Journal
CHEMISTRYSELECT
Volume 7, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202104032
Keywords
1; 4-Dihydropyridines; Green Chemistry; Hantzsch reaction; Microwave Irradiation
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This review summarizes recent advances in the synthesis and aromatization of Hantzsch 1,4-dihydropyridines under microwave irradiation, highlighting the use of this green approach.
Hantzsch reaction, leading to the synthesis of 1,4-dihydropyridines (1,4-DHPs) with momentous biological activities and pharmacological properties is a well-known MCR. In recent years, microwave irradiation (MWI) has been successfully used as the unconventional and green source of energy to promote organic transformations including Hantzsch 1,4-dihydropyridines. Literature survey disclosed that construction of 1,4-DHPs as well as their aromatization can be successfully performed under MWI in solution as well as in dry media. In this review, we try to underscore recent advances in the synthesis and aromatization of Hantzsch 1,4-DHPs under MWI as green approach.
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