations on a human buccal cell line

Gro Smistad et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

Review Chemistry, Medicinal

Cationic Liposomes as non-viral carriers of gene medicines: Resolved issues, open questions, and future promises

Priya Prakasb Karmali et al.

MEDICINAL RESEARCH REVIEWS (2007)

Review Biotechnology & Applied Microbiology

Design and development of polymers for gene delivery

DW Pack et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Chemistry, Medicinal

Design, synthesis, and transfection biology of novel cationic glycolipids for use in liposomal gene delivery

R Banerjee et al.

JOURNAL OF MEDICINAL CHEMISTRY (2001)

Review Biochemistry & Molecular Biology

Nonviral gene therapy: promises and challenges

S Li et al.

GENE THERAPY (2000)