Journal
FOOD BIOSCIENCE
Volume 43, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fbio.2021.101298
Keywords
Tiredness; Hydrolysis; Fermentation; Energy metabolism
Categories
Funding
- National Natural Science Foundation of China [8170306]
- Research Fund for Taiwan-Straits Postdoctoral Exchange Program [2018B003]
- Special Funds for Science and Technology innovation of Fujian Agriculture and Forestry University [CXZX2018063]
- Fujian Science and Technology Economic Integration Service Platform of Fujian Association for Science and Technology [2020K02]
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With the development of modern society, exercise-induced fatigue has become a widespread problem, leading to increasing research attention on anti-fatigue peptides. Numerous natural bioactive peptides have been identified with the ability to prevent and alleviate exercise-induced fatigue.
Exercise-induced fatigue is charactered by the feeling of tiredness and a decrease in muscle performance resulting from intense and prolonged exercise. With the development of modern society, exercise-induced fatigue has become a widespread problem besetting people's daily life. Over the years, increasing attention has been paid to the study of anti-fatigue peptides. Several animal models have been developed to mimic exercise-induced fatigue, which could be employed to measure the activities of anti-fatigue peptides isolated from a wide range of sources. A number of natural bioactive peptides were identified with ability to prevent and alleviate exercise-induced fatigue via various complex biological reactions, with possible molecular mechanisms being also explored extensively. In this review, we summarize the major research findings on anti-fatigue peptides, including the isolation and preparation of anti-fatigue peptides, the widely adopted methods for evaluation of anti-fatigue activities, and possible anti-fatigue mechanisms. Current evidence strongly supports that anti-fatigue peptides may relieve exercise-induced fatigue via multiple mechanisms, including participation and regulation of energy metabolism; inhibition of inflammatory responses; reduction of reactive oxygen species content; and regulation of neurotransmitters, etc. In conclusion, the review provides key research perspectives to inform further research on anti-fatigue peptides for the food industry.
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