Liposomal Encapsulation of Phenolic Compounds for Augmentation of Bio-Efficacy: A Review

Naturally occurring phenolic compounds (PCs) exhibit potential biological efficiencies and have potential applications in the food and pharmaceutical industries. Poor water solubility along with some other factors limits the usage of PCs in different industrial sectors. The bio-efficacy of PCs is also affected due to their low water solubilities. Suitable encapsulating systems are thus required to maximize the water solubility and hence enhance the efficacies of bioactive PCs. Liposomal encapsulation is a good option as reflected in numerous research works. In this review, we have discussed different conventional methods and modified methods utilized to prepare PC-loaded liposomes and the ensuing effect of encapsulation on the stability and bio-efficacies of PCs. The encapsulation efficiencies of different methods have also been discussed. A comparative assessment of different methods applied for liposomal encapsulation of PCs and their effectiveness in enhancing bio-efficacy is the key feature of this review.

Automated summary

This article discusses the potential applications of phenolic compounds in the food and pharmaceutical industries, as well as the limitations they face due to poor water solubility. The focus is on analyzing the effect of liposomal encapsulation on improving the water solubility and bioefficacy of phenolic compounds.