Pyrrolidine Derivatives as Anti-diabetic Agents: Current Status and Future Prospects

Diabetes Mellitus (DM) is one of the leading causes of deaths worldwide and is becoming an epidemic in many countries. Sedentary lifestyles, less physical activity, environmental and genetic changes are some of the factors which are responsible for the disease. It is putting a lot of economic burden especially on developing and under developed countries. Hence there is a dire need for the management of this disease. The use of current available therapies is associated with one or more side effects or financial burden. From the past few years, pyrrolidine derivatives have grabbed much of the attention of the researchers for the development of the novel molecules that can be used as a drug candidate for the treatment of Diabetes Mellitus. The current review attempts and aims at compiling the important work done in this relevant area which will help the researchers to design and synthesize the novel Pyrrolidine derivatives as antidiabetic agents with desired clinical outputs.

Automated summary

Diabetes Mellitus is a leading cause of deaths worldwide and is particularly burdensome on developing and underdeveloped countries. The use of pyrrolidine derivatives as drug candidates for diabetes treatment is gaining attention, and this review aims to compile important research in this area to aid researchers in designing and synthesizing novel pyrrolidine derivatives with desired clinical outcomes.