Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis

A numerical simulation of a pulsed floating electrode dielectric barrier discharge (FE-DBD) at atmospheric pressure, used for melanoma cancer cell therapy, is performed using a plasma model in COMSOL Multiphysics software. Distributions of electron density, space charge, and electric field are presented at different instants of the pulsed argon discharge. Significant results related to the characteristics of the plasma device used, the inter-electrodes distance, and the power supply are obtained to improve the efficiency of FE-DBD apparatus for melanoma cancer cell treatment. The FE-DBD presents a higher sensitivity to short pulse durations, related to the accumulated charge over the dielectric barrier around the powered electrode. At higher applied voltage, more energy is injected into the discharge channel and an increase in electron density and electric consumed power is noted. Anticancer activity provided by the FE-DBD plasma is improved using a small interelectrode distance with a high electron emission coefficient and a high dielectric constant with a small dielectric thickness, allowing higher electron density, generating reactive species responsible for the apoptosis of tumor cells.

Automated summary

The numerical simulation of FE-DBD for melanoma cancer cell therapy shows the importance of optimizing plasma device characteristics, inter-electrode distance, and power supply for efficiency improvement. The sensitivity of FE-DBD to short pulse durations and the increase in energy injection with higher applied voltage are key factors in enhancing treatment efficacy.